Original Article
Is there a Publication Bias in Behavioural Intranasal Oxytocin Research on Humans? Opening the File Drawer of One Laboratory
Abstract
The neurohormone oxytocin (OT) has been one the most studied peptides in behavioural sciences over the past two decades. Primarily known for its crucial role in labour and lactation, a rapidly growing literature suggests that intranasal OT (IN‐OT) may also play a role in the emotional and social lives of humans. However, the lack of a convincing theoretical framework explaining the effects of IN‐OT that would also allow the prediction of which moderators exert their effects and when has raised healthy skepticism regarding the robustness of human behavioural IN‐OT research. Poor knowledge of the exact pharmacokinetic properties of OT, as well as crucial statistical and methodological issues and the absence of direct replication efforts, may have lead to a publication bias in the IN‐OT literature, with many unpublished studies with null results remaining buried in laboratory drawers. Is there a file drawer problem in IN‐OT research? If this is the case, it may also be true in our own laboratory. The present study aims to answer this question, document the extent of the problem and discuss its implications for OT research. For eight studies (including 13 dependent variables overall, as assessed through 25 different paradigms) performed in our laboratory between 2009 and 2014 on 453 subjects, the results obtained were too often not those that were expected. Only five publications emerged from our studies and only one of these reported a null finding. After realising that our publication portfolio has become less and less representative of our actual findings and because the nonpublication of our data might contribute to generating a publication bias in IN‐OT research, we decided to retrieve these studies from our drawer and encourage other laboratories to do the same.
Citing Literature
Number of times cited: 29
- Sarah A. Grainger, Julie D. Henry, Henriette R. Steinvik, Eric J. Vanman, Peter G. Rendell and Izelle Labuschagne, Intranasal oxytocin does not reduce age-related difficulties in social cognition, Hormones and Behavior, 99, (25), (2018).
- Saren H. Seeley, Ying-hui Chou and Mary-Frances O’Connor, Intranasal oxytocin and OXTR genotype effects on resting state functional connectivity: A systematic review, Neuroscience & Biobehavioral Reviews, 10.1016/j.neubiorev.2018.09.011, 95, (17-32), (2018).
- Sébastien Tremblay, K.M. Sharika and Michael L. Platt, Social Decision-Making and the Brain: A Comparative Perspective, Trends in Cognitive Sciences, 21, 4, (265), (2017).
- Lina Koppel, David Andersson, India Morrison, Daniel Västfjäll and Gustav Tinghög, The (Null) Effect of Affective Touch on Betrayal Aversion, Altruism, and Risk Taking, Frontiers in Behavioral Neuroscience, 11, (2017).
- Auriane Duchemin, Adele M.H. Seelke, Trenton C. Simmons, Sara M. Freeman and Karen L. Bales, Localization of oxytocin receptors in the prairie vole ( Microtus ochrogaster ) neocortex, Neuroscience, 10.1016/j.neuroscience.2017.02.017, 348, (201-211), (2017).
- Ellen R. Bradley and Joshua D. Woolley, Oxytocin effects in schizophrenia: Reconciling mixed findings and moving forward, Neuroscience & Biobehavioral Reviews, 10.1016/j.neubiorev.2017.05.007, 80, (36-56), (2017).
- Lincoln M. Tracy, Izelle Labuschagne, Nellie Georgiou-Karistianis, Stephen J. Gibson and Melita J. Giummarra, Sex-specific effects of intranasal oxytocin on thermal pain perception: A randomised, double-blind, placebo-controlled cross-over study, Psychoneuroendocrinology, 83, (101), (2017).
- Maartje S. Spetter and Manfred Hallschmid, Current findings on the role of oxytocin in the regulation of food intake, Physiology & Behavior, 10.1016/j.physbeh.2017.03.007, 176, (31-39), (2017).
- Donald R. Williams and Paul-Christian Bürkner, Effects of intranasal oxytocin on symptoms of schizophrenia: A multivariate Bayesian meta-analysis, Psychoneuroendocrinology, 10.1016/j.psyneuen.2016.10.013, 75, (141-151), (2017).
- Narun Pornpattananangkul, Junfeng Zhang, Qiaoyu Chen, Bing Cai Kok and Rongjun Yu, Generous to whom? The influence of oxytocin on social discounting, Psychoneuroendocrinology, 79, (93), (2017).
- Luigi Macchitella, Tommaso Stegagno, Roberto Giaconella, Eugenia Polizzi di Sorrentino, Gabriele Schino and Elsa Addessi, Oxytocin improves the ability of dogs to follow informative pointing: a neuroemotional hypothesis, Rendiconti Lincei, 28, 1, (105), (2017).
- Peter B. Gray, Timothy S. McHale and Justin M. Carré, A review of human male field studies of hormones and behavioral reproductive effort, Hormones and Behavior, 91, (52), (2017).
- Sarah K. Williams Avram and Adi Cymerblit-Sabba, Vasopressin: Roles in Modulating Social Behaviors, Hormones, Brain and Behavior, 10.1016/B978-0-12-803592-4.00057-2, (279-304), (2017).
- Carlos Cueva, R Edward Roberts, Tom J Spencer, Nisha Rani, Michelle Tempest, Philippe N Tobler, Joe Herbert and Aldo Rustichini, Testosterone administration does not affect men's rejections of low ultimatum game offers or aggressive mood, Hormones and Behavior, 87, (1), (2017).
- Bruno Lambert, Carolyn H. Declerck, Christophe Boone and Paul M. Parizel, A functional MRI study on how oxytocin affects decision making in social dilemmas: Cooperate as long as it pays off, aggress only when you think you can win, Hormones and Behavior, 10.1016/j.yhbeh.2017.06.011, 94, (145-152), (2017).
- Mathias Valstad, Gail A. Alvares, Maiken Egknud, Anna Maria Matziorinis, Ole A. Andreassen, Lars T. Westlye and Daniel S. Quintana, The correlation between central and peripheral oxytocin concentrations: A systematic review and meta-analysis, Neuroscience & Biobehavioral Reviews, 78, (117), (2017).
- Nicholas M. Grebe, Andreas Aarseth Kristoffersen, Trond Viggo Grøntvedt, Melissa Emery Thompson, Leif Edward Ottesen Kennair and Steven W. Gangestad, Oxytocin and vulnerable romantic relationships, Hormones and Behavior, 90, (64), (2017).
- Lauren M. Sippel, Casey E. Allington, Robert H. Pietrzak, Ilan Harpaz-Rotem, Linda C. Mayes and Miranda Olff, Oxytocin and Stress-related Disorders: Neurobiological Mechanisms and Treatment Opportunities, Chronic Stress, 1, (247054701668799), (2017).
- Daniel S. Quintana, Ingrid Dieset, Torbjørn Elvsåshagen, Lars T. Westlye and Ole A. Andreassen, Oxytocin system dysfunction as a common mechanism underlying metabolic syndrome and psychiatric symptoms in schizophrenia and bipolar disorders, Frontiers in Neuroendocrinology, 10.1016/j.yfrne.2016.12.004, 45, (1-10), (2017).
- Jenni Leppanen, Kah Wee Ng, Kate Tchanturia and Janet Treasure, Meta-analysis of the effects of intranasal oxytocin on interpretation and expression of emotions, Neuroscience & Biobehavioral Reviews, 78, (125), (2017).
- Lauren J. Human, Katherine R. Thorson, Joshua D. Woolley and Wendy Berry Mendes, Combining oxytocin administration and positive emotion inductions: Examining social perception and analytical performance, Hormones and Behavior, 90, (120), (2017).
- Michaela Pfundmair, Wiebke Erk and Annika Reinelt, “Lie to me”—Oxytocin impairs lie detection between sexes, Psychoneuroendocrinology, 84, (135), (2017).
- Amanda Venta, Carolyn Ha, Salome Vanwoerden, Elizabeth Newlin, Lane Strathearn and Carla Sharp, Paradoxical Effects of Intranasal Oxytocin on Trust in Inpatient and Community Adolescents, Journal of Clinical Child & Adolescent Psychology, (1), (2017).
- Jean-Loup Rault, Marleen van den Munkhof and Femke T. A. Buisman-Pijlman, Oxytocin as an Indicator of Psychological and Social Well-Being in Domesticated Animals: A Critical Review, Frontiers in Psychology, 8, (2017).
- J. Leppanen, V. Cardi, K. W. Ng, Y. Paloyelis, D. Stein, K. Tchanturia and J. Treasure, Effects of Intranasal Oxytocin on the Interpretation and Expression of Emotions in Anorexia Nervosa, Journal of Neuroendocrinology, 29, 3, (2017).
- Gregory Francis, Implications of “Too Good to Be True” for Replication, Theoretical Claims, and Experimental Design: An Example Using Prominent Studies of Racial Bias, Frontiers in Psychology, 7, (2016).
- Daniel S. Quintana, Lars T. Westlye, Dag Alnæs, Øyvind G. Rustan, Tobias Kaufmann, Knut T. Smerud, Ramy A. Mahmoud, Per G. Djupesland and Ole A. Andreassen, Low dose intranasal oxytocin delivered with Breath Powered device dampens amygdala response to emotional stimuli: A peripheral effect-controlled within-subjects randomized dose-response fMRI trial, Psychoneuroendocrinology, 10.1016/j.psyneuen.2016.04.010, 69, (180-188), (2016).
- Daniel S. Quintana, Tim Outhred, Lars T. Westlye, Gin S. Malhi and Ole A. Andreassen, The impact of oxytocin administration on brain activity: a systematic review and meta-analysis protocol, Systematic Reviews, 5, 1, (2016).
- Boris Kotchoubey, Felix Tretter, Hans A. Braun, Thomas Buchheim, Andreas Draguhn, Thomas Fuchs, Felix Hasler, Heiner Hastedt, Thilo Hinterberger, Georg Northoff, Ingo Rentschler, Stephan Schleim, Stephan Sellmaier, Ludger Tebartz Van Elst and Wolfgang Tschacher, Methodological Problems on the Way to Integrative Human Neuroscience, Frontiers in Integrative Neuroscience, 10, (2016).
