Fecal microbiota transplantation for fulminant Clostridium difficile infection in an allogeneic stem cell transplant patient
Corresponding Author
K. Neemann
Infectious Diseases Division, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
Correspondence to: Kari Neemann, MD, Infectious Diseases Division, 5400 Nebraska Medical Center, Omaha, NE 68198-5400, USA
Tel: 402 559 8650
Fax: 402 559 5518
E-mail: [email protected]
Search for more papers by this authorD.D. Eichele
Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
Search for more papers by this authorP.W. Smith
Infectious Diseases Division, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
Search for more papers by this authorR. Bociek
Section of Hematology/Oncology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
Search for more papers by this authorM. Akhtari
Section of Hematology/Oncology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
Search for more papers by this authorA. Freifeld
Infectious Diseases Division, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
Search for more papers by this authorCorresponding Author
K. Neemann
Infectious Diseases Division, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
Correspondence to: Kari Neemann, MD, Infectious Diseases Division, 5400 Nebraska Medical Center, Omaha, NE 68198-5400, USA
Tel: 402 559 8650
Fax: 402 559 5518
E-mail: [email protected]
Search for more papers by this authorD.D. Eichele
Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
Search for more papers by this authorP.W. Smith
Infectious Diseases Division, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
Search for more papers by this authorR. Bociek
Section of Hematology/Oncology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
Search for more papers by this authorM. Akhtari
Section of Hematology/Oncology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
Search for more papers by this authorA. Freifeld
Infectious Diseases Division, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
Search for more papers by this authorAbstract
We present a case of severe Clostridium difficile infection (CDI) in a non-neutropenic allogeneic hematopoietic stem cell transplant recipient who was treated successfully with fecal microbiota therapy after standard pharmacologic therapy had failed. Following naso-jejunal instillation of donor stool, the patient's symptoms resolved within 48 h. Bowel resection was averted. This is the first case in the literature, to our knowledge, to describe fecal microbiota therapy in a profoundly immunocompromised host with severe CDI. We propose that fecal microbiota therapy be considered as a therapeutic option in immunosuppressed patients with refractory severe CDI.
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