Concise Report
Iridium‐Catalyzed Enantioselective C(sp3)–H Borylation of Cyclobutanes
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Summary of main observation and conclusion
We herein report the first example of iridium‐catalyzed enantioselective C(sp3)–H borylation of cyclobutanes using benzoxazoline as the directing group. The combination of a chiral bidentate boryl ligand and an iridium precursor has found to effectively catalyze C(sp3)–H borylation to afford a variety of cyclobutylboronates with good to excellent enantioselectivities. We also demonstrate the synthetic utility of the current method by converting the stereogenic C—B bond to other functionalities.
