Communication

Microbubbles from Gas‐Generating Perfluorohexane Nanoemulsions for Targeted Temperature‐Sensitive Ultrasonography and Synergistic HIFU Ablation of Tumors

Institute of Ultrasound Imaging, Second Affiliated Hospital of Chongqing, Medical University, Chongqing, 400010, P. R. China

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Zhigang Wang

Institute of Ultrasound Imaging, Second Affiliated Hospital of Chongqing, Medical University, Chongqing, 400010, P. R. China

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Yu Chen

State Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P. R. China.

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Hongxia Shen

Institute of Ultrasound Imaging, Second Affiliated Hospital of Chongqing, Medical University, Chongqing, 400010, P. R. China

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Zhenchun Luo

Institute of Ultrasound Imaging, Second Affiliated Hospital of Chongqing, Medical University, Chongqing, 400010, P. R. China

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Ao Li

Institute of Ultrasound Imaging, Second Affiliated Hospital of Chongqing, Medical University, Chongqing, 400010, P. R. China

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Qi Wang

Institute of Ultrasound Imaging, Second Affiliated Hospital of Chongqing, Medical University, Chongqing, 400010, P. R. China

College of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016, P. R. China.

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Haitao Ran

Institute of Ultrasound Imaging, Second Affiliated Hospital of Chongqing, Medical University, Chongqing, 400010, P. R. China

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Pan Li

Institute of Ultrasound Imaging, Second Affiliated Hospital of Chongqing, Medical University, Chongqing, 400010, P. R. China

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Weixiang Song

Institute of Ultrasound Imaging, Second Affiliated Hospital of Chongqing, Medical University, Chongqing, 400010, P. R. China

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Zhu Yang

Institute of Ultrasound Imaging, Second Affiliated Hospital of Chongqing, Medical University, Chongqing, 400010, P. R. China

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Hangrong Chen

State Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P. R. China.

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Zhibiao Wang

College of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016, P. R. China.

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Guangmin Lu

Department of Radiology, General Hospital of Nanjing Military Base, Nanjing, 210002, P. R. China.

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Yuanyi Zheng

Corresponding Author

E-mail address: zhengyuanyi@gmail.com

Institute of Ultrasound Imaging, Second Affiliated Hospital of Chongqing, Medical University, Chongqing, 400010, P. R. China

Institute of Ultrasound Imaging, Second Affiliated Hospital of Chongqing, Medical University, Chongqing, 400010, P. R. China.Search for more papers by this author

Yang Zhou

Institute of Ultrasound Imaging, Second Affiliated Hospital of Chongqing, Medical University, Chongqing, 400010, P. R. China

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Zhigang Wang

Institute of Ultrasound Imaging, Second Affiliated Hospital of Chongqing, Medical University, Chongqing, 400010, P. R. China

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Yu Chen

State Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P. R. China.

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Hongxia Shen

Institute of Ultrasound Imaging, Second Affiliated Hospital of Chongqing, Medical University, Chongqing, 400010, P. R. China

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Zhenchun Luo

Institute of Ultrasound Imaging, Second Affiliated Hospital of Chongqing, Medical University, Chongqing, 400010, P. R. China

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Ao Li

Institute of Ultrasound Imaging, Second Affiliated Hospital of Chongqing, Medical University, Chongqing, 400010, P. R. China

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Qi Wang

Institute of Ultrasound Imaging, Second Affiliated Hospital of Chongqing, Medical University, Chongqing, 400010, P. R. China

College of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016, P. R. China.

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Haitao Ran

Institute of Ultrasound Imaging, Second Affiliated Hospital of Chongqing, Medical University, Chongqing, 400010, P. R. China

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Pan Li

Institute of Ultrasound Imaging, Second Affiliated Hospital of Chongqing, Medical University, Chongqing, 400010, P. R. China

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Weixiang Song

Institute of Ultrasound Imaging, Second Affiliated Hospital of Chongqing, Medical University, Chongqing, 400010, P. R. China

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Zhu Yang

Institute of Ultrasound Imaging, Second Affiliated Hospital of Chongqing, Medical University, Chongqing, 400010, P. R. China

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Hangrong Chen

State Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P. R. China.

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Zhibiao Wang

College of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016, P. R. China.

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Guangmin Lu

Department of Radiology, General Hospital of Nanjing Military Base, Nanjing, 210002, P. R. China.

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Yuanyi Zheng

Corresponding Author

E-mail address: zhengyuanyi@gmail.com

Institute of Ultrasound Imaging, Second Affiliated Hospital of Chongqing, Medical University, Chongqing, 400010, P. R. China

Institute of Ultrasound Imaging, Second Affiliated Hospital of Chongqing, Medical University, Chongqing, 400010, P. R. China.Search for more papers by this author

First published: 21 June 2013

https://doi.org/10.1002/adma.201301655

Citations: 88

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Abstract

A special “small to big” temperature‐responsive phase‐transformation strategy based on the “acoustic droplet vaporization (ADV)” mechanism is developed for efficient targeted ultrasonography and synergistic high intensity focused ultrasound (HIFU) cancer surgery by engineering targeted nanoemulsions, which is systematically evaluated and successfully demonstrated in vitro, ex vivo, and in vivo.