Communication

A Prussian Blue‐Based Core–Shell Hollow‐Structured Mesoporous Nanoparticle as a Smart Theranostic Agent with Ultrahigh pH‐Responsive Longitudinal Relaxivity

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 200050 Shanghai, P. R. China

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Wei Gao

Second Affiliated Hospital of Chongqing Medical University, 400016 Chongqing, P. R. China

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Ming Ma

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 200050 Shanghai, P. R. China

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Meiying Wu

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 200050 Shanghai, P. R. China

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Linlin Zhang

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 200050 Shanghai, P. R. China

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Yuanyi Zheng

Second Affiliated Hospital of Chongqing Medical University, 400016 Chongqing, P. R. China

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Hangrong Chen

Corresponding Author

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 200050 Shanghai, P. R. China

E‐mail: hrchen@mail.sic.ac.cn, jlshi@mail.sic.ac.cn Search for more papers by this author

Jianlin Shi

Corresponding Author

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 200050 Shanghai, P. R. China

E‐mail: hrchen@mail.sic.ac.cn, jlshi@mail.sic.ac.cn Search for more papers by this author

Xiaojun Cai

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 200050 Shanghai, P. R. China

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Wei Gao

Second Affiliated Hospital of Chongqing Medical University, 400016 Chongqing, P. R. China

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Ming Ma

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 200050 Shanghai, P. R. China

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Meiying Wu

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 200050 Shanghai, P. R. China

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Linlin Zhang

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 200050 Shanghai, P. R. China

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Yuanyi Zheng

Second Affiliated Hospital of Chongqing Medical University, 400016 Chongqing, P. R. China

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Hangrong Chen

Corresponding Author

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 200050 Shanghai, P. R. China

E‐mail: hrchen@mail.sic.ac.cn, jlshi@mail.sic.ac.cn Search for more papers by this author

Jianlin Shi

Corresponding Author

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 200050 Shanghai, P. R. China

E‐mail: hrchen@mail.sic.ac.cn, jlshi@mail.sic.ac.cn Search for more papers by this author

First published: 22 September 2015

https://doi.org/10.1002/adma.201503381

Citations: 102

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Abstract

Novel core–shell hollow mesoporous Prussian blue @ Mn‐containing Prussian blue analogue (HMPB@MnPBA) nanoparticles, designated as HMPB‐Mn) as an intelligent theranostic nanoagent, are successfully constructed by coating a similarly crystal‐structured MnPBA onto HMPB. This can be used as a pH‐responsive T ₁‐weighted magnetic resonance imaging contrast agent with ultrahigh longitudinal relaxivity (r ₁ = 7.43 m m ⁻¹ s⁻¹), and achieves the real‐time monitoring of drug release.