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Advanced Materials
Communication

Injectable 2D MoS2‐Integrated Drug Delivering Implant for Highly Efficient NIR‐Triggered Synergistic Tumor Hyperthermia

Shige Wang

State Key Laboratory of High Performance Ceramic and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Science, Shanghai, 200050 P. R. China

Tin Ka Ping College of Science, University of Shanghai for Science and Technology, Shanghai, 200093 P. R. China

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Yu Chen

Corresponding Author

State Key Laboratory of High Performance Ceramic and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Science, Shanghai, 200050 P. R. China

E‐mail: chenyu@mail.sic.ac.cn, hrchen@mail.sic.ac.cnSearch for more papers by this author
Xiang Li

Department of Breast‐Thyroid Surrey, Shanghai First People Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200080 P. R. China

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Wei Gao

Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400016 P. R. China

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Linlin Zhang

State Key Laboratory of High Performance Ceramic and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Science, Shanghai, 200050 P. R. China

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Jun Liu

Department of Breast‐Thyroid Surrey, Shanghai First People Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200080 P. R. China

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Yuanyi Zheng

Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400016 P. R. China

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Hangrong Chen

Corresponding Author

State Key Laboratory of High Performance Ceramic and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Science, Shanghai, 200050 P. R. China

E‐mail: chenyu@mail.sic.ac.cn, hrchen@mail.sic.ac.cnSearch for more papers by this author
Jianlin Shi

State Key Laboratory of High Performance Ceramic and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Science, Shanghai, 200050 P. R. China

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First published: 08 October 2015
https://doi.org/10.1002/adma.201503869
Citations: 141
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Abstract

MoS2 nanosheets and a doxorubicin (DOX)‐containing poly (lactic‐co ‐glycolic acid) (PLGA)/MoS2/DOX composite implant are successfully constructed based on the unique phase‐changing behavior of PLGA/MoS2/DOX oleosol within tumors. The fast phase transformation can firmly restrict MoS2 and DOX within tumors, and the integrated MoS2 and DOX can endow the implant with high synergistic photothermal and chemotherapeutic efficiency against tumors.

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