Brief Research Communication
Failure to replicate effect of kibra on human memory in two large cohorts of European origin*
*
Please cite this article as follows: Need AC, Attix DK, McEvoy JM, Cirulli ET, Linney KN, Wagoner AP, Gumbs CE, Giegling I, Möller H‐J, Francks C, Muglia P, Roses A, Gibson G, Weale ME, Rujescu D, Goldstein DB. 2007. Failure to Replicate Effect of Kibra on Human Memory in Two Large Cohorts of European Origin. Am J Med Genet Part B 147B:667–668.
Abstract
It was recently suggested that the Kibra polymorphism rs17070145 has a strong effect on multiple episodic memory tasks in humans. We attempted to replicate this using two cohorts of European genetic origin (n = 319 and n = 365). We found no association with either the original SNP or a set of tagging SNPs in the Kibra gene with multiple verbal memory tasks, including one that was an exact replication (Auditory Verbal Learning Task, AVLT). These results suggest that Kibra does not have a strong and general effect on human memory. © 2008 Wiley‐Liss, Inc.
Citing Literature
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