Zuschrift
yDNA: A New Geometry for Size‐Expanded Base Pairs*
*
This work was supported by the U.S. National Institutes of Health (GM63587) and by an Abbott Laboratories Graduate Research Fellowship to H.L.
Abstract
Neue Paarung: Die Insertion eines Benzolrings in den natürlichen Adeninheterocyclus führt zum Analogon yA und zur Bildung von Basenpaaren, die 2.4 Å breiter sind als die natürlichen Basenpaare (siehe Struktur). Die Paare yA⋅T und T⋅yA können sich zu kooperativen Helices zusammenlagern, die deutlich stabiler als natürliche DNA sind. Demzufolge könnte yDNA ein Kandidat für ein neues genetisches System sein.
Citing Literature
Number of times cited: 11
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