A Purine‐like Nickel(II) Base Pair for DNA*
This work was supported by DOD/DARPA/DMEA under award no. DMEA90‐02‐2‐0216 and the NASA exobiology program under award no. NAG5‐9812.
Abstract
Mit dem Metall in der Mitte: Ein Metallobasenpaar auf der Grundlage von 6‐Pyridylpurin (Purp) wurde synthetisiert und charakterisiert. PurP bevorzugt Nickel(II) gegenüber anderen zweiwertigen Ionen, und mit hoher Kombinationsselektivität entsteht ein Basenpaar, das die natürlichen Watson‐Crick‐Paare an Stabilität übertrifft. Rechnungen bestätigen ähnliche dreidimensionale Strukturen für PurP⋅Ni2+⋅PurP (siehe Bild) und die natürlichen Basenpaare.
Number of times cited: 47
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