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Angewandte Chemie
Zuschrift

A Purine‐like Nickel(II) Base Pair for DNA*

Christopher Switzer Prof.

E-mail address:christopher.switzer@ucr.edu

Department of Chemistry, University of California, Riverside, CA 92521, USA, Fax: (+1) 951‐787‐2435

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Surajit Sinha

Department of Chemistry, University of California, Riverside, CA 92521, USA, Fax: (+1) 951‐787‐2435

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Paul H. Kim

Department of Chemistry, University of California, Riverside, CA 92521, USA, Fax: (+1) 951‐787‐2435

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Benjamin D. Heuberger

Department of Chemistry, University of California, Riverside, CA 92521, USA, Fax: (+1) 951‐787‐2435

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First published: 28 January 2005
Cited by: 47
*

This work was supported by DOD/DARPA/DMEA under award no. DMEA90‐02‐2‐0216 and the NASA exobiology program under award no. NAG5‐9812.

Abstract

Mit dem Metall in der Mitte: Ein Metallobasenpaar auf der Grundlage von 6‐Pyridylpurin (Purp) wurde synthetisiert und charakterisiert. PurP bevorzugt Nickel(II) gegenüber anderen zweiwertigen Ionen, und mit hoher Kombinationsselektivität entsteht ein Basenpaar, das die natürlichen Watson‐Crick‐Paare an Stabilität übertrifft. Rechnungen bestätigen ähnliche dreidimensionale Strukturen für PurP⋅Ni2+⋅PurP (siehe Bild) und die natürlichen Basenpaare.

Number of times cited: 47

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