DNA‐Metall‐Basenpaare
Abstract
Neuere Entwicklungen, die darauf abzielen, DNA als funktionelles Baumaterial für Nanoobjekte zu verwenden, zeigen vielversprechende Ergebnisse. In der Vergangenheit wurden molekulare DNA‐Nanoarchitekturen aus unmodifizierten oder bestenfalls endgruppenmodifizierten Oligonucleotiden aufgebaut, sodass derzeit die Entwicklung von funktionalisierten DNA‐Strukturen im Rampenlicht der Forschung steht. Eine der neuesten Entwicklungen in diese Richtung ist der Austausch der kanonischen Watson‐Crick‐Basenpaare durch Metallkomplexe zur Erzeugung von Metall‐Basenpaaren, die DNA‐Nanostrukturen magnetische oder elektrisch leitende Eigenschaften verleihen könnten. Dieser Kurzaufsatz fasst die Forschung auf diesem Gebiet zusammen, die vor fast 45 Jahren mit der Untersuchung der Interaktion von Metallen mit unmodifizierter DNA begann und nun ihren Höhepunkt in der Synthese künstlicher, ligandenähnlicher Nucleobasen findet, die bereits imstande sind, bis zu zehn Metallionen innerhalb eines einzelnen DNA‐Doppelstrangs programmierbar zu koordinieren.
Number of times cited: 138
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- Joanne I. Yeh, Ehmke Pohl, Daphne Truan, Wei He, George M. Sheldrick, Shoucheng Du and Catalina Achim, The Crystal Structure of Non‐Modified and Bipyridine‐Modified PNA Duplexes, Chemistry – A European Journal, 16, 39, (11867-11875), (2010).
- Hidehito Urata, Eriko Yamaguchi, Tatsuya Funai, Yuriko Matsumura and Shun‐ichi Wada, Incorporation of Thymine Nucleotides by DNA Polymerases through T–HgII–T Base Pairing, Angewandte Chemie International Edition, 49, 37, (6516-6519), (2010).
- Alexandru Rotaru, Subrata Dutta, Elmar Jentzsch, Kurt Gothelf and Andriy Mokhir, Selektive dsDNA‐gesteuerte Bildung von Kupfer‐Nanopartikeln in Lösung, Angewandte Chemie, 122, 33, (5799-5802), (2010).
- Guido H. Clever, Stephan J. Reitmeier, Thomas Carell and Olav Schiemann, Antiferromagnetic Coupling of Stacked CuII–Salen Complexes in DNA, Angewandte Chemie, 122, 29, (5047-5049), (2010).
- Hidetaka Torigoe, Akira Ono and Tetsuo Kozasa, HgII Ion Specifically Binds with T:T Mismatched Base Pair in Duplex DNA, Chemistry – A European Journal, 16, 44, (13218-13225), (2010).
- Alexandru Rotaru, Subrata Dutta, Elmar Jentzsch, Kurt Gothelf and Andriy Mokhir, Selective dsDNA‐Templated Formation of Copper Nanoparticles in Solution, Angewandte Chemie International Edition, 49, 33, (5665-5667), (2010).
- Guido H. Clever, Stephan J. Reitmeier, Thomas Carell and Olav Schiemann, Antiferromagnetic Coupling of Stacked CuII–Salen Complexes in DNA, Angewandte Chemie International Edition, 49, 29, (4927-4929), (2010).
- Ki Soo Park, Cheulhee Jung and Hyun Gyu Park, “Illusionary” Polymerase Activity Triggered by Metal Ions: Use for Molecular Logic‐Gate Operations, Angewandte Chemie International Edition, 49, 50, (9757-9760), (2010).
- Hidehito Urata, Eriko Yamaguchi, Tatsuya Funai, Yuriko Matsumura and Shun‐ichi Wada, Incorporation of Thymine Nucleotides by DNA Polymerases through T–HgII–T Base Pairing, Angewandte Chemie, 122, 37, (6666-6669), (2010).
- Ki Soo Park, Cheulhee Jung and Hyun Gyu Park, “Illusionary” Polymerase Activity Triggered by Metal Ions: Use for Molecular Logic‐Gate Operations, Angewandte Chemie, 122, 50, (9951-9954), (2010).
- Sumana Ghosh and Eric Defrancq, Metal‐Complex/DNA Conjugates: A Versatile Building Block for DNA Nanoarrays, Chemistry – A European Journal, 16, 43, (12780-12787), (2010).
- Itaru Okamoto, Kenji Iwamoto, Yuko Watanabe, Yoko Miyake and Akira Ono, Metal‐Ion Selectivity of Chemically Modified Uracil Pairs in DNA Duplexes, Angewandte Chemie, 121, 9, (1676-1679), (2009).
- Hua Yang, Andrzej Z. Rys, Christopher K. McLaughlin and Hanadi F. Sleiman, Templated Ligand Environments for the Selective Incorporation of Different Metals into DNA, Angewandte Chemie, 121, 52, (10103-10107), (2009).
- Lily Bahshi, Ronit Freeman, Ron Gill and Itamar Willner, Optical Detection of Glucose by Means of Metal Nanoparticles or Semiconductor Quantum Dots, Small, 5, 6, (676-680), (2009).
- Andy C. Laungani, Manfred Keller, John M. Slattery, Ingo Krossing and Bernhard Breit, Cooperative Effect of a Classical and a Weak Hydrogen Bond for the Metal‐Induced Construction of a Self‐Assembled β‐Turn Mimic, Chemistry � A European Journal, 15, 40, (10405-10422), (2009).
- Nikolay A. Grigorenko and Christian J. Leumann, 2‐Phenanthrenyl–DNA: Synthesis, Pairing, and Fluorescence Properties, Chemistry � A European Journal, 15, 3, (639-645), (2008).
- Hua Yang, Andrzej Z. Rys, Christopher K. McLaughlin and Hanadi F. Sleiman, Templated Ligand Environments for the Selective Incorporation of Different Metals into DNA, Angewandte Chemie International Edition, 48, 52, (9919-9923), (2009).
- Ronit Freeman, Tali Finder and Itamar Willner, Multiplexed Analysis of Hg2+ and Ag+ Ions by Nucleic Acid Functionalized CdSe/ZnS Quantum Dots and Their Use for Logic Gate Operations, Angewandte Chemie International Edition, 48, 42, (7818-7821), (2009).
- Itaru Okamoto, Kenji Iwamoto, Yuko Watanabe, Yoko Miyake and Akira Ono, Metal‐Ion Selectivity of Chemically Modified Uracil Pairs in DNA Duplexes, Angewandte Chemie International Edition, 48, 9, (1648-1651), (2009).
- Yusuke Takezawa, Wakana Maeda, Kentaro Tanaka and Mitsuhiko Shionoya, Discrete Self‐Assembly of Iron(III) Ions inside Triple‐Stranded Artificial DNA, Angewandte Chemie International Edition, 48, 6, (1081-1084), (2008).
- Sairam S. Mallajosyula and Swapan K. Pati, Conformational Tuning of Magnetic Interactions in Metal–DNA Complexes, Angewandte Chemie International Edition, 48, 27, (4977-4981), (2009).
- Sairam S. Mallajosyula and Swapan K. Pati, Conformational Tuning of Magnetic Interactions in Metal–DNA Complexes, Angewandte Chemie, 121, 27, (5077-5081), (2009).
- Tao Li, Lili Shi, Erkang Wang and Shaojun Dong, Silver‐Ion‐Mediated DNAzyme Switch for the Ultrasensitive and Selective Colorimetric Detection of Aqueous Ag+ and Cysteine, Chemistry � A European Journal, 15, 14, (3347-3350), (2009).
- Ronit Freeman, Tali Finder and Itamar Willner, Multiplexed Analysis of Hg2+ and Ag+ Ions by Nucleic Acid Functionalized CdSe/ZnS Quantum Dots and Their Use for Logic Gate Operations, Angewandte Chemie, 121, 42, (7958-7961), (2009).
- Yusuke Takezawa, Wakana Maeda, Kentaro Tanaka and Mitsuhiko Shionoya, Discrete Self‐Assembly of Iron(III) Ions inside Triple‐Stranded Artificial DNA, Angewandte Chemie, 121, 6, (1101-1104), (2008).
- Jens Müller, Nucleinsäuren mit metallvermittelten Basenpaaren, Nachrichten aus der Chemie, 57, 2, (120-123), (2009).
- Di Li, Agnieszka Wieckowska and Itamar Willner, Optical Analysis of Hg2+ Ions by Oligonucleotide–Gold‐Nanoparticle Hybrids and DNA‐Based Machines, Angewandte Chemie, 120, 21, (3991-3995), (2008).
- , Organic Chemistry: K. Nakanishi Honored / Biochemistry: T. Carell Awarded / Chemistry: K. Müllen Elected, Angewandte Chemie International Edition, 47, 5, (822-823), (2008).
- Alain Zahn and Christian J. Leumann, Recognition Properties of Donor‐ and Acceptor‐Modified Biphenyl‐DNA, Chemistry – A European Journal, 14, 4, (1087-1094), (2007).
- Di Li, Agnieszka Wieckowska and Itamar Willner, Optical Analysis of Hg2+ Ions by Oligonucleotide–Gold‐Nanoparticle Hybrids and DNA‐Based Machines, Angewandte Chemie International Edition, 47, 21, (3927-3931), (2008).
- Benjamin Elias, Joseph C. Genereux and Jacqueline K. Barton, Ping‐Pong Electron Transfer through DNA, Angewandte Chemie International Edition, 47, 47, (9067-9070), (2008).
- Rolf W. Saalfrank, Christine Spitzlei, Andreas Scheurer, Harald Maid, Frank W. Heinemann and Frank Hampel, Enantiospecific Syntheses of Copper Cubanes, Double‐Stranded Copper/Palladium Helicates, and a (Dilithium)–Dinickel Coronate from Enantiomerically Pure Bis‐1,3‐diketones—Solid‐State Self‐Organization Towards Wirelike Copper/Palladium Strands, Chemistry – A European Journal, 14, 5, (1472-1481), (2008).
- Marcel Hollenstein, Christopher Hipolito, Curtis Lam, David Dietrich and David M. Perrin, A Highly Selective DNAzyme Sensor for Mercuric Ions, Angewandte Chemie International Edition, 47, 23, (4346-4350), (2008).
- , Organische Chemie: K. Nakanishi geehrt / Biochemie: T. Carell ausgezeichnet / Chemie: K. Müllen gewählt, Angewandte Chemie, 120, 5, (834-835), (2008).
- Hua Yang and Hanadi F. Sleiman, Templated Synthesis of Highly Stable, Electroactive, and Dynamic Metal–DNA Branched Junctions, Angewandte Chemie, 120, 13, (2477-2480), (2008).
- Benjamin Elias, Joseph C. Genereux and Jacqueline K. Barton, Ping‐Pong Electron Transfer through DNA, Angewandte Chemie, 120, 47, (9207-9210), (2008).
- Hua Yang and Hanadi F. Sleiman, Templated Synthesis of Highly Stable, Electroactive, and Dynamic Metal–DNA Branched Junctions, Angewandte Chemie International Edition, 47, 13, (2443-2446), (2008).
- Marcel Hollenstein, Christopher Hipolito, Curtis Lam, David Dietrich and David M. Perrin, A Highly Selective DNAzyme Sensor for Mercuric Ions, Angewandte Chemie, 120, 23, (4418-4422), (2008).
- Ayhan Üngördü and Nurten Tezer, Effect on frontier molecular orbitals of substituents in 5-position of uracil base pairs in vacuum and water, Journal of Theoretical and Computational Chemistry, 10.1142/S0219633617500663, (1750066), (2017).




