Rücktitelbild: Visualizing an Ultra‐Weak Protein–Protein Interaction in Phosphorylation Signaling (Angew. Chem. 43/2014)
CAS Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Center for Magnetic Resonance, State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Wuhan Institute of Physics and Mathematics of the Chinese Academy of Sciences, Xiao‐Hong Shan, Wuhan, Hubei 430071 (China) http://tanglab.wipm.ac.cn
These authors contributed equally to this work.
Search for more papers by this authorDepartment of Pharmacology and Institute of Neuroscience, Zhejiang University School of Medicine, Yu‐Hang‐Tang Road, Hangzhou, Zhejiang 310028 (China)
These authors contributed equally to this work.
Search for more papers by this authorCAS Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Center for Magnetic Resonance, State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Wuhan Institute of Physics and Mathematics of the Chinese Academy of Sciences, Xiao‐Hong Shan, Wuhan, Hubei 430071 (China) http://tanglab.wipm.ac.cn
Search for more papers by this authorCAS Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Center for Magnetic Resonance, State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Wuhan Institute of Physics and Mathematics of the Chinese Academy of Sciences, Xiao‐Hong Shan, Wuhan, Hubei 430071 (China) http://tanglab.wipm.ac.cn
Search for more papers by this authorCAS Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Center for Magnetic Resonance, State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Wuhan Institute of Physics and Mathematics of the Chinese Academy of Sciences, Xiao‐Hong Shan, Wuhan, Hubei 430071 (China) http://tanglab.wipm.ac.cn
Search for more papers by this authorCAS Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Center for Magnetic Resonance, State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Wuhan Institute of Physics and Mathematics of the Chinese Academy of Sciences, Xiao‐Hong Shan, Wuhan, Hubei 430071 (China) http://tanglab.wipm.ac.cn
Search for more papers by this authorCAS Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Center for Magnetic Resonance, State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Wuhan Institute of Physics and Mathematics of the Chinese Academy of Sciences, Xiao‐Hong Shan, Wuhan, Hubei 430071 (China) http://tanglab.wipm.ac.cn
Search for more papers by this authorCAS Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Center for Magnetic Resonance, State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Wuhan Institute of Physics and Mathematics of the Chinese Academy of Sciences, Xiao‐Hong Shan, Wuhan, Hubei 430071 (China) http://tanglab.wipm.ac.cn
Search for more papers by this authorCAS Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Center for Magnetic Resonance, State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Wuhan Institute of Physics and Mathematics of the Chinese Academy of Sciences, Xiao‐Hong Shan, Wuhan, Hubei 430071 (China) http://tanglab.wipm.ac.cn
Search for more papers by this authorCAS Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Center for Magnetic Resonance, State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Wuhan Institute of Physics and Mathematics of the Chinese Academy of Sciences, Xiao‐Hong Shan, Wuhan, Hubei 430071 (China) http://tanglab.wipm.ac.cn
Search for more papers by this authorCAS Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Center for Magnetic Resonance, State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Wuhan Institute of Physics and Mathematics of the Chinese Academy of Sciences, Xiao‐Hong Shan, Wuhan, Hubei 430071 (China) http://tanglab.wipm.ac.cn
Search for more papers by this authorCAS Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Center for Magnetic Resonance, State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Wuhan Institute of Physics and Mathematics of the Chinese Academy of Sciences, Xiao‐Hong Shan, Wuhan, Hubei 430071 (China) http://tanglab.wipm.ac.cn
Search for more papers by this authorCAS Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Center for Magnetic Resonance, State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Wuhan Institute of Physics and Mathematics of the Chinese Academy of Sciences, Xiao‐Hong Shan, Wuhan, Hubei 430071 (China) http://tanglab.wipm.ac.cn
Search for more papers by this authorCAS Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Center for Magnetic Resonance, State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Wuhan Institute of Physics and Mathematics of the Chinese Academy of Sciences, Xiao‐Hong Shan, Wuhan, Hubei 430071 (China) http://tanglab.wipm.ac.cn
Search for more papers by this authorCorresponding Author
E-mail address: weiping601@zju.edu.cn
Department of Pharmacology and Institute of Neuroscience, Zhejiang University School of Medicine, Yu‐Hang‐Tang Road, Hangzhou, Zhejiang 310028 (China)
These authors contributed equally to this work.
Wei‐Ping Zhang, Department of Pharmacology and Institute of Neuroscience, Zhejiang University School of Medicine, Yu‐Hang‐Tang Road, Hangzhou, Zhejiang 310028 (China)
Chun Tang, CAS Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Center for Magnetic Resonance, State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Wuhan Institute of Physics and Mathematics of the Chinese Academy of Sciences, Xiao‐Hong Shan, Wuhan, Hubei 430071 (China) http://tanglab.wipm.ac.cn
Search for more papers by this authorCorresponding Author
E-mail address: tanglab@wipm.ac.cn
CAS Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Center for Magnetic Resonance, State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Wuhan Institute of Physics and Mathematics of the Chinese Academy of Sciences, Xiao‐Hong Shan, Wuhan, Hubei 430071 (China) http://tanglab.wipm.ac.cn
Wei‐Ping Zhang, Department of Pharmacology and Institute of Neuroscience, Zhejiang University School of Medicine, Yu‐Hang‐Tang Road, Hangzhou, Zhejiang 310028 (China)
Chun Tang, CAS Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Center for Magnetic Resonance, State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Wuhan Institute of Physics and Mathematics of the Chinese Academy of Sciences, Xiao‐Hong Shan, Wuhan, Hubei 430071 (China) http://tanglab.wipm.ac.cn
Search for more papers by this authorCAS Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Center for Magnetic Resonance, State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Wuhan Institute of Physics and Mathematics of the Chinese Academy of Sciences, Xiao‐Hong Shan, Wuhan, Hubei 430071 (China) http://tanglab.wipm.ac.cn
These authors contributed equally to this work.
Search for more papers by this authorDepartment of Pharmacology and Institute of Neuroscience, Zhejiang University School of Medicine, Yu‐Hang‐Tang Road, Hangzhou, Zhejiang 310028 (China)
These authors contributed equally to this work.
Search for more papers by this authorCAS Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Center for Magnetic Resonance, State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Wuhan Institute of Physics and Mathematics of the Chinese Academy of Sciences, Xiao‐Hong Shan, Wuhan, Hubei 430071 (China) http://tanglab.wipm.ac.cn
Search for more papers by this authorCAS Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Center for Magnetic Resonance, State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Wuhan Institute of Physics and Mathematics of the Chinese Academy of Sciences, Xiao‐Hong Shan, Wuhan, Hubei 430071 (China) http://tanglab.wipm.ac.cn
Search for more papers by this authorCAS Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Center for Magnetic Resonance, State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Wuhan Institute of Physics and Mathematics of the Chinese Academy of Sciences, Xiao‐Hong Shan, Wuhan, Hubei 430071 (China) http://tanglab.wipm.ac.cn
Search for more papers by this authorCAS Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Center for Magnetic Resonance, State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Wuhan Institute of Physics and Mathematics of the Chinese Academy of Sciences, Xiao‐Hong Shan, Wuhan, Hubei 430071 (China) http://tanglab.wipm.ac.cn
Search for more papers by this authorCAS Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Center for Magnetic Resonance, State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Wuhan Institute of Physics and Mathematics of the Chinese Academy of Sciences, Xiao‐Hong Shan, Wuhan, Hubei 430071 (China) http://tanglab.wipm.ac.cn
Search for more papers by this authorCAS Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Center for Magnetic Resonance, State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Wuhan Institute of Physics and Mathematics of the Chinese Academy of Sciences, Xiao‐Hong Shan, Wuhan, Hubei 430071 (China) http://tanglab.wipm.ac.cn
Search for more papers by this authorCAS Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Center for Magnetic Resonance, State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Wuhan Institute of Physics and Mathematics of the Chinese Academy of Sciences, Xiao‐Hong Shan, Wuhan, Hubei 430071 (China) http://tanglab.wipm.ac.cn
Search for more papers by this authorCAS Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Center for Magnetic Resonance, State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Wuhan Institute of Physics and Mathematics of the Chinese Academy of Sciences, Xiao‐Hong Shan, Wuhan, Hubei 430071 (China) http://tanglab.wipm.ac.cn
Search for more papers by this authorCAS Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Center for Magnetic Resonance, State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Wuhan Institute of Physics and Mathematics of the Chinese Academy of Sciences, Xiao‐Hong Shan, Wuhan, Hubei 430071 (China) http://tanglab.wipm.ac.cn
Search for more papers by this authorCAS Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Center for Magnetic Resonance, State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Wuhan Institute of Physics and Mathematics of the Chinese Academy of Sciences, Xiao‐Hong Shan, Wuhan, Hubei 430071 (China) http://tanglab.wipm.ac.cn
Search for more papers by this authorCAS Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Center for Magnetic Resonance, State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Wuhan Institute of Physics and Mathematics of the Chinese Academy of Sciences, Xiao‐Hong Shan, Wuhan, Hubei 430071 (China) http://tanglab.wipm.ac.cn
Search for more papers by this authorCAS Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Center for Magnetic Resonance, State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Wuhan Institute of Physics and Mathematics of the Chinese Academy of Sciences, Xiao‐Hong Shan, Wuhan, Hubei 430071 (China) http://tanglab.wipm.ac.cn
Search for more papers by this authorCorresponding Author
E-mail address: weiping601@zju.edu.cn
Department of Pharmacology and Institute of Neuroscience, Zhejiang University School of Medicine, Yu‐Hang‐Tang Road, Hangzhou, Zhejiang 310028 (China)
These authors contributed equally to this work.
Wei‐Ping Zhang, Department of Pharmacology and Institute of Neuroscience, Zhejiang University School of Medicine, Yu‐Hang‐Tang Road, Hangzhou, Zhejiang 310028 (China)
Chun Tang, CAS Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Center for Magnetic Resonance, State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Wuhan Institute of Physics and Mathematics of the Chinese Academy of Sciences, Xiao‐Hong Shan, Wuhan, Hubei 430071 (China) http://tanglab.wipm.ac.cn
Search for more papers by this authorCorresponding Author
E-mail address: tanglab@wipm.ac.cn
CAS Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Center for Magnetic Resonance, State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Wuhan Institute of Physics and Mathematics of the Chinese Academy of Sciences, Xiao‐Hong Shan, Wuhan, Hubei 430071 (China) http://tanglab.wipm.ac.cn
Wei‐Ping Zhang, Department of Pharmacology and Institute of Neuroscience, Zhejiang University School of Medicine, Yu‐Hang‐Tang Road, Hangzhou, Zhejiang 310028 (China)
Chun Tang, CAS Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Center for Magnetic Resonance, State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Wuhan Institute of Physics and Mathematics of the Chinese Academy of Sciences, Xiao‐Hong Shan, Wuhan, Hubei 430071 (China) http://tanglab.wipm.ac.cn
Search for more papers by this authorAbstract
Im Gedränge der zellulären Umgebung …︁ …︁ geben Proteine Signale weiter, indem sie kurzzeitig, aber spezifisch miteinander wechselwirken. C. Tang, W.‐P. Zhang et al. zeigen in der Zuschrift auf S. 11685 ff., dass eine Phosphorylierung zwischen zwei Proteinen mit einer Bindungsaffinität von nur 25 mM und einer Lebensdauer ihres Komplexes im μs‐ bis ms‐Bereich stattfinden kann; die Werte für alle bekannten Protein‐Protein‐Wechselwirkungen sind um eine Größenordnung höher. Solche schwachen, flüchtigen Wechselwirkungen könnten bei Signalproteinen vorherrschen.
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