Communication
yDNA: A New Geometry for Size‐Expanded Base Pairs*
*
This work was supported by the U.S. National Institutes of Health (GM63587) and by an Abbott Laboratories Graduate Research Fellowship to H.L.
Abstract
Room for expansion: Insertion of a benzene ring into the natural adenine heterocycle to generate the analogue yA results in the formation of base pairs that are 2.4 Å wider than natural ones (see structure). Melting temperature and free energy data show that yA⋅T and T⋅yA pairs can self‐assemble into cooperative helices that are considerably more stable than natural DNA. Thus, yDNA may be a candidate for a new genetic system.
Citing Literature
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