Communication
Synthesis of 1,8‐Naphthyridine C‐Nucleosides and Their Base‐Pairing Properties in Oligodeoxynucleotides: Thermally Stable Naphthyridine:Imidazopyridopyrimidine Base‐Pairing Motifs*
*
This work was supported in part by a Grant‐in‐Aid for Scientific Research on Priority Areas and Encouragement of Young Scientists from the Ministry of Education, Science, Sports, and Culture of Japan. This paper constitutes Part 229 of Nucleosides and Nucleotides. Part 228 is reference [15].
Abstract
Out with the old, in with the new: Novel 1,8‐naphthyridine C‐nucleosides, Na‐NO and Na‐ON (see formulae), were synthesized through Heck coupling reactions. Oligodeoxynucleotides containing the Na‐NO and Na‐ON nucleosides formed extremely stable duplexes by the base‐pairing motifs Na‐NO:Im‐ON and Na‐ON:Im‐NO.
Citing Literature
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