Communication
Environment‐Sensitive Fluorescent Probe: A Benzophosphole Oxide with an Electron‐Donating Substituent*
*
This work was supported by JST, CREST (S.Y.), a Grant‐in‐Aid for Scientific Research on Innovative Areas “Organic Synthesis based on Reaction Integration” (no. 2105) from MEXT (Japan) (A.F.), and the Japan Advanced Plant Science Network. E.Y. thanks the JSPS for a Research Fellowship for Young Scientists. ITbM is supported by the World Premier International Research Center (WPI) Initiative, Japan.
Abstract
Electron‐donating aryl groups were attached to electron‐accepting benzophosphole skeletons. Among several derivatives thus prepared, one benzophosphole oxide was particularly interesting, as it retained high fluorescence quantum yields even in polar and protic solvents. This phosphole‐based compound exhibited a drastic color change of its fluorescence spectrum as a function of the solvent polarity, while the absorption spectra remained virtually unchanged. Capitalizing on these features, this phosphole‐based compound was used to stain adipocytes, in which the polarity of subcellular compartments could then be discriminated on the basis of the color change of the fluorescence emission.
Citing Literature
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