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ChemBioChem
Communication

Molecular Recognition of Watson–Crick‐Like Purine–Purine Base Pairs

Ragan Buckley

School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332‐0400 (USA)

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C. Denise Enekwa

School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332‐0400 (USA)

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Prof. Loren Dean Williams

School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332‐0400 (USA)

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Prof. Nicholas V. Hud

Corresponding Author

E-mail address:hud@gatech.edu

School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332‐0400 (USA)

School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332‐0400 (USA)
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First published: 29 July 2011
Cited by: 9

Abstract

Selection of a larger pair: Nucleic acid duplexes with non‐Watson–Crick base pairs are of interest to fields that span structural biology, supramolecular chemistry, origin of life, and synthetic biology. Here we demonstrate that intercalating molecules can exhibit selective binding of duplexes with purine–purine base pairs over duplexes with Watson–Crick base pairs, and vice versa.

Number of times cited: 9

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