Apparent diffusion coefficient is highly reproducible on preclinical imaging systems: Evidence from a seven‐center multivendor study
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Abstract
Purpose
To evaluate between‐site agreement of apparent diffusion coefficient (ADC) measurements in preclinical magnetic resonance imaging (MRI) systems.
Materials and Methods
A miniaturized thermally stable ice‐water phantom was devised. ADC (mean and interquartile range) was measured over several days, on 4.7T, 7T, and 9.4T Bruker, Agilent, and Magnex small‐animal MRI systems using a common protocol across seven sites. Day‐to‐day repeatability was expressed as percent variation of mean ADC between acquisitions. Cross‐site reproducibility was expressed as 1.96 × standard deviation of percent deviation of ADC values.
Results
ADC measurements were equivalent across all seven sites with a cross‐site ADC reproducibility of 6.3%. Mean day‐to‐day repeatability of ADC measurements was 2.3%, and no site was identified as presenting different measurements than others (analysis of variance [ANOVA] P = 0.02, post‐hoc test n.s.). Between‐slice ADC variability was negligible and similar between sites (P = 0.15). Mean within‐region‐of‐interest ADC variability was 5.5%, with one site presenting a significantly greater variation than the others (P = 0.0013).
Conclusion
Absolute ADC values in preclinical studies are comparable between sites and equipment, provided standardized protocols are employed. J. MAGN. RESON. IMAGING 2015;42:1759–1764.
Number of times cited according to CrossRef: 8
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