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Sleep and Biological Rhythms

Subjective effects of glycine ingestion before bedtime on sleep quality

Kentaro INAGAWA

Corresponding Author

Research Institute for Health Fundamentals, Ajinomoto Co., Inc., Kawasaki,

Dr Kentaro Inagawa, Research Institute for Health Fundamentals, Ajinomoto Co., Inc., 1‐1 Suzukicho, Kawasaki‐ku, Kasawaki‐shi 210‐8681, Japan. Email:

kentaro_inagawa@ajinomoto.com

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Takenori HIRAOKA

Health Service Development Department, Ajinomoto Co., Inc., Tokyo, and

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Tohru KOHDA

Health Service Development Department, Ajinomoto Co., Inc., Tokyo, and

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Wataru YAMADERA

Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan

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Michio TAKAHASHI

Research Institute for Health Fundamentals, Ajinomoto Co., Inc., Kawasaki,

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First published: 09 February 2006
Cited by: 3

Abstract

The effects of glycine on sleep quality were examined in a randomized double‐blinded cross‐over trial. The volunteers, with complaints about the quality of their sleep, ingested either glycine (3 g) or placebo before bedtime, and their subjective feeling in the following morning was evaluated with the St. Mary's Hospital Sleep Questionnaire and Space‐Aeromedicine Fatigue Checklist. The glycine ingestion significantly improved the following elements: “fatigue”, “liveliness and peppiness”, and “clear‐headedness”. These results suggest that glycine produced a good subjective feeling after awakening from sleep.

Number of times cited: 3

  • , Promotion of non–rapid eye movement sleep in mice after oral administration of ornithine, Sleep and Biological Rhythms, 10, 1, (38-45), (2011).
  • , Oral administration of glycine increases extracellular serotonin but not dopamine in the prefrontal cortex of rats, Psychiatry and Clinical Neurosciences, 65, 2, (142-149), (2011).
  • , Glycine ingestion improves subjective sleep quality in human volunteers, correlating with polysomnographic changes, Sleep and Biological Rhythms, 5, 2, (126-131), (2007).