Enantioselective Synthesis of 1,12‐Disubstituted [4]Helicenes

Abstract A highly enantioselective synthesis of 1,12‐disubstituted [4]carbohelicenes is reported. The key step for the developed synthetic route is a Au‐catalyzed intramolecular alkyne hydroarylation, which is achieved with good to excellent regio‐ and enantioselectivity by employing TADDOL‐derived (TADDOL=α,α,α,α‐tetraaryl‐1,3‐dioxolane‐4,5‐dimethanol) α‐cationic phosphonites as ancillary ligands. Moreover, an appropriate design of the substrate makes the assembly of [4]helicenes of different substitution patterns possible, thus demonstrating the synthetic utility of the method. The absolute stereochemistry of the newly prepared structures was determined by X‐ray crystallography and characterization of their photophysical properties is also reported.

Abstract: A highly enantioselective synthesis of 1,12-disubstituted [4]carbohelicenes is reported. The key step for the developed synthetic route is a Au-catalyzed intramolecular alkyne hydroarylation, which is achieved with good to excellent regio-and enantioselectivity by employing TADDOL-derived (TADDOL = a,a,a,a-tetraaryl-1,3-dioxolane-4,5-dimethanol) a-cationic phosphonites as ancillary ligands. Moreover, an appropriate design of the substrate makes the assembly of [4]helicenes of different substitution patterns possible, thus demonstrating the synthetic utility of the method. The absolute stereochemistry of the newly prepared structures was determined by X-ray crystallography and characterization of their photophysical properties is also reported.
Carbohelicenes are screw-shaped molecules formally derived from the ortho-condensation of benzene rings. [1] Even though no stereogenic centers are present in their structures, the twisted geometry imposed by their connectivity makes them chiral. The energetic barrier for the interconversion between the two enantiomeric forms is strongly dependent on the number of ortho-fused benzene units. The first member of the carbohelicene family with a helicoidal structure is [4]helicene, which is configurationally unstable under ambient conditions. [2] [5]helicene can be resolved, but the low activation energy of racemization (DG°= 24.1 kcal mol À1 ) does not hamper the slow interconversion of the enantiomers. Hence, the racemization of these structures is typically complete after a couple of days at room temperature. [3] The first configurationally stable member of the helicene family is [6]helicene. Racemization of [6]helicene only occurs after intensive heating (DG°= 36.2 kcal mol À1 ; t 1/2 (rac) = 48 min at 205 8C), making this scaffold the first carbohelicene intrinsically useful for the design of thermally stable chiral architectures. [4] Nevertheless, the absolute configuration of low-order [4] and [5]helicenes can be fixed either by installation of appropriate substituents at one or both termini of their fjord region, or by embedment of the helicene moiety into a more extended p-conjugated scaffold. [5] As an illustrative example, on the incorporation of a methyl substituent in the 1-position of [5]helicene, the enantiomerization barrier increases up to DG°= 39.1 kcal mol À1 , making 1-(methyl)- [5]helicene even more reluctant to racemize than [6]helicene. [6] The situation is analogous for [4]helicenes, but these structures require positions 1-and 12-to be simultaneously substituted to freeze the racemization process ( Figure 1). [7] Despite the impressive development already achieved in the synthesis of helicenes, [1] and the number of applications that configurationally stable low-order helicenes have found in diverse areas such as asymmetric catalysis, [8] chiral recognition, [9] or the design of molecular machines, [10] highly enantioselective syntheses of [5]carbohelicene derivatives are scarce. [11,12] To the best of our knowledge, no enantioselective route is available for the preparation of 1,12disubstituted [4]helicenes. [13] Being aware of the potential offered by Au-catalyzed hydroarylation reactions for the assembly of conveniently designed alkynes into polyarenes, [14] we conceived the enantiomeric synthesis of 1,12-disubstituted [4]helicenes from substrates of general formulae A or B (Figure 2).  TADDOL-derived a-cationic phosphonites recently developed in our laboratory were chosen as ancillary ligands for the preparation of the necessary Au precatalysts 2 because of their high modularity, which allows easy tuning of the chiral pocket around the Au atom; and their cationic character, ultimately responsible for the enhanced activity of the actual catalytic species if compared with other Au catalysts of similar structure but derived from neutral ligands. [15] We began our investigation by synthesizing dialkyne 3 a, which was obtained by Suzuki coupling between known bistriflate 4 and boronic acid 5 a (Scheme 1 a). [17] Subsequently, a complete array of Au precatalysts 2 a-g were screened for the successive double hydroarylation required to transform the model substrate into [4]helicene 1 a. Our initial explorative conditions were set up as follows: catalyst loading of 10 mol %, fluorobenzene as solvent, and a working temper-ature of À20 8C. All reactions were allowed to proceed for 96 hours or until total consumption of the starting material.
The performance of catalysts 2 a-c, all containing an acetonide backbone, was modest in terms of regio-and enantioselectivity (Table 1, Entries 1-3). Interestingly, replacement of the acetonide motif by methoxy groups, such as in Au complexes 2 d,e, improved the performance of the catalysts. [18] Specifically, catalyst 2 e, which contains four p-(CF 3 )Ph substituents, was able to promote the desired double cyclization towards [4]helicene 1 a with excellent enantio-(97 % ee) and regioselectivity (1 a:9 a; 98:2) ( Table 1, Entry 5). The catalytic system suffers, however, from low reactivity, and reaction times of up to four days were necessary.
In an attempt to solve this issue, the imidazolium moiety in ligand 2 e was exchanged by more-electron-withdrawing 1,2,3-triazolium units, and the already optimal chiral environment around the Au atom was maintained. Both resulting catalysts, 2 f and 2 g, were able to match, or even slightly overtake, the already outstanding regio-and enantioselectivities of 2 e (Table 1, Entries 6 and 7), and by employing 2 g the reaction times were shortened to only two days. No product derived from the 5-exo-dig cyclization of the substrate was observed in any of these experiments. A final solvent screening indicated that 2 g does not require the employment of fluorobenzene to maintain excellent levels of enantioinduction; highly competitive results were also obtained working in dichloromethane (Table 1, Entry 8). [15a] Finally, crystals of precatalyst 2 g were obtained, and its molecular connectivity was confirmed by X-ray diffraction (see Scheme 1 c and the Supporting Information).
The hydroarylation of substrates 8 a and 8 b towards non C 2 -symmetrically substituted 1 e proceeded in both cases with acceptable yields. The same major enantiomer was obtained from both reactions, albeit the enantioselectivity of the cyclization is slightly eroded when using 8 a as the substrate (Table 1, Entries 12 and 13). Considering that only one hydroarylation event is required to obtain 1 e from these substrates, it is not surprising that only 5 mol % of precatalyst 2 g is required for the reactions to conclude in 48 h. The X-ray structure of substrate 8 a and precursor 7 a are depicted in the Supporting Information.
Encouraged by these results, and seeking to further explore the viability of our cycloisomerization protocol towards other [4]helicene structures, additional alkyne precursors were evaluated. Thus, phenanthrene derivatives 18 a-j were prepared following a multistep route, which is described in detail in Scheme 2.
Key for the success of this synthetic plan was the effective preparation of phenanthrene intermediates 15 a-d by intramolecular hydroarylation of the corresponding alkynes. Although for substrates 13 a,b, containing a terminal alkyne, the cycloisomerization proceeded successfully in the presence of catalytic amounts of PtCl 2 , [19] neither PtCl 2 or Ph 3 PAuCl/ AgSbF 6 were able to satisfactorily promote the hydroarylation step for internal alkynes 14 c,d. Only the employment of Au precatalyst 19, containing a strong p-acceptor N-arylpyridinio phosphine as an ancillary ligand, induced the formation of 15 c,d in synthetically practical yields. [20] For substrates 18 a-c (R 2 = Me), the performance of 2 g (5 mol %) is mediocre in terms of regio-and enantioselectivity (Table 2, Entries 1-3), and significant amounts of undesired benzo[m]tetraphenes 21 a-c were obtained as side products. Interestingly, complete control over the enantioselectivity (97-99 % ee) is achieved by formal exchange of the methyl groups at position R 2 by phenyl groups (substrates 18 d-f); however, the regioselectivity of the cyclization for these substrates is still far from ideal (Table 2, Entries 4-6). Note that 8 a,b only differs from 18 d-f in a remote benzannulation, but this seems to be crucial to effectively direct the hydroarylation to the inner position of the phenanthrene (Table 1, . Similarly, alkynes 18 g,h only differs from 18 a,b in a phenyl substituent from the outer rim of the phenanthrene; however, for these structures the cyclization is again selectively directed to the desired position affording 20 g,h with high regioselectivity (Table 2, Entries 7-8). The best results of the series were obtained for substrates 18 i,j (R 1 = Ph, R 2 = OMe), which were transformed into 20 i,j with excellent regio-and enantioselectivities. Further scrutiny is ongoing to fully understand the effect of remote substitutions on the hydroarylation site, but it seems to be consistent that catalyst 2 g promotes higher enantioselectivites for p-extended structures. [15] The connectivity of parent [4]helicene 1 a was unambiguously confirmed by X-ray crystallography employing a racemic single crystal (Figure 3). In this compound the vertical distance between the overlapping C1 and C7 carbon atoms is 3.243(1) , which is basically identical to the value in [6]helicene (3.215 ). On the other hand, the torsion angles along the inner rim in 1 a (from C1 to C7, f = 20.3, 27.6, 27.6, 20.38) vary significantly if compared with those in [6]helicene (f = 11.2, 30.1, 31.0, 15.28), in particular for rings A and D. This difference is likely to be caused by the higher tolerance to geometrical distortion of the one-point-connected phenyl groups. [21] To examine the chiral stability of the [4]helicenes prepared, enantioenriched 1 a (98 % ee) was heated at 180 8C in 1,2-dichlorobenzene for 24 h and later monitored by chiral HPLC. No erosion of the ee value was observed, highlighting the configurational stability of 1,12-disubstituted [4]helicenes.
The absolute configuration of the newly prepared helicenes was determined to be P from the X-ray analyses of single crystals of 20 i and 20 j (See Figure 3 and the Supporting Information). [22] For 20 i, both the Flack and Hooft parameters (0.01(4) and 0.04(3), respectively) unambiguously support this assignment. For 20 j an identical conclusion can be reached (0.01 (12) and 0.09(5) for the Flack and Hooft parameters, respectively). The higher estimated standard deviation for the latter case is attributed to lower data redundancy for this measurement. Importantly, both independent results point to the same absolute configuration. Additionally, the circular dichroism spectra for [4]helicenes 1 a-e are shown in Figure 4. Comparison of these EDC spectra with that reported by Yamaguchi and co-workers for a 1,12-dimethyl substituted [4]helicene further confirms the assignment of the helicity made by crystallographic techniques. [23] The absorption and fluorescence spectra of the [4]helicenes synthesized can be found in the Supporting Information. Interestingly, compounds 1 a-e display blue fluorescence, with the emission maximum being located at 438-440 nm. The emission bands for 20 a-j, architectures characterized by only one benzannulation of the parent [4]helicene, are slightly blue-shifted and appear at 426-433 nm.
In summary, we report herein the first highly enantioselective synthesis of 1,12-disubstituted [4]carbohelicenes, achieved through the Au-catalyzed intramolecular hydroarylation of appropriate alkynes and employing a TADDOLderived a-cationic phosphinite as an ancillary ligand. Singlecrystal X-ray analysis unambiguously determined the connectivity of the new structures obtained and established their absolute configuration. Ongoing work in our laboratory is focused on the further optimization of the catalytic system developed towards the enantioselective synthesis of higherorder carbohelicenes and other polyhelical scaffolds.