Accelerated 3D T2w‐imaging of the prostate with 1‐millimeter isotropic resolution in less than 3 minutes

Purpose To achieve 3D T2w imaging of the prostate with 1‐mm isotropic resolution in less than 3 min. Methods We devised and implemented a 3D T2‐prepared multishot balanced steady state free precession (T2prep‐bSSFP) acquisition sequence with a variable density undersampled trajectory combined with a total variation regularized iterative SENSE (TV‐SENSE) reconstruction. Prospectively undersampled images of the prostate (acceleration factor R = 3) were acquired in 11 healthy subjects in an institutional review board‐approved study. Image quality metrics (subjective signal‐to‐noise ratio, contrast, sharpness, and overall prostate image quality) were evaluated by 2 radiologists. Scores of the proposed accelerated sequence were compared using the Wilcoxon signed‐rank and Kruskal‐Wallis non‐parametric tests to prostate images acquired using a fully sampled 3D T2prep‐bSSFP acquisition, and with clinical standard 2D and 3D turbo spin echo (TSE) T2w acquisitions. A P‐value < 0.05 was considered significant. Results The 3× accelerated 3D T2prep‐bSSFP images required a scan time (min:s) of 2:45, while the fully sampled 3D T2prep‐bSSFP and clinical standard 3D TSE images were acquired in 8:23 and 7:29, respectively. Image quality scores (contrast, sharpness, and overall prostate image quality) of the accelerated 3D T2prep‐bSSFP, fully sampled T2prep‐bSSFP, and clinical standard 3D TSE acquisitions along all 3 spatial dimensions were not significantly different (P > 0.05). Conclusion 3D T2w images of the prostate with 1‐mm isotropic resolution can be acquired in less than 3 min, with image quality that is comparable to a clinical standard 3D TSE sequence but only takes a third of the acquisition time.


| INTRODUCTION
Prostate cancer is the most common cancer in men. 1 In asymptomatic patients recommended for prostate cancer screening, elevated serum prostate specific antigen levels and/or an abnormal digital rectal examination leads to further imaging investigations, followed by invasive biopsy for histological confirmation. Whilst a screening program based on prostate specific antigen testing remains controversial, countries such as the United States offer asymptomatic men, who are 55-69 years, the opportunity to make an individualized decision regarding prostate specific antigen testing. 2 Imaging, in particular multiparametric MRI (mp-MRI) has redefined how patients with suspected cancer are managed. Mp-MRI offers the opportunity to detect and localize clinically significant prostate cancer. 3 It also contributes to locoregional staging, surgical and radiotherapy planning, [4][5][6][7] and the possibility to perform a targeted biopsy using either MRI-ultrasound fusion or direct in-bore guidance. A typical clinical mp-MRI protocol for prostate cancer detection consists of a 2D multislice T 2 -weighted (T 2 w) turbo spin echo (TSE) sequence, acquired in the transversal, sagittal, and coronal orientations, a 2D transversal multislice diffusionweighted single-shot echo-planar imaging sequence, and a dynamic contrast enhanced 3D T 1 -weighted spoiled gradient recalled sequence. 8 However, the lack of isovolumetric voxels in 2D acquisitions has limitations for image guided biopsy, in 3D localization and image fusion, and for surgical or radiotherapy planning and image-guided therapy.
True 3D imaging enables the visualization of the prostate in any arbitrarily angulated anatomical plane, without loss of image quality and can be acquired in reduced time as compared to separate multiplanar 2D acquisitions. [9][10][11][12] An isotropic high-resolution 3D T 2 w MRI with true volumetric coverage can potentially improve the sensitivity for cancer detection, enable more precise image-guided biopsy, and improve surgical planning or focal treatment. It can also be used to optimal benefit in emerging cutting-edge technologies such as simultaneous positron emission tomography (PET)/MR, wherein rapid true 3D T 2 w-MRI images can be provided for direct fusion with 3D PET. Other application areas include MRguided radiotherapy, on-board systems such as MR-LINACS (linear accelerators), and in radiotherapy planning, which require high resolution isotropic 3D images without any geometric distortion. However, conventional 3D T 2 w TSE imaging has been hampered by long acquisition times. These sequences are also highly susceptible to motion and blurring artifacts due to the long echo train sampling. Furthermore, the use of a series of 180° refocusing pulses at higher fields (3T and above) contributes to a high specific absorption rate (SAR).
Alternative techniques using T 2 -prepared gradient echo rather than spin echo sequences have been proposed to achieve faster 3D T 2 w imaging. 13,14 The high signal-to-noise ratio (SNR) efficiency of fully balanced steady state free precession (bSSFP) imaging sequences makes them a popular choice for various clinical applications, as previously demonstrated in both cardiac 15,16 and prostate T 2 -prepared MRI, 17 and also in combination with diffusion-prepared prostate imaging. 18 T 2 w-image contrast is achieved by performing segmented acquisitions interleaving the bSSFP readout with the desired magnetization preparation. 19,20 Recently, Cartesian trajectories with centric view ordering have been proposed for 3D segmented acquisitions mainly applied in paediatric and cardiac applications. [21][22][23] Advantages of a centric 3D Cartesian trajectory are that (1) no re-gridding steps are required, thus considerably simplifying the image reconstruction process, (2) the centric acquisition in the k y -k z plane enables immediate encoding of the magnetization prepared signal, and (3) less sensitivity to system imperfections (such as gradient delays, eddy currents, off-resonance errors, phase corrections) as compared to non-Cartesian acquisitions. The trajectory is also amenable to undersampling, wherein a variable density pattern is acquired using fewer shots, thus resulting in shorter scan times.
Here, we propose to combine a T 2 -prepared 19,20 multishot 3D bSSFP sequence with variable density undersampling and total variation regularized SENSE (TV-SENSE) reconstruction 24 to enable fast 3D isotropic T 2 w-imaging of the prostate in a clinically acceptable scan time. Our study involved detailed optimization of the sequence acquisition parameters, the variable density undersampling mask, and the TV-SENSE reconstruction to reduce the scan time, while enabling high SNR, image sharpness, and tissue contrast.

| Sequence/acquisition optimization
The T 2 prep-bSSFP signals depend on several intrinsic (tissue) and extrinsic (image acquisition) parameters. Therefore, image acquisition parameter values were optimized to achieve 3 main goals: (1) maximize signal intensity, (2) maximize contrast between any 2 different tissues (healthy and cancerous), and (3) maintain short scan times and insensitivity to T 1 recovery. A simulation framework based on the extended phase graph formalism 25 was implemented for this purpose. The T 2 prep-bSSFP sequence was then simulated in this framework, with variation of extrinsic and intrinsic parameter values. The extrinsic parameters optimized were the repetition time (TR), bSSFP flip angle (FA), and number of segments of the bSSFP readout (N seg ), for a range of intrinsic T 1 and T 2 relaxation parameters typically observed in healthy (T 2 = 150 ms) and cancerous (T 2 = 50 ms) prostate tissue. Variations in signal intensity and tissue contrast were simulated for the following combinations of the extrinsic | 723 VIDYA SHANKAR et Al.

| In vivo imaging
This study was approved by the local institutional review board. Following written informed consent, 11 healthy male subjects (n = 11; age = 26 ± 6 years) were scanned on a 3T PET-MR scanner (using only the MR-component of the Biograph mMR, Siemens Healthcare, Erlangen, Germany) using a body matrix/spine coil. MR measurements were obtained using the proposed prototype 3D segmented bSSFP readout preceded by a T 2 -preparation module 19,20 with duration of 90 ms and time between T 2 -preparation modules (shot-length = TR) of 1600 ms. The adiabatic T 2 -preparation module consists of 4 radiofrequency pulses in the sequence . Imaging parameters included: transversal plane, 304 × 304 × 60 matrix, 1 × 1 × 1 mm 3 resolution, FA = 57°, bSSFP TR/echo time (TE) = 4/2 ms, shot duration = 1600 ms, number of segments/shot N seg = 96, and 14 ramp-up pulses with linearly increasing FA to stabilize the readout magnetization.

| Image reconstruction
All undersampled T 2 prep-bSSFP datasets were reconstructed offline in MATLAB (Mathworks, Natick, MA) using the TV-SENSE reconstruction described in Cruz et al 24 and Lustig et al, 27 which involved minimizing the following cost function: where, I is the image to be reconstructed, E is the SENSE encoding operator that incorporates the coil sensitivities and the Fourier transformation, K is the 3× undersampled k-space, ∇ s is the first order finite difference operator, and λ S is the total variation regularization parameter. Data consistency is achieved using the l 2 norm, while the total variation operator is essentially the l 1 norm operating in the image domain. The value of λ S (2e −06 ) was empirically determined to achieve a good compromise between (1) image denoising and (2) (1) prevention of image blurring due to over-smoothing. The coil sensitivity maps for each dataset were generated using the ESPIRiT implementation from the BART MRI toolbox. 28

| Evaluation of image quality
The image quality of the accelerated T 2 prep-bSSFP images (along all 3 imaging planes: transversal, coronal, and sagittal) for each healthy volunteer was compared with the fully sampled reference T 2 prep-bSSFP and clinical standard multislice transversal 2D T 2 w TSE and 3D SPACE sequences by 2 experienced radiologists with more than 20 and 10 years of experience in MRI interpretation, respectively. Specifically, a subjective assessment of various metrics namely the SNR, contrast, image sharpness, presence of any artifacts from acquisition (including bSSFP banding) and the TV-SENSE reconstruction, and overall image quality in the whole prostate was conducted and scored on a (0-4) point scale, with the scoring criteria detailed in Table 2. Each of the above metrics was assigned a combined "agreed score" by the 2 readers.
The (mean ± standard deviation) scores were subsequently tabulated and compared using the Wilcoxon signed-rank and Kruskal-Wallis nonparametric tests to determine any statistically significant differences (P < 0.05) in image quality metrics between the 4 sequences under consideration.

| Sequence/acquisition optimization
Image acquisition parameters of the fully sampled and accelerated T 2 prep-bSSFP sequences were optimized to achieve the best balance between SNR, contrast-to-noise ratio (CNR), and a clinically feasible scan time for isotropic 1 mm 3 3D T 2 w imaging of the prostate with a T 2 prep TE of 90 ms. Figure 1A-C illustrates the intensity of the magnetization signal generated with the extended phase graph simulation framework for 2 different T 2 values as a function of FA, TR, and N seg , respectively. The 2 selected T 2 values (50 ms, 150 ms) represent the average reported values for cancerous and healthy tissue in the peripheral zone of the prostate at 3T. [29][30][31] As expected, signal intensity increases with increasing shotlength (TR) as it allows for more time or signal recovery; however, as a trade-off this will also increase the total acquisition time. Higher FA in the bSSFP readout yields higher SNR. However, due to SAR constraints, a maximum FA of 57° (for a chosen shot-length of 1600 ms) was achieved. Importantly, the contrast at a T 2 -prep duration of 90 ms was found to not change significantly over the simulated range of TR and FA values, as depicted in Figure 2A-C. It was also observed that increasing the number of segments per shot from 40 to 96 at a T 2 -prep duration of 90 ms did not cause a large drop in the signal (only 9.6% less signal, Figure 1C) or have an effect on the tissue contrast (only 0.7% less contrast, Figure 2C). But using more segments per shot (96 segments versus 40 segments) reduces the acquisition time by more than half, as fewer shots (spirals) are required to fill-up k-space. Guided by these observations, we were able to make the best compromise between the signal intensity, tissue contrast, and acquisition time for in vivo imaging, leading to the following set of optimal sequence parameters for the T 2 prep-bSSFP sequence: shot-length opt = 1600 ms, FA opt = 57°, N seg opt = 96. The corresponding scan time (min:s) with the optimal parameters for a fully sampled 1 mm 3 isotropic T 2 w dataset was 8:23, and with the ~3× accelerated T 2 prep-bSSFP sequence 2:45. In addition, the T 2 prep-bSSFP signal was verified in a volunteer dataset with the region of interest (ROI) positioned over the central gland of the prostate (Supporting Information Figure S1, which is available online) There is good agreement between the simulated (T 2 fix = 55 ms, T 1 fix = 2200 ms) and measured signal for T 2 Figure 3A shows the acquisition trajectory using Cartesian spirals (shots) that are centric in the k y -k z plane. The fully sampled and undersampled masks are depicted in Figure 3B and C, respectively. The center of k-space is fully sampled while the periphery is 4-fold undersampled, resulting in a net acceleration factor of 3×. To illustrate image quality, Figure 4 shows a single matched transversal slice for a representative healthy volunteer scanned using the multislice 2D T 2 w TSE, 3D SPACE, 3D fully sampled T 2 prep-bSSFP, and 3D accelerated T 2 prep-bSSFP sequences. It can be observed in Figure 4 (and Supporting Information Figure S2 showing additional subjects) that the accelerated 3D T 2 prep-bSSFP images have image quality that is comparable to the fully sampled 3D T 2 prep-bSSFP and clinical standard high resolution 2D T 2 w TSE images, and appear visually sharper than the 1 mm 3 isotropic 3D SPACE images. Figure 5 and Supporting Information Figure S3 illustrate a single matched transversal slice for 2 representative healthy subjects from the multislice 2D T 2 w TSE, 3D SPACE, 3D fully sampled and accelerated T 2 prep-bSSFP reconstructions, reformatted into the coronal and sagittal planes to facilitate comparisons in all 3 imaging orientations. The poor image quality of the coronal and sagittal reformats corresponding to the 2D T 2 w TSE can be attributed to the multislice 2D transversal acquisition and low resolution along the slice dimension (0.6 × 0.8 × 3 mm 3 ). The accelerated T 2 prep-bSSFP acquisitions appear to have no visually remaining artifacts from the TV-SENSE reconstruction along all the 3 dimensions, and display comparable image quality with the fully sampled T 2 prep-bSSFP and clinical standard TSE sequences. The normalized root mean square error between the fully sampled and 3× accelerated T 2 prep-bSSFP reconstructions for the volunteer group was (1.6 ± 0.46) %. The mean "apparent SNR" and normalized contrast comparisons (tissue/noise ROIs chosen are shown in Supporting Information Figure S4) between the sequences are shown in Supporting Information Table S1 and Supporting Information Table S2, respectively. The fully sampled and 3× accelerated T 2 prep-bSSFP images, which were full field of view (FOV) acquisitions with matched imaging parameters, show comparable "apparent SNR" and contrast for the whole prostate, muscle, and fat. the 3× accelerated T 2 prep-bSSFP images had very similar contrast (2.82 ± 0.41) and image sharpness (2.46 ± 0.69), with no statistically significant differences (P > 0.05) seen among any of the 4 sequences under consideration, but lower subjective SNR (2.27 ± 0.65; P < 0.05) as compared to the other 3 sequences. The multislice 2D T 2 w TSE images (with higher in-plane resolution 0.6 × 0.8 mm 2 and thicker slices of 3 mm) had the best overall image quality in the prostate in the transversal orientation, scoring better (P < 0.05) than the 3D T 2 prep-bSSFP images (with 1 mm 3 isotropic resolution). However, all three 3D sequences were found to be very comparable (P > 0.05) in terms of the overall image quality in the prostate.

| Evaluation of image quality
Similar scores and trends were observed for the accelerated T 2 prep-bSSFP reformats along the coronal and sagittal slices ( Figure 6). As expected, the 2D T 2 w-TSE was found to have non-diagnostic image quality metrics along the coronal and sagittal reformats due to the multislice acquisition and anisotropic image resolution of 0.6 × 0.8 × 3 mm 3 . In this study, it would not be fair to compare the reformats from the multislice 2D T 2 w-TSE with those from the true 3D acquisitions as the clinician would typically be evaluating the high resolution T 2 w images acquired individually along the coronal and sagittal orientations. The images from all three 3D sequences were found to have very similar (P > 0.05) image quality metrics along the coronal and sagittal orientations, as illustrated in Figure 6A-D. Some visually apparent banding and residual reconstruction artifacts (absent in the clinical 2D and 3D T 2 w-TSE sequences) were noted by the experts in the fully sampled and accelerated T 2 prep-bSSFP images for a few volunteers. However, these artifacts were external to the prostate and were found to not affect the diagnostic quality of the images.

| DISCUSSION
Our results show that 3D multishot T 2 prep-bSSFP acquisitions with variable density undersampling combined with TV-SENSE reconstruction enable rapid T 2 w imaging of the whole prostate with 1-mm isotropic spatial resolution in under 3 min at 3T. The accelerated T 2 prep-bSSFP images display similar image quality to the fully sampled T 2 prep-bSSFP and conventional clinical standard 2D/3D T 2 w TSE images, with the clear advantage of requiring only one-third the acquisition time. Our technique does not suffer from geometric distortion as it is gradient echo based, and is thus ideally suited for MR-guided radiotherapy and artificial intelligence (AI) applications that depend on high resolution data. Our approach is also suitable for fast 3D quantitative T 2 mapping 32 (that requires using multiple different T 2 -prep durations) with 1-mm isotropic resolution, which is currently not included in the clinical protocol for prostate mp-MRI due to the prohibitively long scan time.
Isotropic high resolution T 2 w imaging of entire anatomical structures in vivo with sufficient volumetric coverage still poses a challenge, mainly due to the long scan time and lack of sufficient SNR. Multiplanar, multislice 2D T 2 w TSE imaging along 3 orthogonal planes is the current gold standard in prostate imaging, requiring a total scan time of over 7-12 min to acquire all 3 orientations, each having a nonisotropic resolution of ~0.7 × 0.7 × 3 mm 3 . 11,33 True 3D T 2 w imaging, using a 3D TSE sequence such as the SPACE requires a scan time of over 7 min, as seen in our study and previously. 11 Importantly, SPACE is usually a zoomed (reduced FOV) acquisition, while our proposed approach offers the advantage of rapid full FOV imaging, which is a requirement in applications like radiotherapy planning. A full-FOV SPACE acquisition would require a prohibitively long scan time. Acceleration techniques like parallel imaging (R = 2) have been used to reduce the scan time (min:s) of the SPACE sequence to 3:52 for a resolution of 1 × 1.5 × 1.5 mm 3 with 2 averages, 34 which is still longer and has a lower spatial resolution than our proposed approach. The 3D SPACE images also tend to appear blurry due to motion and signal decay along the long echo train. Our approach using centric encoded T 2 -prepared 3D bSSFP imaging is not affected by blurring as the center of k-space is acquired at the beginning of the shot, and immediately after T 2 preparation. As each shot starts with acquiring data in a central region of k-space using a Cartesian "spiral-out" trajectory, motion will be averaged over multiple shots.
Rapid 3D T 2 w imaging in the prostate has been recently investigated using the T 2 -transition into driven equilibrium (T 2 -TIDE) and dual echo steady state (DESS) sequences. 13,14 A 3D T 2 -TIDE sequence was used by Srinivasan et al 14 for fast T 2 w imaging of the entire prostate in 2:54 at a spatial resolution of 0.9 × 0.8 × 1.5 mm 3 , F I G U R E 5 A comparison of different imaging planes from a representative healthy subject with 1-mm isotropic acquisition (T acq = acquisition time). A single matched transversal slice was reformatted into the sagittal and coronal planes for the multislice 2D T 2 w-TSE, 3D SPACE, fully sampled and accelerated 3D T 2 prep-bSSFP sequences. The coronal and sagittal reformats corresponding to the 2D T 2 w-TSE have poor image quality due to the multislice 2D transversal acquisition and 0.6 × 0.8 × 3 mm 3 resolution. The 3× accelerated T 2 prep-bSSFP images show comparable image quality particularly with the other 3D sequences in all 3 orientations with 2 averages and no additional acceleration methods. While this technique has comparable image quality to and is ~3× faster than the standard 3D TSE, the accelerated T 2 prep-bSSFP acquisitions achieve a higher spatial resolution along the slice dimension for the same acquisition duration. Dregely et al 13 used the DESS sequence for rapid 3D (1.1 × 1.1 × 3.5 mm 3 ) T 2 w prostate imaging using 1 average and no additional acceleration schemes in a scan time (min:s) of 1:03. In comparison, our accelerated T 2 prep-bSSFP acquisitions can achieve the same image resolution in 37 s.
Our approach required an optimization of the T 2 prep-bSSFP sequence parameters to achieve the best balance between the SNR, CNR, and scan time. A shot-length = 1600 ms and FA = 57° was chosen based on the results from our extended phase graph simulations, keeping in mind the long prostate T 1 recovery times and SAR considerations at 3T. In particular, the increased number of readout segments (N seg = 96), compared with the previously used 40 segments 17,35 translates in a decreased number of shots (Cartesian spirals) required to fill the k-space, and thus in a significant scan time reduction (58%) while maintaining a comparable SNR and CNR. The TV-SENSE reconstruction allowed the generation of artifact-free images of the 3× accelerated T 2 prep-bSSFP acquisitions, which were 4× undersampled in the peripheral k-space.
The accelerated T 2 prep-bSSFP images were perceived by the 2 readers to have comparable image quality to the fully sampled T 2 prep-bSSFP and clinical standard TSE sequences, particularly preserving high tissue contrast and image sharpness along all 3 dimensions. The T 2 contrast depends on the TE, TR, T 1 , and T 2 of the tissues under consideration, B 0 , and B 1 effects. In the 2D and 3D T 2 w TSE sequences, contribution from stimulated and indirect echoes in the multiecho signal affects the final T 2 contrast. We have previously evaluated the effect of B 1 /T 1 variations on the T 2 contrast of the T 2 prep-bSSFP sequence. 32 The Cartesian spiral-out acquisition in the k y -k z plane enables immediate encoding of the magnetization prepared signal, thus preserving the T 2 weighting. The 3× accelerated T 2 prep-bSSFP acquisitions did not suffer from loss in T 2 contrast as the center of k-space (25%) was fully sampled. The lower subjective SNR of the accelerated T 2 prep-bSSFP images was found to not limit the overall diagnostic quality of the whole prostate. In the cases where the fully sampled T 2 prep-bSSFP images scored lower than the F I G U R E 6 A qualitative/subjective evaluation of the image quality (A), SNR (B), tissue contrast (C), and image sharpness (D) in the overall prostate by 2 experienced readers. Results depict the combined "agreed score" assigned by the 2 readers for each image quality metric according to the scoring criteria listed in Table 2. The non-diagnostic outliers are from the multislice 2D T 2 w TSE reformats along the coronal and sagittal orientations. (*P < 0.05)
3× accelerated ones, the better performance of the accelerated sequence could potentially be attributed to the faster acquisition reducing the susceptibility to any motion artifacts, and the effect of additional de-noising from the TV-SENSE reconstruction.
In this study, the read-out was along the anterior-toposterior direction to reduce susceptibility to motion artifacts. Setting the read-out along the right-to-left direction can further reduce the acquisition time as the FOV in the right-to-left direction is ~2× the FOV in the anteriorto-posterior direction. However, acquisitions along the anterior-to-posterior direction are more prone to motion and might require additional motion compensation schemes. For example, 2D image navigators acquired during the bSSFP catalyzation period can be incorporated in the reconstruction for retrospective motion correction. Further acceleration could potentially be achieved using techniques like multidimensional parallel imaging, view sharing, and improved design of the k-space trajectory (e.g., a center oversampled trajectory to improve the SNR). However, there is a trade-off between acceleration and SNR with increasing sparsity, particularly in pure 3D high resolution isotropic imaging, which needs to be investigated.
Our study has several limitations. First, the undersampled data had to be reconstructed offline in Matlab TM using TV-SENSE, the time for reconstruction being ~20 min for each 3× undersampled 3D T 2 w dataset. Second, both the fully sampled and accelerated T 2 prep-bSSFP acquisitions are susceptible to banding artifacts arising from off-resonance effects. While artifacts were not observed over the prostate region in the healthy volunteers, slight banding was observed in the FOV in areas away from the ROIs in a few subjects. The standard shim was adopted for the healthy volunteer study following optimization of the protocol settings, and could require further optimization in patients. Our future approach would also involve using a gradient recalled echo readout to eliminate banding. Third, a true quantitative assessment of the SNR between the sequences under consideration was not feasible as there is no agreed method for SNR evaluation in the literature for regularized reconstructions. Finally, we have evaluated the feasibility of our accelerated T 2 prep-bSSFP acquisitions in a healthy volunteer cohort. Future studies would involve testing our proposed approach in prostate cancer patients to establish its utility over the current clinical standard TSE sequences.
Considering the above factors, clinically the proposed approach may be best suited to substitute at least one of the multiplanar 2D T 2 w TSE acquisitions, serving as a partial rather than absolute replacement for conventional multiplanar T 2 w imaging. The high-resolution isovolumetric images obtained in an acceptable time frame provide a better model for image-fusion co-registration, which is increasingly being used for biopsy and focal therapy in prostate MRI.

| CONCLUSIONS
In conclusion, we have demonstrated the feasibility of 3D T 2 w imaging in the prostate with 1-mm isotropic resolution in 2:45 min, by combining 3D multishot T 2 prep-bSSFP acquisitions with a variable density undersampled trajectory and TV-SENSE reconstruction. This facilitates high-resolution isotropic prostate imaging in a clinically acceptable scan time.

CONFLICTS OF INTEREST
Dr. Radhouene Neji is an employee of Siemens Healthcare Limited. Prof. Vicky Goh receives research support from Siemens Healthcare Limited.