Belief in safety and ethicality associated with willingness to undergo electroconvulsive therapy among employees of universities and the other research institution

Electroconvulsive therapy (ECT) is more effective and safer for severe major depressive disorder (MDD) than drug therapy, even though the pathophysiological mechanisms of ECT have not been elucidated. 1 – 3 During the modern era, ECT has been improving and has become more ethical 4 ; however, patients tend to avoid ECT because of their misconceptions. 5 Some people perceive ECT as a punishment based on their impressions gained from the media. 6,7 The ambivalent impressions about ECT generally held may deter treatment opportunities. 8 We identified the beliefs regarding ECT of people who have never experienced depression and the factors associated with these beliefs.

2][3] During the modern era, ECT has been improving and has become more ethical 4 ; however, patients tend to avoid ECT because of their misconceptions. 5Some people perceive ECT as a punishment based on their impressions gained from the media. 6,7The ambivalent impressions about ECT generally held may deter treatment opportunities. 8We identified the beliefs regarding ECT of people who have never experienced depression and the factors associated with these beliefs.
We conducted a cross-sectional study in multiple centers in 2008.
Attendees of an occupational mental health lecture conducted by A University, B Research Institute, and C University in Japan participated in this study.Before the lecture, a survey instrument on MDD (Supporting Information: Supplemental Materials 1) that was predesigned using the expert panel method was distributed to participants, and they answered the quizzes on the survey.The total number of correct answers served as the quiz score.A high score was considered scoring in approximately the top 50% of the responders on the 5-item quiz on ECT.Exclusion criteria were having possibility of personal identification, having a history of MDD or depressive mood, and incomplete questionnaires.We conducted a multivariable logistic regression analysis to assess the association between willingness to undergo ECT and other factors.To estimate the adjusted odds ratio (aOR) and 95% confidence intervals (CIs), willingness to undergo ECT was included as the binary dependent variable.The following items were included as independent binary or dummy variables: age; gender; occupation; a high quiz score on ECT knowledge; willingness to consult a psychiatrist or the other doctors and a clinical psycologist in the first help-seeking for MDD; and belief that ECT is efficacious, safe, and ethical.Analyses were performed using Stata 17.0 software (Stata Corporation).All tests of significance were two-tailed, and p-values < 0.05 were considered statistically significant.
Of the 320 (100%) participants listening to the lecture who agreed to participate in this study, 94 had incomplete questionnaires, seven did not respond to the quiz, one included information related to personal identification, and 60 had a history of MDD or depressive mood.The final analysis included 181 people (56.6%).Supporting Information: Supplementary Material 2 shows the demographic characteristics of the participants.Supporting Information: Supplemental Materials 3-1 and 3-2 show the distribution of the quiz scores.The cut-off score of five items was set to 3.
Willingness to undergo ECT was positively associated with the belief that ECT is safe and ethical.From the point of safety, no difference between drug therapy and ECT existed in serious medical events. 9Regarding ethicality, many people had a negative impression of the ethicality of ECT considering its history.For example, staff had used it occasionally to punish patients in psychiatric wards. 10At present, all patients who need ECT should receive enough information by psychiatrists, rather than being influenced by the media.
The variables "High quiz score on ECT's knowledge" and "The belief that ECT is efficacious" were not associated with willingness to undergo ECT in the results after adjustment.Specifically, both variables were significant, which led to the addition of the variable "The belief that ECT is ethical.""The belief that ECT is ethical" confounds the relationship between "Willingness to undergo ECT" and "The belief that ECT is efficacious."However, thoughts about ECT seem to be stigmatized regarding its ethicality.In future, we should clarify stigma toward the treatment of mental illness.
This study has some limitations.First, agreement to ECT might have improved since this research period based on a Recommendation in 2013 (https://journal.jspn.or.jp/jspn/openpdf/1150060586.pdf).Second, we did not validate the questionnaires and the quiz.
Improving the safety and ethicality of ECT and mitigating the barriers to psychiatric treatment might lead to better acceptance of ECT.Note: Values are expressed in terms of frequency (percentage).All factors were adjusted after conducting multivariate logistic regression analysis, such that each factor indicates an independent value for the adjusted odds ratio.

T A B L E 1
Factors associated with willingness to undergo ECT