Treatment patterns of systemic drug use in Japanese patients with plaque psoriasis: A retrospective chart review

Plaque psoriasis (PsO) is a chronic immune‐mediated inflammatory disease with skin lesions accompanied by an inflammation‐related comorbidity risk. The development of various oral drugs and biologics for PsO has provided increasing systemic treatment options for patients with PsO, and the guidance regarding the use of biologics and PsO treatment schemes are widespread in Japan. However, no comprehensive guidelines regarding systemic drug use are available, and the current treatment patterns of systemic drugs for PsO in Japan remain unclear. We conducted a retrospective chart review to clarify the current treatment patterns of systemic drugs for PsO. We enrolled 114 patients who started systemic drugs for PsO between January 2017 and December 2020 at four institutes, with a mean follow‐up of 37.2 months. The mean disease duration was 7.8 (standard deviation 9.5) years at the systemic drug initiation. Of all the patients, 78.1% started with oral drugs (phosphodiesterase [PDE] 4 inhibitors 56.1%. calcineurin inhibitors 14.0%. vitamin A derivatives 7.9%), whereas 21.9% started with biologics (interleukin [IL]‐17 inhibitors 9.6%. tumor necrosis factor inhibitors 7.0%. IL‐23 inhibitors 3.5%. IL‐12/23 inhibitors 1.8%). Oral drugs had shorter drug persistence than biologics: the 12‐month persistence of the oral drugs vitamin A derivative, calcineurin inhibitor, and PDE4 inhibitor, was 35.5%, 25.8%, and 60.1%, respectively, compared with that of the biologics IL‐23 and IL‐17 inhibitors, which was 85.6% and 84.7%, respectively. During the study period, the incidence of treatment changes was 59.1/100 patient‐years. Lack of efficacy was the most common reason for treatment changes from monotherapy (34.1%). This retrospective medical chart review allowed us to understand the real‐world, long‐term treatment patterns of systemic drugs for PsO and the relationships between the reasons for treatment changes and subsequent treatment selection, indicating that there is still room for improvement in the appropriate use of systemic drugs for PsO in Japan.

It is unclear whether PsO triggers multiple comorbidities or vice versa, but chronic systemic inflammation negatively affects PsO severity and increases cardiovascular risk.Aside from lesions on the body, PsO is associated with multiple comorbidities, such as atherosclerosis and cardiovascular disease, 5 including myocardial infarction and stroke, 6,7 metabolic syndrome, hypertension, type 2 diabetes mellitus, and dyslipidemia. 8,9Some evidence suggests that tumor necrosis factor (TNF) inhibitors and interleukin (IL)-17 inhibitors reduce cardiovascular risk in patients with PsO. 10 More importantly, it has been reported that approximately 20% of patients with PsO develop psoriatic arthritis with irreversible joint destruction. 11Reportedly, patients receiving IL-12/23 or IL-23 inhibitors have a lower risk of developing inflammatory arthritis than those prescribed TNF inhibitors, 12 therefore appropriate long-term treatments for PsO are required to control systemic inflammation.
As of December 2020, four types of oral drugs, including phosphodiesterase 4 (PDE4) inhibitors, antifolates, calcineurin inhibitors, vitamin A derivatives, and 11 biologics, had been authorized in Japan as systemic drugs for PsO.[15] The treatment scheme for Japanese patients with PsO based on the PsO treatment pyramid plan 16 has reached a consensus, and the Japanese Dermatological Association (JDA) has released guidance regarding the use of biologics and Janus kinase inhibitors for PsO 17,18 ; however, there are no comprehensive guidelines regarding systemic drug use for PsO. 13,14The selection of systemic drugs for each patient among various types of oral drugs or biologics therefore depends on the physician's judgment and patient preference.In addition, the long-term treatment courses for PsO can vary among Japanese patients.As patients with PsO are likely to undergo lifelong treatment, the treatment selection for each patient can also affect healthcare costs.
0][21] PsO is a chronic disease requiring long-term treatment for several years.Therefore, further investigations to clarify the longer-term systemic treatment courses and outcomes for PsO are needed to continuously provide appropriate systemic drugs for patients with PsO who may require lifelong treatment.Furthermore, systemic treatment options for PsO are expanding.After this study period, a TNF-α inhibitor, an IL-17 inhibitor, and a tyrosine kinase 2 inhibitor were approved in Japan. 14,22,23Therefore, understanding the correct administration of drugs tailored to each patient's needs is increasingly crucial.
This study aimed to investigate the long-term treatment course, patterns of treatment change for each systemic drug (e.g., drug interruption and switching to other treatments), reasons for treatment change, and the relationship between the reasons for treatment change and subsequent treatment by analyzing the medical records of patients with PsO for at least 2 years.

| Study design and data sources
This multicenter, non-interventional, retrospective observational study was conducted at four JDA-certified medical institutions in Japan between January 1, 2017, and December 31, 2020.All four institutes were tertiary medical institutions authorized to dispense biologics to patients with PsO.We aimed to collect data from 120 patients, based on existing research. 24Data of patients with PsO were collected from medical records using electronic data capture systems.All patients who started a systemic drug for PsO on or after January 1, 2017, at the four tertiary medical institutions and who met the eligibility criteria were enrolled in this study.Treatment courses with systemic drugs for PsO and the reasons for treatment changes, including switching to other systemic drugs, addition of other drugs, and treatment interruption, in clinical settings were collected retrospectively.All data were anonymized prior to analysis.The ethical review boards of the institutions involved in this study approved the study protocol and waived the requirement for informed consent because the study design was non-experimental and retrospective.This study was conducted in accordance with the International Society for Pharmacoepidemiology Guidelines for Good Pharmacoepidemiology Practices and applicable regulatory requirements.This study was registered at Clini calTr ials.gov under the identification number NCT04826536.

| Inclusion and exclusion criteria
Eligible patients were defined as those who were aged ≥20 years and had a diagnosis of PsO at the start of follow-up, had initiated a systemic drug such as TNF-α inhibitors (infliximab, adalimumab, and certolizumab pegol), IL-12/23 inhibitors (ustekinumab), IL-23 inhibitors (guselkumab, risankizumab, and tildrakizumab), IL-17 inhibitors (secukinumab, ixekizumab, and brodalumab), PDE4 inhibitors (apremilast), antifolates (methotrexate), calcineurin inhibitors (cyclosporine), or vitamin A derivatives (etretinate) during the study period and had been followed up for at least 2 years after the initiation of systemic treatment.Patients were excluded if they participated in another clinical trial for PsO before or during the study period, if they had psoriatic arthritis, guttate psoriasis, erythrodermic psoriasis, or pustular psoriasis at the start of follow-up, and if they had already received any systemic drugs investigated in this study before the diagnosis of PsO.

| Data collection, definition of treatment change, and other variables of interest
Demographics and patient background characteristics, including age, sex, duration of PsO, and comorbidities, were collected for all patients at the start of the follow-up.Based on the medical records at the time of each hospital visit, the treatment courses of systemic drugs for PsO were collected during the study period, including prescribed drug names and their categories, and reasons for treatment changes, to clarify the persistence of systemic drug use and patterns of treatment changes.In addition, data on concomitant phototherapy (ultraviolet B [UVB], psoralen ultraviolet A [PUVA]) was also collected.Treatment changes were categorized into six types: switching to another systemic drug, adding another drug, reducing a drug from multidrug therapy, treatment interruption, starting systemic drug after interruption, and restarting the previous systemic drug after interruption.Switching to another drug, adding another drug, and reducing a drug from multidrug therapy were counted as a case if the treatment change occurred on the visit day scheduled for a prescription.The interruption was counted as a case if the patient did not receive the prescription on the visit day scheduled for the prescription or if the patient did not visit the medical institution for the prescription within 28 days after the scheduled prescription date.Additionally, the number of interruptions and the reasons were counted by the definition of the interruption period of ≥28, ≥60, ≥90, and ≥ 180 days.The treatment duration was defined from the start of systemic drug or treatment change to the day immediately before the next treatment change or to the end of follow-up.The reasons for treatment changes were categorized into five types: occurrence of a new type of PsO (e.g., psoriatic arthritis, guttate psoriasis, erythrodermic psoriasis, and pustular psoriasis), adverse events (AEs), lack of efficacy, sufficient efficacy, and others.All data regarding treatment changes and the reasons for treatment change were linked to the systemic drugs prescribed until the time of treatment change.
Psoriasis Area and Severity Index (PASI) scores were calculated to measure the severity and extent of the PsO lesions. 25The frequency of treatment change per 100 patient-years was calculated as the number of treatment changes divided by the corresponding patientyears of observation.

| Statistical analysis
Patient characteristics for each systemic drug started during this study were analyzed using descriptive statistics (mean, standard deviation [SD]).Frequencies and proportions (%) were calculated for categorical or ordinal variables.The Kaplan-Meier method was used to estimate the persistence of initial systemic drugs during the study and all systemic drugs during the study period based on the number of events and censored data.Statistical analyses were performed using SAS software version 9.4 (SAS Institute Inc., Cary, NC, USA).

| Study population and the initial systemic drug
The study population consisted of 114 patients, 69.3% were men, and the mean (SD) age was 52.6 (16.3) years (Table 1).The mean (SD) duration from the first diagnosis for PsO to the start of systemic drug use was 7.8 (9.5) years, and systemic treatment courses were followed up for a mean period of 37.2 months.Among the study population, 78.1% started with oral drugs (PDE4 inhibitors 56.1%, calcineurin inhibitors 14.0%, vitamin A derivatives 7.9%) as the initial systemic drug, whereas the remaining 21.9% started with biologics (IL-17 inhibitors 9.6%, TNF inhibitors 7.0%, IL-23 inhibitors 3.5%, IL-12/23 inhibitors 1.8%) (Table 1).All patient populations for each initial systemic drug had comparable PsO durations and follow-up periods.The mean (SD) PASI score at baseline was 12.7 (8.9), and 51.4% (19/37) of patients had PASI ≥10.Patients who had started TNF-inhibitors, IL-17 inhibitors, or vitamin A derivatives during the study tended to have a higher mean PASI score (18.7, 18.5, and 18.8, respectively), whereas those who had received PDE4 inhibitors or calcineurin inhibitors tended to have a lower mean PASI score (11.0 and 6.9, respectively).Comorbidities were observed in 69.3% of the study population, and the most common comorbidity was dyslipidemia (20.2%), followed by hypertension (19.3%) and diabetes mellitus (15.8%).There was no clear trend between comorbidities and the initial systemic drugs started during the study (Supporting Information Table S1).
Following the second systemic drug, 28 patients (24.6%) switched to a third systemic drug, and the tendency of selecting a third systemic drug was almost similar to that of selecting the second, although the percentage of calcineurin inhibitors selected as a third systemic drug increased slightly.Furthermore, the fourth systemic drugs were administered to 16 patients (14.0%).Treatment changes of all patients who started systemic drugs during the study are shown in swimmer plots in Supporting Information Figure S1a-g.
Among the initial systemic drugs started during the study (used by more than 10 patients), the persistence of IL-17 inhibitors was the longest; 90.9% of patients continued to use them for 18 months (Figure 1a).The persistence of PDE4 inhibitors decreased to 68.5% at 12 months and then decreased gradually to 59.5% at 30 months.The persistence of calcineurin inhibitors decreased to 41.4% at 12 months.Among all systemic drugs followed up during the study period, IL-23 and IL-17 inhibitors had the longest 12-month persistence (85.6% and 84.7%, respectively) (Figure 1b).The persistence of TNF and PDE4 inhibitors decreased to 66.3% and 60.1%, respectively, in 12 months.The 12-month persistence of vitamin A derivatives and calcineurin inhibitors was relatively short at 35.5% and 25.8%, respectively (Figure 1b).

| Patterns of treatment changes and the reasons
Among 114 patients with PsO, there were 209 treatment changes during the study period (Table 3), and the incidence of treatment change was 59.The median interruption period was approximately 3 months (Figure 2).To determine the extent to which the total number of interruptions and the reasons varied by the duration of the interruption period, when the interruption period was defined as ≥28, ≥60, ≥90, and ≥180 days after ceasing treatment with systemic drugs, the total number of interruptions and the reasons were counted (Table 5).Overall, the total number of interruptions decreased gradually as the definition of interruption period was extended.In contrast, patients receiving biologics and calcineurin inhibitors did not receive concomitant phototherapy (Table 6).

| Study population and the initial systemic drug
This study aimed to understand real-world, long-term PsO treatment patterns, reasons for treatment changes, and relationships between the reasons for treatment change and subsequent treatment.
TA B L E 2 Proportion of treatment changes and subsequent systemic drugs.

We retrospectively reviewed the medical charts of 114 patients with
PsO who started systemic treatment at four Japanese medical institutes between January 2017 and December 2020.We followed their systemic treatment courses, including up to the seven drug changes, during a mean follow-up period of 37.2 months.
This study clarified that Japanese patients with PsO started a systemic drug after a mean period of 7.8 years following the first PsO diagnosis.In contrast, a retrospective database research study in the USA reported that patients with PsO started systemic treatment within 2 years of PsO diagnosis. 26Although there are many differences in the healthcare system between Japan and the USA, this may be because of limited access to JDA-certified medical institutions in charge of prescribing biologics to patients with PsO.As of April 2023, 870 JDA-certified medical institutions have dispensed

IL-23i IL-17i PDE4i
TNFi Vit A deriv biologics to patients with PsO in Japan; however, these institutions were particularly insufficient in rural areas. 27Improving access to biologics for PsO can lead to the early provision of appropriate systemic treatment for Japanese patients, particularly those unsatisfied with existing topical and conventional systemic treatments.
Apremilast is a PDE4 inhibitor approved in Japan in December 2016 for treating adult patients with moderate-to-severe PsO.The percentage of Japanese patients with PsO who were treated with PDE4 inhibitors increased dramatically during the period between 2016 and 2018, which partially overlapped with the study period. 28r study also demonstrated that PDE4 inhibitors were used most frequently (56.1%) in patients who started a systemic drug between 2017 and 2020.In contrast, 21.9% of patients started with biologics during the study, nearly twice the proportion of patients treated with biologics in a previous study using the Japan Medical Data Center (JMDC) database. 20However, the proportion of patients undergoing treatment with PDE4 inhibitors in this and the JMDC study was comparable.This study was conducted in JDA-certified medical institutions, where many patients with moderate-to-severe PsO seek medical care and are prescribed biologics, which may explain the present results.The JDA guidance 17 states that biologics should be reserved for (1) patients with skin lesions extending over ≥10% of the body surface and who have not responded adequately to existing systemic therapies, including phototherapy, or (2) patients with hardto-treat skin lesions or joint symptoms that persist despite existing treatments and whose quality of life is severely impaired.The mean PASI score of patients who started biologics during the study was higher than that of patients starting PDE4 inhibitors during the study.This indicates that patients with more severe diseases tend to start treatment with biologics, as specified in the JDA 17 Although we focused on how can impact drug selection, we did not observe any clear trend comorbidities and initial drugs during the study.

| of treatment changes and persistence
More than of the patients who started a systemic drug during the study switched to another systemic drug.Approximately half of the patients who switched to a second systemic drug switched to a third systemic drug, and roughly half of them switched to a fourth systemic drug.Similarly, high frequencies of treatment changes were reported in a previous publication. 20Furthermore, these findings may reflect the actual clinical practice in Japan, where patients with moderate-to-severe PsO have difficulty receiving appropriate systemic drugs.Of the patients who switched to second or subsequent systemic drugs, approximately half selected biologics, and approximately one-fourth selected PDE4 inhibitors.Thus, biologics and PDE4 inhibitors were commonly used as drug alternatives among patients unsatisfied with their ongoing systemic drugs.
In this study, oral drugs tended to have shorter persistence than biologics such as IL-17 and IL-23 inhibitors, although PDE4 inhibitors showed relatively longer persistence in oral drugs.Japanese patients with PsO prefer oral to injectable drugs as systemic treatment, 29 and clinical challenges remain for long-term treatment with oral drugs.The drug persistence of biologics and oral drugs was comparable with that reported in our previous 1-year retrospective study. 20e treatment duration for each oral systemic drug in this study extended approximately two-to three-fold that of our previous study, 20 probably because of the extended follow-up period in study.This study clarified the real-world, long-term systemic treatment courses and the tendency of treatment changes in Japanese patients with PsO.

| Patterns of treatment changes and the reasons
Interruption of systemic drugs was observed frequently, consistent with a previous retrospective database study. 19However, the proportion of interruptions in this study was lower than that in the previous study. 19As the definition of interruption period was extended to ≥60, ≥90, or ≥180 days after ceasing systemic drugs, the number of total interruptions gradually decreased.Many patients who in-  reasons may also include poor drug adherence or financial reasons.
In such cases, the majority of patients restarted any systemic drug within 3-6 months.
Patients with PsO experience significant treatment burdens, including healthcare costs, time costs, and physical burdens (e.g., injection frequency). 30,31In particular, the cost of biologics may discourage patients from starting treatment with biologics as an initial treatment.However, frequent treatment changes, including the use of biologics, can lead to an increase in healthcare costs comparable to the costs of long-term use of biologics. 32Moreover, improper treatment interruption can lead to the exacerbation of PsO and increased risk of comorbidities, including psoriatic arthritis.Providing continuous and appropriate treatment to patients with chronic PsO is crucial.Lack of efficacy was the most common reason for switching from monotherapy, followed by AEs.
Although the reasons for adding other drugs were not analyzed in this study, it is plausible to assume that it was due to the inefficacy of the original drug.This suggests that approximately half of the treatment changes from monotherapy were due to a lack of efficacy.Treatment changes from oral drugs were more frequent than those from biologics, and lack of efficacy was a more common reason for oral drugs than biologics.These results suggest that there is still room for improvement in the appropriate use of systemic drugs for PsO in Japan.

| Concomitant use of phototherapy
Phototherapy was performed sporadically during the study period and was used as a supportive treatment for PsO.A recent study showed that phototherapy combined with a PDE4 inhibitor could enhance treatment efficacy without impacting safety. 33Our results may reflect the acceptance of phototherapy combined with a PDE4 inhibitor as one of the treatment options in Japan.

| Limitations
This study had several limitations.First, data regarding the PASI Finally, given the small sample size and that the four participating institutes were tertiary institutions, the patient population in this study may not fully reflect that of general medical institutions in Japan.Nevertheless, the institutions were representative tertiary hospitals of medical universities in Japan, and play an important role in community medicine in each region of the country.Medical chart reviews can be the best source for understanding the current state of disease treatment and clinical outcomes.This retrospective chart review provides real-world data regarding the systemic treatment of PsO in Japanese patients in a hospital setting.

| CON CLUS ION
Japanese patients with moderate-to-severe PsO started systemic treatment after a mean period of 7.8 years following the first diagnosis, reflecting the insufficient availability of systemic treatment for patients with chronic PsO in Japan.Most patients started with oral drugs as their first option, but in many cases these drugs were less effective, leading to more frequent changes in treatment.Our study suggests that it is desirable to have oral drugs with longerlasting, higher efficacy for moderate-to-severe cases of psoriasis.
Biologics were used in a limited number of patients with relatively higher severity of PsO and patients who interrupted oral drugs due to lack of efficacy.Biologics had relatively higher persistence than oral drugs, but a certain number of patients treated with biologics changed treatment because of AEs or other reasons.As more systemic treatment options become available for PsO treatment, using each drug properly will be even more crucial.We believe that our research has shed light on each existing drug's usage patterns, contributing to the optimization of future psoriasis treatment.

2 )
Abbreviations: CaN, calcineurin; i, inhibitors; IL, interleukin; PASI, Psoriasis Area and Severity Index; PDE4, phosphodiesterase 4; SD, standard deviation; TNF, tumor necrosis factor; Vit A deriv, vitamin A derivatives.aFrom the date of diagnosis of psoriasis to the start of follow-up.bTheduration of psoriasis was calculated with n = 113 for all, and n = 8 for those receiving vitamin A derivatives.

TA B L E 3 9 )
Abbreviations: CaN, calcineurin; i, inhibitors; IL, interleukin; PDE4, phosphodiesterase 4; TNF, tumor necrosis factor; Vit A deriv, vitamin A derivatives.a Multidrug therapy due to the addition of another drug.
terrupted systemic drugs tended to restart any systemic treatment within 6 months after interruption, regardless of the reasons.Other TA B L E 5 Number of interruptions, their reasons, and duration.
scores were limited owing to the retrospective study design, and we could not assess detailed patterns of treatment changes by PsO severity.Second, the clinical outcomes for each patient who underwent various treatment changes could not be evaluated because of limited information regarding the severity and disease condition at the end of the follow-up.Third, some biologics-in particular anti-IL-23p19 agents-were approved in Japan during the study period, such as guselkumab (March 2018), risankizumab (March 2019), certolizumab pegol (December 2019), and tildrakizumab (June 2020), therefore the proportion of patients treated with these agents might be underestimated.Fourth, because the number of patients receiving each agent was limited, it was not possible to analyze the effect of patient background on persistence with each agent.
Persistence of systemic treatment (drug survival).Kaplan-Meier survival analysis to analyze curves for drug survival persistence analysis.(a) Persistence of initial systemic drugs started during the study (in more than 10 patients) and (b) persistence of all systemic drugs followed up during the study period (in more than 10 patients).The number of patients at risk for each systemic drug is shown below the time point of the x axis.
E 1 Concomitant use of phototherapy.
Abbreviations: CaN, calcineurin; i, inhibitors; IL, interleukin; PDE4, phosphodiesterase 4; PUVA, psoralen ultraviolet; TNF, tumor necrosis factor; UVB, ultraviolet B; Vit A deriv, vitamin A derivatives.a Cases that were duplicated were considered.When multidrug therapy was combined with phototherapy, the number of times phototherapy was used concurrently with each drug was counted.