Reducing variation in hospital mortality for alcohol‐related liver disease in North West England

Variations in emergency care quality for alcohol‐related liver disease (ARLD) have been highlighted.


| INTRODUC TI ON
Alcohol-related liver disease (ARLD) typically presents late and often with fatal complications. In the UK it is estimated that up to 75% of fatal liver cirrhosis is undetected before a patient's first hospitalisation. 1,2 Nevertheless, early inpatient intervention with evidence-based treatments has the potential to save lives. 3 However, variation in the provision, quality and consistency of inpatient care has been highlighted in several countries. In the UK in 2013, a report entitled "Measuring the Units" from the National Confidential Enquiry into Patient Outcome and Death (NCEPOD) showed suboptimal care for patients dying during a hospitalisation for ARLD. 4 Only 47% of cases were judged to have received "good care" in hospital and potentially avoidable deaths were identified. A year later, the Lancet Commission highlighted wide variation in inpatient mortality, describing a "postcode lottery of liver services" 2 and a parliamentary group raised "grave concerns" about patchy provision of high-quality specialist care. 5 A follow-up report included a comparative analysis of administrative data for in-hospital mortality for non-elective admissions for "liver disease" across 134 English hospitals (2014-2018), suggesting more than twofold variation both in crude mortality (range: 6%-16%) and standardised mortality ratio (SMR ranging from approximately 60-140) across providers. 6 Specific data for ARLD were not presented. Evidence of inconsistent acute care for patients admitted to US hospitals with decompensated liver disease were reported in 2012 7 and 2014. 8 There has been progress in defining candidate process measures to help identify variations in key aspects of care and support quality improvement (QI). [9][10][11][12] However, no real-world evidence has emerged for QI programmes leading to reductions in avoidable hospital mortality. In 2016, Dyson et al reported an initiative for decompensated cirrhosis from three English hospitals. 13 Responding to NCEPOD recommendations, the authors introduced a "liver bundle" to promote best practice and undertook audits of care before and after efforts to implement it. Alcohol was the underlying cause of cirrhosis in 85% of cases. After roll-out, the bundle was completed in 59% of 136 patients and these cases had significantly higher rates of early diagnostic ascitic tap, antibiotic prescribing and documentation of alcohol consumption. Overall mortality was 15%, but the study was unable to detect significant reduction in death rate over time, nor demonstrate a lower rate of mortality for patients with a completed bundle.
An editorial expressed frustration that despite a successful effort to implement a policy promoting early delivery of evidence-based care, evidence for improvement in the "hard end-point" of survival was lacking. 14 The commentary suggested that future evaluations of QI interventions needed to include centres where in-hospital mortality was "unusually high." The North West region of England has one of the country's highest rates of alcohol-specific deaths and ARLD is the dominant cause. 15 In early 2015, the Advancing Quality Alliance launched a regional QI programme focused on improving emergency hospital care for ARLD. We report a retrospective analysis of time trends in inpatient mortality across seven participating hospitals, using independent administrative data to examine whether the programme was associated with a reduction in unwarranted variation in deaths during emergency admission for ARLD. This work was part of the North West Coast Connected Health Cities programme, a publicly funded regional health informatics initiative aimed at enhancing analysis of routine healthcare data to support establishment of learning healthcare systems. 16

| Study design
This was a retrospective observational cohort study using routinely collected, anonymised administrative data for the period 2014/2015 to 2017/2018.

| Setting
Seven acute hospitals in the North West region of England that participated in a regional QI programme.

| The Advancing Quality intervention
Advancing Quality (AQ) is a care programme operated by the Advancing Quality Alliance (AQuA) which delivers a range of services to NHS healthcare organisations across the North West of England. 17 The programme offers members a structured approach to embedding evidence-based care with the aims of improving health outcomes while reducing unwarranted variation in the care of highly prevalent conditions. Prior to launch of each programme, a local Clinical Expert Group reviews evidence and identifies a set of condition-specific interventions known to improve outcomes along with a set of process measures to allow benchmarking of care ("AQ measures"). The AQ programme includes continuous audit of samples of admissions to monitor hospital-level performance against AQ measures, with transparent monthly reporting and a series of regional QI meetings of participating teams. The QI initiative was also supported by an optional financial incentive scheme (Commissioning for Quality & Innovation, CQIN) during 2015/2016 to 2016/2017, whereby local service commissioners could assign a small proportion of contracted payments to acute hospitals for participation. 18 The programme for ARLD was launched in 2015, with an original set of 11 AQ measures collected. 19 The measures focused on the early detection and management of complications linked to in-hospital mortality (eg spontaneous bacterial peritonitis and variceal bleeding) as well as triage to correct ward and early specialist hepatology input ( Table 5). Review of AQ measures by the Clinical Expert Group in 2017/2018 resulted in refinement of some definitions, merger or retirement of selected process measures (to simplify data collection or remove metrics that were no longer required), resulting in seven process metrics.

| Data sources, information governance and ethics
Complete administrative data were available for seven participating hospitals for the period 2013/2014 to 2017/2018. The dataset is equivalent to Hospital Episode Statistics, as previously described. 20 We focused our analysis on admissions in the year before the AQ programme was launched (2014/2015) and three consecutive fiscal years after the intervention (2015/2016 to 2017/2018). Data for 2013/2014 were used as screening period to enable identification of index ("first") admissions for ARLD (see cohort selection below).
This work formed part of a service evaluation and improvement programme and made use of anonymised administrative data with approval from NHS Digital, hence ethical approval was not required.
Benchmarking reports based on our analyses of administrative data were shared with hospital teams in August 2019.
Aggregated hospital-level information relating to serial local audits was provided by AQuA, including data collected during the first 3 months of the AQ programme when teams received their first (baseline) reports of audit performance, and data from the latest available comparable 3-month period within the time frame of our analysis of administrative data (January-March 2018).

| Development and validation of diagnostic coding algorithm
The standard approach for identifying admissions within administrative data is to focus exclusively on the primary (principal) discharge diagnosis code. However, ARLD is a complex condition and can present with a spectrum of symptoms, signs, specific disease complications and with other co-existing alcohol-related disorders.
Inadequate identification of liver-related admissions based on primary diagnosis alone has been reported. 21 Hence, we needed to develop a better method for identifying cohorts of people with ARLD and their relevant emergency admissions from administrative data.
Each care episode contains up to 23 diagnostic codes, classified according to version 10 of the International Classification of Diseases (ICD-10). Using the regional dataset for all-cause admissions, we set out to define patterns of diagnostic codes consistent with acute presentations of ARLD (Table 1). First, we flagged admissions with any of the six specific codes for ARLD recorded as primary diagnosis (Table S1)-referred to as ARLD-Primary admissions and reflecting the standard approach. Next, we extracted admissions where such codes appeared in a nonprimary position and created frequency tables of the primary diagnoses recorded for those admissions. Two clinicians reviewed the tables independently, selecting primary codes compatible with emergency presentations of ARLD. Any discrepancies were resolved by informal consensus. This resulted in one code list for "symptoms, signs or complications" of ARLD (eg jaundice, ascites, oesophageal varices, acute kidney injury, infections/sepsis, encephalopathy; Table S2) and another for "other alcohol-specific conditions" (eg acute alcohol withdrawal or alcoholic gastritis; Table S3). Primary codes were rejected when judged to indicate that ARLD was not the main reason for admission (eg chronic obstructive airways disease).
We also identified other categories of admission where a code for nonspecific liver disease (eg other and unspecified cirrhosis of the liver; Table S4) co-existed with a code for an alcohol-specific condition-thereby suggesting the liver disease was alcohol related.
Using the clinician-generated list for symptoms, signs and complications, we defined which of these admissions were also eligible for inclusion. An algorithmic procedure was created to screen the dataset to identify admissions with any of the permitted coding combinations, referred to collectively as ARLD-Algorithm admissions. This included ARLD-Primary admissions plus the extra admissions identified from alternative coding patterns (ARLD-Uplift).
Algorithm performance was evaluated at one hospital as part of an audit of care by two independent clinician observers (BS and LA), each reviewing a series of consecutive patients (n = 49 and n = 48 respectively) who had been referred to alcohol services during an emergency admission. Review of manual and electronic records established whether or not the admission was related to acute management of ARLD with the two reviewers blinded to discharge TA B L E 1 Summary of diagnostic coding algorithm to identify admissions for alcohol-related liver disease (ARLD) within the administrative dataset. Each care episode in the dataset contains up to 23 diagnostic codes assigned by clinical coders after discharge, using the International Classification of Diseases 10th Revision (ICD-10) system. See Supporting information for full code lists.
The list of ICD-10 codes must conform to one of four patterns: 1. ARLD-specific code a recorded as primary diagnosis (ARLD-Primary) 2. ARLD-specific code recorded as a secondary diagnosis All higher order diagnoses must be either: (A) Symptom, sign or complication b , or (B) Other alcohol-specific diagnosis c 3. Nonspecific liver disease code d recorded as a primary diagnosis Lower order diagnoses must include one alcohol-specific diagnosis 4. Nonspecific liver disease recorded as a secondary diagnosis All higher order diagnoses must be either: (A) Symptom, sign or complication, or (B) Other alcohol-specific diagnosis (at least one must be recorded) a Six specific codes for alcohol-related liver disease (see Table S1).
b Codes for jaundice, ascites, varices, acute kidney injury, encephalopathy and other relevant diagnoses suggesting admission for ARLD complications (see Table S2). c Codes for other alcohol-specific conditions such as alcohol intoxication, withdrawal and organ-specific disorders (eg alcoholic gastritis; see Table S3). d Codes for liver disease without specific aetiology (eg cirrhosis, unspecified; see Table S4).
coding. Thirteen ARLD admissions were identified among the 97 cases. Discharge codes were then extracted and admissions classified by the primary and algorithm methods. We confirmed that ARLD-Primary approach had excellent specificity (100%) but poor sensitivity for detecting all relevant liver-related admissions (only 61.5%), whereas the algorithm had much better sensitivity (92.3%) while retaining high specificity (91.7%).

| Defining index admissions for ARLD
We aimed to study the outcome of emergency hospitalisation for  Figure 1A).

| Primary outcome
The primary outcome was death during an index admission for ARLD. This was established from the discharge method variable in the dataset which records death in hospital. 20

| Case mix variables
We extracted case mix variables for age, sex, co-morbidity and deprivation status of place of residence as previously described. 20 For co-morbidity we used Charlson co-morbidity Index as defined in the national Summary Hospital-level Mortality Index (SHMI), using the categorical version. 22 For category 1, the index is 0, category 2 has scores of 1-5 and category 3 is 6 and above. Deprivation status of place of residence was entered in our models using the Index of Multiple Deprivation Rank quintiles as defined at national level and we used quintile 5 (least deprived quintile) as the reference category as previously described. 20 Recognising the variable presentations with specific complications of ARLD, we also created code lists for varices, ascites and acute kidney injury. We screened all ICD-10 codes in each episode of the index ARLD admissions and created binary variables for these clinical characteristics. Addition variables included whether the admission was a short stay (<2 days) and whether higher level or intensive care was required.

| Identification of outlier hospitals prior to the intervention
Our first objective was to determine whether there had been unexplained variation in risk-adjusted mortality between hospitals prior to launch of the AQ programme, thereby identifying any "outliers" Expected deaths were determined using risk-adjustment procedures as described by Spiegelhalter. 23 Logistic regression models were constructed to estimate the probability of death at the end of each index admission within a fiscal year for each provider, thereby allowing expected deaths (E) to be calculated as the sum of those probabilities. To obtain these probabilities, we used stepwise binary logistic regression to determine adjusted odds of in-hospital death. Candidate independent variables included age group, sex, deprivation status, co-morbidity (Charlson score categories), ARLD-specific code recorded as primary diagnosis, disease-specific complications (varices, acute kidney injury, ascites), short stay status (<2 days) and requirement for higher level or intensive care.
By implementing stepwise selection of variables, we identified the combination of case mix variables that were significant predictors of in-hospital death. For this selection, we used conventional significance level thresholds for entering and removing case mix variables from logistic regression (P < 0.05 for entering and P > 0.10 for removing a variable) and used robust SEs to adjust for clustering of admission within patients.
The case mix variables included in the overall logistic regression model after stepwise selection (in order of entry into the model based on statistical significance) were: Acute kidney injury (P < 0.001); Requirement for higher level or intensive care (P < 0.001); ARLD-specific code recorded as primary diagnosis (P < 0.001); Age group categories (P < 0.001); Charlson score categories (P < 0.001); Ascites (P = 0.001); Short stay status (<2 days) (P = 0.002); Varices (P = 0.024). We compared performance of basic adjustment models (containing only generic case F I G U R E 1 (a) Comparison of traditional method (ARLD-Primary) and clinically designed algorithm (ARLD-Algorithm) for cohort discovery of index admissions for alcohol-related liver disease (ARLD) from routine administrative data (pooled data for seven hospitals for the period 2014/2015 to 2017/2018). The algorithmic approach identifies an "uplift" of 48% (ie potentially missed cases) with coding patterns compatible with an admission for symptoms, signs and/or complications of ARLD. See Table 1 for overview of diagnostic coding rules, and Tables S1-S4 for code lists. Index admission rate (standardised for age and sex) Low High mix factors) to more advanced models (using alternative sets of variables) by examining the proportion of variation in mortality explained (pseudo-R 2 statistic), and then adopted the optimum model for risk-adjustment.
For creating funnel plots, we used the funnelcompar command in stata statistical package version 15 (which is based on Spiegelhalter), 23 we identified whether SMR relative to the number of index admissions 24 was within acceptable limits (i.e. within 2 SD; 95%), between 2 and 3 SD, or beyond 3 SD (99.8%). An outlier in 2014/2015 (baseline year) was defined as a provider where SMR was beyond the upper 3 SD control limit.

| Comparison of risk-adjusted mortality for the pre-and post-intervention periods
We generated a series of funnel plots, one for each fiscal year, to illustrate time trends in the degree of inter-institutional variation, as previously described. 25 Having identified a group of outlier hospitals with "higher than expected" mortality prior to the intervention, we applied a categorical variable to represent all admissions to those hospitals throughout the observation period. This allowed risk-adjusted mortality models to examine time trends in mortality risk separately for outlier hospitals (where unexplained mortality had been identified) and non-outlier hospitals (where no such signals were present at baseline).
To test the significance of time trends in adjusted odds of death, we used fiscal year of admission as a categorical variable and designated the pre-intervention year (2014/2015) as the comparator. We also explored any individual hospital "effects," by adding a categorical variable to represent admission to each of the seven hospitals. This allowed us to test any specific associations for individual providers beyond their baseline grouping as outlier or non-outlier hospitals.

| Analysis of local audit data at the beginning and end of the observation period
We compared the locally collected audit data for performance on AQ process measures, pooling data for those hospitals identified as outliers and non-outliers for inpatient mortality for 2014/2015.

| Demographic and clinical characteristics
Over the 4 fiscal years, there were 3887 index emergency admissions for ARLD to the seven hospitals ( Table 2). The geographical distribution of the admissions and location of hospitals is shown in Figure 1B. The mean age at the time of index admission was 53 years, with men accounting for 63%. Over half (56.8%) were residents of an area classified within the most deprived quintile for the country, 15.5% were in quintile 2, 11.2% in quintile 3, 9.4% in quintile 4 and just 7.1% in quintile 5 (least deprived).
Overall, approximately one in five patients had ICD-10 codes consistent with acute kidney injury (21.7%), one in three had codes compatible with ascites (32.4%) and over one in six patients had varices (15.5%). The median length of stay was 6 days (IQR: 3-14). Short stays (<2 days) accounted for 14.1% of index admissions. There were 304 admissions that required a period of higher level or intensive care (7.8%), indicating severe disease complications.

| Variation in mortality between hospitals prior to the AQ programme and identification of outliers
We compared performance for risk-adjusted mortality (SMR) using funnel charts, plotting mortality vs number of index admissions. In the fiscal year prior to roll-out of the AQ programme (2014/2015), three hospitals had an SMR above the upper 3SD control limit (Figure 2A)suggesting special cause or unwarranted variation. Using stepwise logistic regression analysis, we further confirmed that patients admitted to the outlier group of hospitals had an increased adjusted odds of death (OR 2.13, 95% CI 1.32-3.44, P = 0.002) compared to those admitted to the non-outlier hospitals during that year (Table 3a). As expected from these observations, the magnitude of variation in SMR between the hospitals reduced significantly over the 4 years, with a standard deviation of 26, 28, 19 and 12 respectively. Taken together, these data provide evidence for a reduction in unexplained or potentially "avoidable" mortality and a narrowing of variation between hospitals.

| Associations between admission year and odds of death according to outlier status
We further examined time trends in a series of models. Taking the pre-intervention year as the reference year (2014/2015), there was a significant association between fiscal year of admission and a reducing odds of death for patients admitted to the three outlier hospitals (Table 4a). Admission in 2017/2018 was associated with a 67% reduction in adjusted odds of death compared to the pre-intervention year (OR 0.33, 95% CI 0.18-0.63, P = 0.001). Hence, for hospitals identified as having a high SMR prior to the AQ intervention, the risk of death was significantly reduced over time. This suggests a reduction in "avoidable" mortality.
There was no significant association between fiscal year of admission and odds of death for patients admitted to the hospitals that were not mortality outliers in the pre-intervention year (Table 4b). Hence, risk-adjusted mortality during index admissions was unchanged over time. This would be expected, as non-outlier hospitals were not identified as having "special cause" variation in mortality prior to the QI programme and so would have less TA B L E 2 Characteristics and outcome of index admissions for alcohol-related liver disease (ARLD) to seven acute NHS hospitals in the North West region of England. Stratified by fiscal year and survival status   Table 5b. These data suggest that care processes at outlier hospitals had greater scope for improvement at the start of the programme than at the non-outlier group. Furthermore, performance differences between the two groups of hospitals reduced over time.

| Comparison of locally collected audit data at outlier and non-outlier group of hospitals
The financial incentive scheme (annual CQIN payment linked to participation) was taken up by the commissioners of two non-outlier and one outlier hospital, suggesting that this financial incentive per se was not associated with the successful implementation.

| Performance of outliers and non-outliers on publicly available all-cause mortality statistics
We compared our findings for ARLD-specific mortality with publicly available statistics for all-cause hospital mortality for 2014/2015, based on the SHMI indicator. 22 Only one of the three outlier hospitals for ARLD mortality from our models had a SHMI above the national upper limit and none of the non-outlier hospitals. Hence, our "outlier" hospitals for ARLD mortality in the preintervention year were not identifiable as a group of providers that had a general pattern of unexplained all-cause mortality in routinely published statistics. This suggests our findings are relevant to acute care for ARLD rather than reflective of more generic institutional factors.

| D ISCUSS I ON
To our knowledge this is the first study to demonstrate a reduction in unexplained variation in hospital mortality for ARLD associated  Hospital with a QI programme. We began by determining whether there had been "unexplained" variation in mortality between hospitals prior to the intervention, confirming a number of outliers. As a group, the outlier hospitals had significantly poorer performance on 5 of 11 AQ measures (46%) at the start of the programme. Our analyses of independent administrative data showed that the adjusted odds of death for index cases admitted to "outlier" hospitals was significantly higher in the year before the AQ intervention (twofold). We were able to show that institutional performance improved over Our study has a number of strengths. Rather than focusing on data captured for samples of cases included in periodic local audits, we used administrative data as it is independent of the audit process and allows unbiased case ascertainment over a continuous observation period. By including a sample of hospitals with significant variation in baseline performance for mortality, our evaluation was able to explore trends for hospitals with, and without, outlying performance.
We applied clinically informed methods for interrogating administrative data. Lack of credibility for simplistic analyses of discharge coding among front-line teams has led to calls for better approaches to using administrative data to capture hospital activity for alcohol-related conditions. 28 We confirmed that for ARLD it was necessary to improve on the traditional "primary diagnosis" approach for cohort identification, developing a novel clinically designed al-

TA B L E 5
Local audit data for the Advancing Quality (AQ) process metrics a , comparing pooled data for the "outlier" and "non-outlier" group of hospitals. Significant differences in performance between the two groups on individual metrics are highlighted in bold text diagnosis alone may miss almost 40% of true admissions for ARLD, seriously under-estimating burden and risking the generation of misleading metrics. We focused specifically on index admissions to identify a fixed point in the care pathway and establish a more level playing field for institutional comparisons.
Further evidence for face validity of our cohort identification method is provided by comparing the characteristics of patients who died to that of the national sample of inpatient deaths reviewed by NCEPOD. 4 In that report, 20% of ARLD deaths occurred within 72 hours of admission (vs 22% in our study), mean age was 58 years (as in our study), gastrointestinal bleeding in 20.7% (vs 17% with varices codes) and ascites in 55.7% (vs 54% with relevant codes). The NCEPOD review only reported "established renal failure at presentation," but this was highly prevalent at 30% for those dying during admission (vs 66% with codes for acute kidney injury among deaths in our study). A recent study of people who died from liver disease in England identified renal complications as strongly associated with hospital death. 29 We focused deliberately on in-hospital mortality during index admissions as we believe this metric was of most relevance to the potential impact of the QI programme. The AQ measures were targeting the essential elements of acute hospital care in the early days of an emergency admission. We did not study post-discharge or longer term mortality, as these outcomes would be influenced by subsequent ambulatory hospital aftercare (eg liver clinics) and community-based alcohol services.
Our analysis of in-hospital mortality moved beyond simple generic risk-adjustment variables (age, gender, co-morbidity index, deprivation status) to include condition-specific case mix factors associated with liver disease severity and complications.
Sensitivity analyses explored models with alternative sets of variables to illustrate which factors were independently associated with mortality and to optimise final models. Compared to a simple, generic approach (pseudo-R 2 was just 5.5%), the proportion of mortality variation explained by the final model was sixfold greater (pseudo-R 2 , 30.7%). This suggests our condition-specific case mix factors were relevant surrogates for patient factors associated with death.
We propose that our methodology for analysing inpatient mortality for index ARLD admissions from administrative data could be adopted nationally, helping to identify potentially unexplained variation in outcomes of care at a key point in the care pathway.
This would support targeted reviews of service provision, organisation and care process-complimenting recent efforts to encourage formal accreditation of units under the Improving Quality in Liver Services (IQILS) programme. 30 By focusing on deaths during index admissions we have concentrated on acute secondary care for first admissions for ARLD, rather than the common approach of pooling together both admissions and remissions to generate "admission-level" mortality metrics that can be difficult to interpret.
This evaluation has a number of limitations. We cannot determine cause and effect from an uncontrolled observational study, and the temporal trends observed could have been driven by factors external to the QI programme. However, this does not negate the evidence presented for a narrowing of inter-institutional variation and a selective reduction in mortality risk at those hospitals that began the period as "outliers." This is good news for patients, regardless of precise mechanism. Our data suggest that it is, indeed, possible for hospitals to achieve reductions in potentially avoidable mortality for ARLD. The reasons for this improvement will be complex and multifactorial, but we believe it is reasonable to infer an impact of the QI programme.
General secular trends in population characteristics or health service improvements would not be expected to operate selectively at the three "outlier" hospitals and create no signals at the others.
Our review of publicly available metrics of hospital mortality revealed just one of the seven hospitals had "higher than expected" all-cause inpatient mortality in 2014/2015 (only one of the three "outliers" for ARLD mortality). This suggests our observations are condition specific rather than mirroring general trends of mortality at these hospitals.
There are well-known limitations to discharge coding data, including potential variations or inaccuracies and a lack of granular clinical information for case mix or laboratory data to allow true assessment of disease severity. However, the aim of our work was to develop better ways to use currently available administrative datasets to study outcomes of hospital care. It is hoped that future progress with structured electronic health records will enhance the opportunities for continuous monitoring of risk-adjusted outcomes at regional or national scales, with access to richer clinical variables such as laboratory parameters of liver disease severity.
However, for the time being we propose our methods could be applied to national administrative datasets to identify variation and support nationwide programmes focused on improving acute hospital care for ARLD. We have not attempted to compare characteristics of individual hospital services or to draw inferences about local factors associated with "outlier" status. Our aim was to establish that variation in mortality between providers was present before the QI programme started and that it reduced afterwards.

| CON CLUS IONS
This study challenges the pessimism and therapeutic nihilism that is prevalent for this vulnerable group of "hard-to-help" patients. 31 Lack of progress in policies for prevention has been highlighted recently, 32 emphasising the ongoing need to optimise acute services to deal with the ongoing demands for emergency liver and alcohol care. Notwithstanding the well-known limitations of an uncontrolled observational study, these data provide hope that co-ordinated efforts to drive adoption of evidence-based practice for acute care of ARLD can save lives. Further research is needed to identify the optimum bundle of interventions, quality metrics and implementation models needed to achieve sustained, servicewide reductions in avoidable inpatient deaths in the acute phase of care.

ACK N OWLED G EM ENTS
In addition to the authors (P.R., S.R and S.H.), the Clinical Expert