Cultivating conscience: Moral neurohabilitation of adolescents and young adults with conduct and/or antisocial personality disorders

Abstract Individuals diagnosed with conduct disorder (CD) in childhood and adolescence are at risk for increasingly maladaptive and dangerous behaviors, which unchecked, can lead to antisocial personality disorder (ASPD) in adulthood. Children with CD, especially those with the callous unemotional subgroup qualifier (“limited prosocial emotions”/DSM‐5), present with a more severe pattern of delinquency, aggression, and antisocial behavior, all markings of prodrome ASPD. Given this recognized diagnostic trajectory, with a pathological course playing out tragically at the individual, familial, and societal level, and lack of effective remediation via current standards of care, we posit an alternate treatment approach; case‐specific compulsory moral habilitation aimed at rectifying the undeveloped affective domain of adolescents and young adults suffering from these disorders. We begin with a brief historical overview of response to mental illness, review CD and ASPD diagnostic criteria and treatment limitations, and posit a unique neurohabilitative approach that focuses on the absent affective moral development of these populations. Next, we invoke a public health safety argument to justify case‐specific compulsory moral habilitation, discuss neurotechnologies to be considered in treatment, and conclude with ethical considerations and suggestions for further research.


II | HIS TORIC AL PER S PEC TIVE
The history of treatment for mental illness has been plagued by centuries of superstition, ignorance, and inhumanity. People exhibiting bizarre or deviant behaviors were often viewed as spiritually "sick", "guilty", or "possessed by the devil", requiring religious or punitive interventions. In the 18th century, medical generalists with peripheral interests in mental disorders, colloquially referred to as "maddoctors", 1 would make home visits to consult on family members exhibiting strange behaviors; family members who were kept out of public sight. But, with the dawn of the industrial revolution and people flocking to urban centers for work, mental illness became a more visible, and hence "societal" problem, as individuals exhibiting strange or frightening behaviors ended up in prisons or on the streets.
The next societal response to the chronically and acutely mentally ill would take the form of institutionalization in state-run mental facilities that became "dumping grounds" for populations of all ages and manner of physical, mental, and/or developmental disability.
Response to mental illness would shift from "management" to "treatment" in the late 18th, early 19th centuries, with the introduction of psychoanalysis and talk-therapies, and again in the 1950s, through pharmacologic administration of chlorpromazine (Thorazine) for the treatment of psychoses (e.g., in schizophrenia). But news reports of electroconvulsive shock therapies and psychosurgeries (lobotomies) performed with questionable consent practices in hospitals like Willowbrook 2 and Pilgrim State, sparked public outrage and cries for reform, leading to a protracted period of deinstitutionalization, and an overhaul of mental health treatment provision.
People living in societies are inculcated by the norms of societies in which they live-from the way they are raised, to the interpersonal behavioral responses expected. If behavioral norms are solely societal constructs, then, is it "just" that an individual who does not meet with a community's behavioral standards should be deemed mentally ill, be medicated, or even locked up? Though this certainly presents an argument in favor of personal liberty, an equally strong rebuttal in favor of societal "contract" posits that, as members of a community, some behavioral deviance from the proscribed norm is acceptable; however, once the deviant behaviors present potential or actual harm to self or others in the community, legally sanctioned protections (e.g., involuntary psychiatric hold, sometimes called a "civil commitment") may be invoked.

III | DE VELOPMENT OF MOR ALIT Y
Developmental psychologist Lawrence Kohlberg posited that moral deliberative ability does not fully emerge until late adolescence. 3 But studies of infants and toddlers bear out that early moral intuitions seem to manifest long before human capacity for complex reasoning is neurologically developed. 4 Studies show that infants are sensitive to the valence of third-party social interactions, displaying a preference for prosocial agents over antisocial or neutral ones. 5 This was demonstrated when infants observed puppets either helping or hindering other puppets; infants as young as 3-month-olds gazed significantly longer at the helpful puppets. 6 Likewise, 6-and 10-month-old infants exhibited longer gaze time, and actively reached towards prosocial characters, not the antisocial ones. These "third-party moral evaluations are thought to rely on intuitive processes that constitute the foundations for an innate moral core shaped by natural selection to facilitate social affiliation and collaboration" (p. 156). 7 3-4-year-old children consistently judge antisocial transgressions (e.g., hitting another child) not only as wrong, but wrong across situational contexts. 8 Children observing other conspecifics being harmed triggers empathic concern, "particularly when the harm is inflicted intentionally and is unjustifiable. Empathic concern is critical in moral cognition" (p. 158). 9 Neuroscientific studies employing functional magnetic resonance imaging (fMRI), eye tracking, and pupillometry of children and adolescents 10 support a "gradual maturation and integration across distinct neural computations in service of moral evaluation" (p. 159). 11 When functional MRI studies are conducted with children and adolescents manifesting disruptive psychopathic traits, it has been demonstrated that these individuals, when viewing the suffering of others, exhibit reduced activity in brain regions typically implicated in affective responses to others' pain; these regions include the anterior cingulate cortex, insula, and amygdala. 12

| A. Conduct disorder
Conduct disorder (CD) in children is defined as a repetitive and persistent pattern of behavior that violates the rights of others and age-appropriate societal rules. 13 According to the Fifth Edition of the Diagnostic and statistical manual of mental disorders (2013), 14 a diagnosis of CD requires the presence of three of 15 criteria (behaviors) manifesting within the previous 12 months, at least one of which has presented for the past 6 months. These 15 behaviors are categorized into four dimensions: aggression to people and animals; destruction of property; deceitfulness or theft; and serious violation of rules (e.g., running away from home). For a diagnosis of CD, the behavioral symptoms must cause clinically significant impairment in social, academic, and/or occupational functioning.
An additional specifier of "limited prosocial emotions" was introduced to the DSM-5 to describe a subgroup of those with CD who also present with callous unemotional (CU) traits. To qualify for this specifier, a child must have displayed at least two out of four characteristics persistently over the previous 12 months across multiple relationships and settings. These characteristics are: lack of remorse or guilt, callousness (e.g., lack of empathy), lack of concern about performance (e.g., in school), and shallow or deficient affect. Individuals who meet criteria for the limited prosocial emotions specifier are more likely to engage in aggression that is planned for instrumental gain. 15 It is important to note that within the CU subgroup specifier, it is the affective, or emotional, component of empathy that is absent or impaired, not the cognitive or reasoning ability (e.g., perspective-taking, assessing others' thoughts, theory-of-mind or mentalizing). This functional impairment has been associated with reduced amygdala and ventromedial prefrontal cortex responsiveness to distress cues. 16 Developmental accounts of CU traits place primary emphasis on biologically based factors; 17 CU traits are associated with functional abnormalities in brain regions involved in the processing of basic emotional salience, reinforcement learning, and emotion regulation (e.g., amygdala, ventromedial, prefrontal, orbitofrontal cortex, and caudate 18 ). Disorders often comorbid with CD include ADHD, anxiety, depression, and substance abuse. 19 Adolescence is a dynamic, developmentally important period of life, characterized by sweeping changes of physical maturation, increased reliance on social/peer interactions, and significant physiologic brain development. These social-relational and neurodevelopmental processes significantly impact adaptive functioning during adolescence and emerging adulthood. 20 Prosocial, and associated negative emotions of guilt and shame, are thought to be of particular importance for the maturing adolescent, serving to maintain attachments, and acting as "'social regulators' that encourage a balance between one's self-interested motivations and the rights and needs of others" (p. 51). 21 Here, a distinction between guilt and shame must be made; guilt is associated with selfblame related to one's own behavior, whereas shame is associated with self-blame and a pervasive view of one's global self as "faulty". 22 This distinction is important, due to the different ensuing responses and behaviors. Guilt is associated with feelings of regret and remorse and is the counterpart to prosocial tendencies associated with empathy. Conversely, shame is thought to be associated with feelings of helplessness, and a desire to hide or escape. 23

| B. Antisocial personality disorder
A diagnosis of CD in childhood or adolescence often precedes that of ASPD in adulthood. 24 While not all cases of CD progress to a diagnosis of ASPD, "empirical studies have demonstrated a strong link between the two" (p. 19). 25 Antisocial personality disorder (ASPD) describes individuals with a pervasive pattern of disregard for, and violation of, the rights of others that begins in childhood or early adolescence and continues into adulthood. Epidemiological studies report a prevalence of 2-3% in the general population, with estimates of approximately 3% in men and 1% in women. In prison samples, studies have found rates of ASPD to be 47% in men and 21% in women. Often the terms sociopath, psychopath, and ASPD are used interchangeably, but they are not the same; this confusion likely stems from overlapping traits. Antisocial personality disorder has "perhaps the most overlap with the construct of psychopathy" (p. 427). 27 Psychopathy, while not recognized in the diagnostic criteria of DSM-5, describes individuals with many of the features of ASPD, but who manifest additional characteristics such as superficial charm, manipulativeness, callousness, and shallow affect. 28 Evidence from a growing body of research suggests that there are variants of psychopathy; variants that are phenotypically similar, but "primary psychopathy is underpinned by a (heritable) affective deficit, whereas secondary psychopathy reflects an (environmentally acquired) affective disturbance" (p. 395). 29 Since the secondary psychopath's callous behavior can be understood as an emotional adaptation to childhood trauma (e.g., caretaker rejection or abuse), secondary psychopaths are viewed as more amenable to treatment than primary psychopaths. 30 For years, attempts have been made to treat antisocial individuals using a variety of clinical approaches, including individual and/or group therapies, behavior modification programs, parent/family education, and medication administration. Unfortunately, though, there are still no truly effective treatments available for these populations. Many clinicians have adopted the position that antisocial individuals, especially those with elevated levels of psychopathy, are "so difficult to treat as to be next to untreatable" (p. 264). 31

V | PUB LI C HARM AVER S I ON
Western society's emphasis on individual liberty aligns with a medical ethical emphasis on patient autonomy. When a patient is deemed to have decision-making capacity, she can refuse medically beneficent care for herself, although she cannot exercise the same for her minor child, wherein courts will intervene on behalf of a minor who is at-risk of harm. Adults diagnosed with psychiatric illness retain decision-making autonomy, unless they exhibit threat of imminent harm to self or others, at which point they can be involuntarily hospitalized. There is also a professional "duty to warn" anyone being threatened of harm when such a threat is known. 32 Personality disorders, with ASPD the most common category, are very prevalent in the prison populations. 33 And offenders with personality disorders, especially of a psychopathic type, exhibit a higher risk for violent crime. 34 In 1999, the UK government introduced the Dangerous and Severe Personality Disorder (DSPD) program "to deal with a group of individuals who … were at the boundary between the health and criminal justice systems" (p. 325). 35 DSPD is not a clinical classification, but a determination that an individual presents a significant risk of inflicting serious physical or psychological harm upon others, a risk-factor functionally linked to a personality disorder. In spite of opposition by many in the mental health and legal communities, the DSPD program exemplifies a health policy initiative wherein public safety concerns supersede individual autonomy in cases of those meeting specific diagnostic criteria and extremes of behavior.
Considering the high percentage of incarcerated individuals suffering from ASPD, and the lack of treatment effectiveness (i.e., high rates of recidivism) when individuals with ASPD end up in the mental health system, there is an urgency to consider alternative treatment strategies in efforts to ameliorate costs and burdens on the mental health, criminal justice, and emergency response systems. People suffering from these serious personality disorders are the least likely to seek out, or comply with, treatment strategies due to narcissistic tendencies, lack of remorse, and externalization of blame.
In light of these factors, we argue that case-specific compulsory moral neurohabilitation would be justified, so long as treatment/ safety protocols are in place. Too many atrocities have occurred via medical, governmental, and religious abuses of power in the name of societal "good" (e.g., eugenics, human experimentation, incarceration of political dissidents, etc.). Understandable concerns arise from fears of diagnostic-creep, political influence, religious, and/or social pressures. Adequately addressing these concerns will require implementation of multiple procedural safeguards, including professional diligence, empirically verified treatment strategies, ongoing case review, and accountability. Only with these "ground-rules" in place, do we propose that there may be "instances where a compulsory moral enhancement might actually be more responsible of the state than leaving such interventions up to individual choice" (p. 203). 36 We agree with Wiseman who asserts that it "is not whether the intervention is voluntary or compulsory that gives it decisive moral significance, but rather it is the facts on the ground that determine whether the intervention should be voluntary or compulsory" (p. 203). 37 27 Ibid. 28 Ibid.

| A. Habilitation
Persson and Savulescu (2008) have posited that there is "an urgent imperative to enhance the moral character of humanity" (p. 162) 38 due to modern-day ability to wreak havoc on a global scale (e.g., bioterrorism), as compared to ancient hunter-gatherer/agricultural societies with limited tools, weapons, and reach of harm. But, while we recognize that there are ever-widening gaps between human (biological) evolutionary adaptive processes and ethical challenges posed by rapid technological advancements, we do not argue for species-wide enhancement or intervention in this paper.
Rather, we argue for case-specific neuro habilitation; a process aimed at helping individuals born with, or incurring, pathologies that prevent them from functioning within-range of societal norms and expectations.
To be clear, we do not espouse or suggest a reductionist view of morality-there is not one, isolated moral center of the brain, nor is there one consensual view of morality. In the next section we review empirical findings in support of our proposal for an affective moral focus, with proposed moral habilitation centered on stimulating and eliciting affective responses more consistent with those exhibited by the general population-affective responses that can be self-reported (e.g., feelings of guilt or distress), physiologically detected (e.g., galvanic skin response), neurologically observed (e.g., fMRI studies), and qualitatively assessed (e.g., pro-social, affiliative behaviors, interpersonal accountability).
Empirical findings (discussed in Diagnostic criteria for conduct disorder in Section 4) of reduced amygdala and ventromedial prefrontal cortex responsiveness to distress cues, 39 the brain regions normally associated with affective response when witnessing others in pain, 40 are consistent with our own clinical observations from decades of counseling at-risk youth-that CD and ASPD individuals are lacking innate moral intuitions essential for conscience development. We would assert that, just as attempts to counsel someone who is paralyzed by debilitating anxiety is ineffective until pharmacologic intervention is introduced in conjunction with talk-therapy, any continued attempts to counsel adolescents lacking prosocial moral intuitions about the importance of perspective-taking, selfreflection, and/or self-regulation is an exercise in futility (for adolescent, and counselor alike) until these moral intuitions can be biochemically elicited or primed. Understanding the biological basis of moral intuition and behavior helps shed light on why standard therapeutic approaches (e.g., cognitive behavioral therapy) remain ineffective treatments for these populations. These therapeutic strategies typically focus on correcting "faulty" cognitive reasoning processes related to moral judgments, but it has been demonstrated that psychopaths "show excellent (not poor) moral reasoning ability when discussing hypothetical situations" (p. 209). 48 The missing factor is the feeling of what is moral in antisocial individuals, not the knowing of what is moral. 49

| B. In support of an affective moral focus
As children grow and mature, so do their cognitive moral reasoning abilities; moral behaviors are understood to emerge from a dynamic of moral reasoning and moral emotions that "work in synergy and reciprocally influence each other" (p. 6). 50 Conflicting moral decisions do not entail a conflict between emotion and cognition, but rather invoke both via "cortico-limbic assemblies encoding distinct motivationally salient goals…to overcome a motivationally laden choice" (p. 164). 51 It has been demonstrated that adolescents who do not systematically learn, form, and internalize moral standards are more "susceptible to external risk factors for deviance" (p. 5). 52 Studies demonstrate that a youth's initial onset of delinquency is linked with "moral insensitivity and internal pleasure" (p. 5) 53 derived from risky behaviors, and continuity of delinquency further impacts moral development.
Individuals who can regulate their emotions are "more likely to experience empathy, and also to act in morally desirable ways with others" (p. 11). 54 Chronic incapacity to suppress negative emotions is a key factor leading to aggressive and violent behaviors. 55 There is an important distinction to be made between reactive and instrumental aggression; reactive aggression occurs as an explosive response to perceived threat or frustration and is not goal-directed, whereas proactive or instrumental aggression is used to achieve a goal or elicit a reaction. While reactive aggression is common in most personality disorders, predatory aggression is more common in performance anxiety and it has been investigated as a treatment or prophylactic for posttraumatic stress disorder (PTSD). PTSD, according to one widely accepted theory, arises from the over consolidation of traumatic memories. 66 Propranolol acts to block the transmission of a neural signal by "blocking adrenergic receptors in the amygdala, a limbic brain region strongly linked with … emotion processing" (p. 5). 67 While the focus of this paper is on "primary" psychopathy (instrumental aggression/CU subtype) with a strong genetic/biological underpinning, "secondary" psychopathy (reactive aggression) has a greater environmental influence. 68 Early childhood stress and trauma, with inconsistent and/or harsh parenting styles, and maladjusted attachment can exacerbate and contribute to the antisocial behavioral responses in these populations. Many of these adolescents and young adults have concurrent diagnoses of PTSD; perhaps traumatic memory consolidation would prove beneficial in ameliorating dysfunctional interpersonal interactions (e.g., aggression towards people/places/events that elicit painful memories).
Oxytocin is produced naturally in the brain's hypothalamus and released into both the brain and bloodstream. This hormone and neurotransmitter is best known for its somatic effects, facilitating birth and breastfeeding in humans and other mammals, but it may also influence morally significant behavior. For example, in (nonhuman) mammals, oxytocin seems to mediate pair bonding, maternal care, and other prosocial behaviors, 69 and studies suggest that it plays a role in mediating trust, cooperation, empathy, and generosity in humans. Similarly, glucocorticoids, widely used to treat asthma and other disorders of inflammation, "are thought to modulate both the release and activity of oxytocin" (p. 118). 70 71 In animal studies, oxytocin administration has served to normalize emotional contagion and decrease aggression, thereby ameliorating the phenotype of mice "characterised by abnormal aggression and excess callousness" (p. 251). 72 The hypothesis of oxytocin increasing prosocial behaviors has been challenged by studies associating oxytocin with maladaptive behaviors. For example, one study demonstrated oxytocin administration heightened envy during a gambling game. 73 Another study revealed increased plasma oxytocin levels in women experiencing emotional distress when encountering relationship threats to monogamous pair bonds. 74 There has also been a concern raised that oxytocin's increased trust effects may be sensitive to in-group membership; e.g., in one study, participants administered intranasal oxytocin who viewed trolley dilemma scenarios were "significantly more likely to sacrifice a different race individual to save a group of race unspecified others than they were to sacrifice a same race individual" (p. 120), 75 an in-group bias not demonstrated by participants in the placebo group.
Another hormone and neurotransmitter recognized for its prosocial behavioral effects is the neuropeptide arginine vasopressin (AVP). 76 AVP plays a key role in pair bond formation, parental care, and social approach across animal species. Empathic concern is the primary motivator of prosocial behavior and "multiple studies have shown that AVP increases human prosocial behavior" (p. 254). 77 A randomized, double-blind study tested the effects of intranasal administration of vasopressin compared to placebo on empathic responses, demonstrating that in "participants with higher levels of primary psychopathy vasopressin increased personal distress and empathic concern compared to placebo" (p. 58). 78 Sex-dependent evidence from animal and human studies demonstrates that while oxytocin is more influential in female prosociality, arginine vasopressin may play a greater role in stimulating male prosociality. 79 Based on these studies, we would suggest that administration of oxytocin in women, and arginine vasopressin in men, can function as a prosocial "primer" wherein positive, affiliative behaviors can be elicited; the same prosocial default from which emotionally healthy individuals generally respond. Although some have argued that increased trust of others does not always result in good outcomes (e.g., increased trust can result in exploitation), adolescents and young adults exhibiting CD and/or ASPD seem, across the board, to be more distrusting and manipulative than others in their peer group, so it is unlikely that increasing trust levels in this population would become as problematic as increasing trust levels in a population already disposed to be trustful.

| Optogenetics
Optogenetics is an exciting neuromodulation technology that can manipulate biological processes via genetic modification of neurons to express light activated proteins (opsins), offering cell-specific neural control with millisecond precision. 80 Using this technique, recent studies have shown that specific neurons in the ventromedial hypothalamus (VMH) of mice, the region of the brain associated with satiety, can be manipulated in the regulation of male attack behaviors. 81 Through optogenetic inhibition of the VMH, attack responses were suppressed; researchers succeeded in manipulating dramatic behavioral changes in mice "from the highly prosocial to the extremely antisocial" (p. 61). 82 In another study, optogenetic stimulation of light-sensitive protein located in the basolateral amygdala of mice reduced anxiety-like behaviors and elicited an antidepressant-like response. 83 Unlike electroconvulsive therapy (ECT), administered in severe cases of pharmacoresistant depression, which indiscriminately stimulates large parts of the brain, optogenetics offers a much more targeted stimulation approach. 84

| Other devices
In addition to hormonal and optogenetic modulation strategies, there may also be uses of brain stimulation devices to reduce impulsive or addictive behaviors and improve self-control, thus "making associated 'immoral behavior' less likely" (p. 167). 85 Research has shown that disruptive stimulation of the right prefrontal cortex or the temporoparietal junction can affect moral judgments relating to fairness and harm; though the "circumstances of these … investigations have been thus far largely contrived, such that the real-world implications of the findings are not yet apparent" (p. 167). 86 Repetitive transcranial magnetic stimulation (rTMS) studies use low frequency rTMS to create "a 'functional lesion' to test hypotheses regarding whether specific brain regions are necessary for specific moral judgments" (p. 2). 87 Transcranial direct current stimulation (tDCS) studies examine whether increasing (anodal) or decreasing (cathodal) cortical excitability in a particular brain region will alter moral behavior. Anodal stimulation of the right dorsolateral prefrontal cortex (DLPFC) "increased decisions to trust and cooperate, indicating a general enhancement of prosocial behavior … (and) the willingness to intervene to help others in simulated situations" (p. 6). 88

VII | E THIC AL CONS IDER ATIONS
The first pharmacotherapeutic trials of childhood psychological disorders took place in the 1930/40s, when stimulants were administered to institutionalized hyperactive children. 89  Justice arguments in support of mandated neurohabilitation include increased societal safety, and decreased reliance on emergency medical and law enforcement personnel, freeing up these valuable resources to others who may need them. To ensure that prejudice and bias do not impact case-specific determinations, criteria for compulsory moral habilitation would have to be clearly defined and consistently implemented, determinations would be made by more than one licensed mental health professional, and there would be ongoing monitoring and accountability. Additionally, treatment access and cost-coverage must be assured through federal and state funded programs.
Would moral neurohabilitation change the person's identity?
This is a challenging question, as interpretations of personhood and identity vary based on philosophical framework, psychological construct, socio-cultural lens, or legal definition applied. Personhood or identity can be framed philosophically (e.g., ability to reason or reflect), psychologically (e.g., self-identity narrative, personality traits), morally (e.g., value systems, behaviors), relationally (e.g., cultural/ social embeddedness), biologically (e.g., system function, sentience, physiology, genetic composition), and legally (e.g., entity, rightsbearer, contract participant). Conflicting opinions abound as to whether one becomes "a different person" following certain medical interventions, events, or experiences, such as neurological procedures (e.g., deep-brain stimulation); 96 neurodegenerative disease (e.g., Alzheimer's); 97 life experiences (e.g., emotional trauma); 98 addictive behaviors (e.g., substance abuse); 99 or medication administration (e.g., attention deficit hyperactivity disorder/ADHD). 100 A study exploring the change-in-identity question conducted by Strohminger and Nichols (2014) 101 revealed that when study participants read vignettes of people who manifested behavior changes due to four conditions-agnosia (lost ability to recognize objects), apathy (lost desire), amnesia (lost memory), or morality (lost moral conscience)-with participants asked to comment on which individuals exhibited the greatest identity change, there was strong agreement that vignettes describing people who lost their "moral conscience" were "considered to be more of a different person than in any other condition" (p. 124). 102 Other studies have been conducted 103 with similar results, wherein moral traits are ascribed as essential to personal identity. Based on these findings, it might be deduced that someone gaining "moral conscience" following treatment would also be viewed as exhibiting significant identity change.
However, self-and other-views of identity change, and accompanying assessments of whether such changes are good or bad, welcome or unwelcome, will depend upon whose lens, and in what context, these evaluations are being made. Lacking capacity for self-insight, the ASPD individual's determinations of better or worse will have no baseline points of reference from which to make comparisons, making such assessments less reliable than those of family members, peers, and/or and others in the community with whom the individual interacts.
The informed-consent guidelines of the American Academy of Pediatrics (2016) 104 recommend practitioner efforts to obtain child and adolescent assent, in addition to parental/guardian consent, for medical treatment or research participation. This not only helps ensure treatment compliance, but validates an adolescent's autonomy for decision-making. 105 In recognition of increased adolescent decision-making capacity, "Mature Minor" legislation has been enacted in many U.S. states, granting permission for adolescents to seek out reproductive health services, substance abuse and mental health treatments without parental consent. 106 In some circumstances, the courts have upheld adolescents' rights to refuse invasive or chronic medical treatments/interventions dependent on case-based determinations of cognitive/emotional maturity. 107 But placing high dependence on adolescent decisionmaking poses problems when there is little incentive for the adolescent to seek treatment on her own (e.g., substance abuse) or when there is little to no insight, or personal accountability, of maladaptive behaviors impairing daily functioning, socialization, and emotional growth.
We contend that in applying risk-benefit assessments weighting potential harms of autonomy-infringement against those of community harms, some factors can be controlled, while others cannot-specifically, society can institute and monitor stringent procedural safeguards against individual rights-infringement, whereas society cannot, post-facto, restore the lives lost or fully ameliorate the trauma incurred by family members and friends of victims.
Mental health practitioner "duty to warn" 108 can only legally be invoked when a patient articulates a specific plan of inflicting imminent harm upon a specified individual. This legal mandate is insufficient, leaving desperate family members and trained clinicians frustrated and disempowered; individuals with these diagnoses do not seek out (or continue) treatment, do not articulate to others their specific plans to harm, and do not experience normative psychophysiological warning systems in the form of moral distress, guilt, or interpersonal accountability that would serve to thwart these dangerous impulses.

VIII | DUAL ROLE CHALLENG E S
Mental health practitioners, especially those working in a forensics capacity (i.e., psychiatrists), are tasked with the dialectical tension of maintaining a therapeutic alliance with patients, while simultaneously serving as court consultants rendering determinations of culpability in criminal proceedings or dangerousness to society leading to involuntary holds. Which of these "dual role" or "dual loyalty" dilemmas 109 responsibilities takes priority will depend on various factors, ranging from the views of individual practitioners, to those of employer/institutional expectations, to legal/ safety considerations, etc. In a recent qualitative study, wherein forensic psychiatrists were asked whether "stimulating moral development or moral growth is or should be part of forensic psychiatric treatment" (p. 75), 110 many respondents answered that while morality and conscience development are implicit aspects of treatment, they are not overt. Some expressed fears of misconception about the scope or expected outcomes of their services, while others cited concerns about imposing personal beliefs or value judgments. But we would remind practitioners that there are times when beneficent care requires non-neutrality. This holds true both in medical and mental health care contexts. Not only is it unrealistic for practitioners to maintain a wholly non-judgmental stance towards the psychopathic patients they treat, these pronouncements pose different kinds of challenges; specifically, implicit rather than overt treatment objectives can undermine the physician-patient relationship, maintaining a professional balancing act of "dual loyalty" contributes to practitioner feelings of emotional distress and burnout, and, by not openly and explicitly acknowledging a treatment goal of morality/conscience | 347 TUCK and GLEnn development, there are missed opportunities for dedicated research/funding towards this area of treatment potential.

IX | CON CLUS ION
When behaviors or actions jeopardize the health and safety of societyat-large, public health laws and procedures can override individual autonomy for the greater good. In any treatment provision (compulsory or not), the benefits of medication and/or technology use must always outweigh the harms. There is much more research needed regarding uses and effectiveness of any of the moral neurohabilitative options reviewed here. The most immediately translatable option would be SSRIs or other medications already utilized, but with research dedicated to testing for increased moral, prosocial effects. We also recommend research on the administration of oxytocin, or arginine vasopressin, in conjunction with counseling, to determine whether affective "priming" helps CD and ASPD adolescents/young adults to exhibit affiliative, intuitively driven moral behaviors. A holistic approach to any medical treatment is prudent; experimental clinical neuromodulation protocols should always be accompanied by counseling, case monitoring, and patient feedback. Perhaps one day in the not too distant future, adolescents and adults diagnosed with CD and ASPD may finally be helped to care about others, enjoying the rewards that come with healthy interpersonal interactions, empathic concern, and social affiliation. And the people with whom they interact will no longer have to live in fear.

CO N FLI C T O F I NTE R E S T
The authors declare no conflict of interest.