Safety and effectiveness of intranasal dexmedetomidine together with midazolam for sedation in neonatal MRI

Magnetic resonance imaging (MRI) has been consistently indicated as the imaging modality of choice in children and neonates. MRI is pivotal for the management and prognostication of different neonatal conditions including neonatal encephalopathy, preterm birth and congenital heart diseases. While feed and wrap technique may be used to perform MRI scans without sedation, this is not always possible due to MRI sensitivity to motion artifacts and long duration of the procedure.

Magnetic resonance imaging (MRI) has been consistently indicated as the imaging modality of choice in children and neonates. MRI is pivotal for the management and prognostication of different neonatal conditions including neonatal encephalopathy, preterm birth, and congenital heart diseases. While feed and wrap technique may be used to perform MRI scans without sedation, this is not always possible due to MRI sensitivity to motion artifacts and long duration of the procedure.
Many scans do not require contrast and the intranasal route offers an effective and relatively non-invasive way to deliver medications. Therefore, the ideal sedation regimen should obviate the need for an intravenous access, but still enable the completion of the MRI without deep sedation and subsequent complications.
Dexmedetomidine is a highly selective α2 adrenergic receptor agonist, which induces dose-dependent sedation, anxiolysis, and sympatholysis with respiratory drive preservation. Although it has been increasingly used in pediatric sedation for diagnostic imaging, little it is known on its safety and efficacy for procedural sedation in newborns.
Recently, the Pediatric Sedation Research Consortium reported the data regarding the safety and efficacy of intranasal dexmedetomidine for sedated MRI examinations in children. 1 The authors found 224 sedation encounters, 216 (96.4%) of which, also received intranasal midazolam. In all these cases, no major nor minor adverse events were reported.
However, no neonates were included in the study.
Bua et al. 2 assessed the use of dexmedetomidine as midazolamsparing drug to achieve sedation for MRI in 53 preterm neonates scanned at term equivalent age. The authors reported a good safety profile of dexmedetomidine without the need of any medical intervention during the MRI scans. However, in almost half of the infants (49%), one or more doses of midazolam were needed as adjunct to complete the procedure. Moreover, no data on the duration of the MRI scans, degree of sedation, or the quality of images were provided.
The primary aim of our study was to assess safety and effec- In all the infants, we placed peripheral venous access before the scan and adjusted feeding times (last feed 2 h before the scan), minimized noise with double-layered hearing protections and light with eye shields during all the scans. The degree of sedation before and after drugs administration was assessed by using N-Pass Score. A single researcher (PM) scored image quality from 1 (poorest) to 5 (best) for T1 and T2 images based on gray-white matter differentiation, deep nuclei organization, and the absence of motion artifact, on axial images. An overall quality score of 1-5 was given based on both T1 and T2 scans.
Adverse effects of sedation were defined as cough, bradycardias (heart rate <100 beats per minute), desaturations (oxygen saturation   Need for supplemental oxygen 2 (2) 0 4 (4) Note: Data are presented as n (%) for categorical variables and median (inter-quartile range) for continuous variables. a Sedation failure was considered if the MRI scan had to be interrupted because of motion and/or awaking of the neonate or a further dose of either the same or another sedative agent was required.
We recorded if any medical intervention such as head repositioning or stimulation was needed. Table 1 shows demographic, clinical features and sedation performance. The median time to achieve sedation was shorter in the midazolam group. However, sedation failure rate was lower, and the median quality score of the scans was higher in the dexmedetomidine plus midazolam group. The regression model adjusted for gestational age at birth, sex, weight, and gestational age at MRI, showed that dexmedetomidine and midazolam alone groups had higher odds of sedation failure (OR 6.6, 95% CI 2.8-15.1 and OR 11.6, 95% CI 5.3-25.3, respectively, p < .0001). Desaturations were not self-limiting in six cases (two in the dexmedetomidine plus midazolam and four in the midazolam alone groups) but responded promptly to supplemental oxygen.
No other interventions or assistance was required for any participants.
Our data show that the use of intranasal dexmedetomidine together with midazolam provided an adequate sedation even in scans of long duration, with low risks of significant adverse effects and high-quality images. Although dexmedetomidine offers favorable sedation profile with minimal respiratory depressant effects, it has slow onset of action when compared to other sedatives. The combination of dexmedetomidine and midazolam increased the efficacy of procedural sedation in neonates and can be considered an option in case of MRI scans of long duration.
In conclusion, intranasal dexmedetomidine as an adjunct to intranasal midazolam offers relatively efficient and effective sedation with minimal adverse effects for neonatal MRI scans when compared to intranasal dexmedetomidine or midazolam alone. Intranasal route offers a viable alternative for neonates who do not have an indwelling intravenous access at the time of their scan.

CO N FLI C T O F I NTE R E S T
None.

E TH I C A L A PPROVA L
The study protocol was approved by the University of Campania "Luigi Vanvitelli" ethics committee.

ACK N OWLED G EM ENT
Open Access Funding provided by Universita degli Studi della Campania Luigi Vanvitelli within the CRUI-CARE Agreement.
[Correction added on 20 May 2022, after first online publication: CSAL funding statement has been added.]

DATA AVA I L A B I L I T Y S TAT E M E N T
Data are available upon reasonable request and once all the different substudies have been published.