Primary intrathoracic liposarcoma: a clinical analysis of 31 cases

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Dear Editor,
Liposarcoma is a common soft tissue malignancy in adults. It most commonly occurs in the deep soft tissue of the extremities and retroperitoneum. Primary intrathoracic liposarcoma is rare, represents 2.7% of all liposarcomas [1]. According to the distinct tumor locations, it can be divided into mediastinal, pleural, and pulmonary liposarcomas. Most literature has reviewed the clinicopathological or molecular cytogenetic characteristics of mediastinal and thoracic liposarcomas [2,3]. However, intrathoracic liposarcoma is poorly documented because of its rarity. Complete surgical resection is thought to be the best treatment for primary intrathoracic liposarcoma, but the impact of radiotherapy and systemic therapy remains unclear. Therefore, we analyzed the clinicopathological data of 31 patients with primary intrathoracic liposarcoma who were treated in the Cancer Hospital of Chinese Academy of Medical Sciences between October 1970 and July 2015 to explore their clinicopathologic features and treatment outcomes (Additional file 1: Table S1).

Clinical characteristics
In the present study, the median age of the 31 patients with primary intrathoracic liposarcoma was 45 years (range 20-64 years), which was the same as the age of patients with primary extremity liposarcoma reported by Moreau et al. [4]. However, the mean ages of primary intrathoracic liposarcoma patients reported by the other two studies were 43 and 58 years [2,5].
We found that the most common initial symptom of intrathoracic liposarcoma was chest tightness (13 cases, 41.9%). Additionally, 6 (19.4%) patients were asymptomatic. However, Burt et al. [3] reported that the most common symptoms of patients with mediastinal liposarcoma were chest pain, dyspnea, wheezing, cough, and weight loss. Dei et al. [6] reported that mediastinal liposarcomas were often asymptomatic until they reached an appreciable size, at which point the symptoms were caused by direct invasion or compression of the heart, great vessels, or lungs.
We also observed that the percentage of patients with tumors located in mediastinum was 77.4% (24 cases), which was much higher than that (37.5%) reported by Hahn and Fletcher [5]. Of the 24 patients with mediastinal liposarcomas, 8 (33.3%) had tumors located in the posterior mediastinum, and 16 (66.7%) in the anterior mediastinum. However, Gladish et al. [7] reported that intrathoracic soft tissue sarcomas were often found in the lungs, mediastinum, pleura, pericardium, heart, and chest wall, whereas Unal et al. [8] found that they were most frequently localized on the chest wall and lungs.
Three patients had received chemotherapy: 1 (33.3%) had adjuvant chemotherapy and 2 (66.7%) had neoadjuvant chemoradiotherapy. The chemotherapy regimens used to treat these patients included adriamycin plus ifosfamide and epirubicin plus ifosfamide.

Survival outcomes
The median follow-up time in this study was 77 months (range 10-403 months). Disease progression appeared in 26 (83.9%) patients, including 20 (64.5%) with local recurrence and 11 (35.5%) with distant metastasis. Thirteen patients developed local recurrence only once with a median interval of 28 months (range 2-160 months), 4 developed twice with a median interval of 30 months (range 8-120 months), and 3 developed three times with a median interval of 15 months (range 12-24 months). Eleven (55.0%) patients with local recurrence underwent surgery. The median local progression-free survival (LPFS) was 44 months (range 2-214 months). The 3-and 5-year LPFS rates were 53.8% and 37.2% (Fig. 1). All the patients diagnosed with myxoid, dedifferentiated, and pleomorphic liposarcomas showed either local recurrence or distant metastasis. All the patients diagnosed with dedifferentiated liposarcomas showed local progression. Burt et al. [3] recommended continuous exploration of aggressive adjuvant treatment in consideration of the high local recurrence rate (64.0%) even after radical resection. Hahn et al. [5] reported that approximately 40% of mediastinal liposarcomas recurred after surgery and multiple successive recurrences were common.
In the present study, 18 (58.1%) patients died of disease progression: 10 died of local recurrence and 8 died of distance metastasis. Our results showed that adjuvant radiotherapy for patients with primary intrathoracic liposarcoma remained controversial. Chan et al. [9] reported that it was essential to completely resect the primary intrathoracic liposarcomas as the radical cure of this disease.
The univariate analyses of the present study revealed associations between that histological subtypes (dedifferentiatied subtype [P = 0.033]) and OS (Additional file 2: Table S2) as well as between initial symptom (chest pain [P = 0.014]) and PFS (Additional file 3: Table S3). On multivariate analysis, histological subtypes (P < 0.05) and initial symptom (P < 0.05) were identified as independent prognostic factors for OS (Additional file 2: Table S2) and PFS (Additional file 3: Table S3). Chen et al. [9] reported that the histological subtype and radical surgery were the influencing factors for OS of patients with primary intrathoracic liposarcoma. The well-differentiated liposarcoma patients who underwent radical surgery had the best prognosis than the patients with other histological subtypes of liposarcoma. Klimstra et al. [2] reported that OS was associated with histological subtype and