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Edited By: Fadlo R. Khuri, MD
About this journal
Cancer, an international interdisciplinary journal of the American Cancer Society, publishes high-impact, peer-reviewed original articles and solicited content on the latest clinical research findings. Each issue of Cancer strives to be comprehensive, spanning the breadth of oncology disciplines and providing something for everyone involved in cancer research, risk reduction, treatment, and patient care.
Highlighted Papers
A phase 1 trial of SGN‐CD70A in patients with CD70‐positive, metastatic renal cell carcinoma
A partial response to SGN‐CD70A is illustrated in a patient who had metastatic renal cell carcinoma.
The role of neuro‐immune interactions in cancer‐related fatigue: Biobehavioral risk factors and mechanisms
The figure highlights key pathways and factors that may influence CRF based on a biobehavioral model.
Large‐scale profiling of serum metabolites in African American and European American patients with bladder cancer reveals metabolic pathways associated with patient survival
Racial disparity–associated metabolic pathways in bladder cancer are shown.
The identification of patient‐specific mutations reveals dual pathway activation in most patients with melanoma and activated receptor tyrosine kinases in BRAF/NRAS wild‐type melanomas
Real‐time polymerase chain reaction analysis of KIT is illustrated for the indicated melanoma samples.
BCR/ABL1–like acute lymphoblastic leukemia: How to diagnose and treat?
Genetics and therapeutic implications for BCR/ABL1–like acute lymphoblastic leukemia.
A clinical trial of intraoperative near‐infrared imaging to assess tumor extent and identify residual disease during anterior mediastinal tumor resection
Indocyanine green accumulation within anterior mediastinal neoplasms generates an NIR signal upon intraoperative fluorescence imaging.
Germline mutations of renal cancer predisposition genes and clinical relevance in Chinese patients with sporadic, early‐onset disease
Analysis of novel FH variants of unknown significance.
Aneuploid acute myeloid leukemia exhibits a signature of genomic alterations in the cell cycle and protein degradation machinery
Frequency and co‐occurrence of CNAs in leukemia‐related genes in (A) euploid acute myeloid leukemia and (B) aneuploid acute myeloid leukemia.
The American Cancer Society (ACS), the Centers for Disease Control and Prevention (CDC), the National Cancer Institute (NCI), and the North American Association of Central Cancer Registries (NAACCR) collaborate to provide annual updates on cancer occurrence and trends in the United States.
The Annual Report to the Nation (ARN) on the Status of Cancer is now available. Click below to access these articles:
CancerScope: Oncology Issues in Focus is a news section that offers readers timely information on events, public policy analysis, topical issues, and personalities.
First Person Profile: Michelle Monje, MD, PhD
Her research on how normal brain functions contribute to pediatric brain tumors may help physicians fight a lethal childhood cancer.
Click here to read this article
Click here to download the PDF
Articles
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Cancer diagnosis and risk of suicide after accounting for prediagnosis psychiatric care: A matched‐cohort study of patients with incident solid‐organ malignancies
- Zachary Klaassen
- Christopher J.D. Wallis
- Thenappan Chandrasekar
- Hanan Goldberg
- Rashid K. Sayyid
- Stephen B. Williams
- Kelvin A. Moses
- Martha K. Terris
- Robert K. Nam
- David Urbach
- Peter C. Austin
- Paul Kurdyak
- Girish S. Kulkarni
- Cancer
- 25 April 2019
Abstract
In this study of 676,470 patients diagnosed with cancer (1 of prostate, breast, colorectal, melanoma, lung, bladder, endometrial, thyroid, kidney, or oral cancer) in Ontario, Canada who are hard matched to 2,152,682 noncancer controls, a cancer diagnosis is associated with a significant increase in the risk of suicidal death. These results are consistent after accounting for prediagnosis utilization of psychiatric care.
National Cancer Institute (NCI) state of the science: Targeted radiosensitizers in colorectal cancer
- Thomas J. George
- Aaron J. Franke
- A. Bapsi Chakravarthy
- Prajnan Das
- Arvind Dasari
- Bassel F. El‐Rayes
- Theodore S. Hong
- Timothy J. Kinsella
- Jerome C. Landry
- James J. Lee
- Arta M. Monjazeb
- Samuel A. Jacobs
- David Raben
- Osama E. Rahma
- Terence M. Williams
- Christina Wu
- C. Norman Coleman
- Bhadrasain Vikram
- Mansoor M. Ahmed
- Cancer
- 24 April 2019
Abstract
This review by the National Cancer Institute’s Radiation Research Program Colorectal Cancer Working Group provides an updated comprehensive examination of the continuously evolving state of the science regarding radiosensitizer drug development in the curative treatment of colorectal cancer. Herein, the authors highlight the available evidence from preclinical models and early‐phase studies, with an emphasis on promising developmental therapeutics undergoing prospective validation in larger scale clinical trials.
Open accessActivating p53 family member TAp63: A novel therapeutic strategy for targeting p53‐altered tumors
- Preethi H. Gunaratne
- Yinghong Pan
- Abhi K. Rao
- Chunru Lin
- Anadulce Hernandez‐Herrera
- Ke Liang
- Antonina S. Rait
- Avinashnarayan Venkatanarayan
- Ashley L. Benham
- Farwah Rubab
- Sang Soo Kim
- Kimal Rajapakshe
- Clara K. Chan
- Lingegowda S. Mangala
- Gabriel Lopez‐Berestein
- Anil K. Sood
- Amy C. Rowat
- Cristian Coarfa
- Kathleen F. Pirollo
- Elsa R. Flores
- Esther H. Chang
- Cancer
- 23 April 2019
Abstract
A new feed‐forward loop is uncovered that involves tumor protein p53 family member TAp63 and its downstream target microRNA 130b (miR‐130b). Injection of miR‐130b using 1,2‐dioleoyl‐sn‐glycero‐3‐phosphocholine liposomes (nontargeted) and a clinically tested, tumor‐targeted nanocomplex (scL) results in significantly decreased tumor burden and improved overall survival, suggesting that the miR‐130b/TAp63 tumor‐suppressor axis could open up novel therapeutic options for many cancers with alterations in the p53 gene and/or pathway.
Phase 1/2 study of fractionated dose lutetium‐177–labeled anti–prostate‐specific membrane antigen monoclonal antibody J591 (177Lu‐J591) for metastatic castration‐resistant prostate cancer
- Scott T. Tagawa
- Shankar Vallabhajosula
- Paul J. Christos
- Yuliya S. Jhanwar
- Jaspreet S. Batra
- Linda Lam
- Joseph Osborne
- Himisha Beltran
- Ana M. Molina
- Stanley J. Goldsmith
- Neil H. Bander
- David M. Nanus
- Cancer
- 23 April 2019
Abstract
Administration of 177Lu‐J591 with dose‐fractionation allows higher cumulative radioactivity dosing. The frequency and depth of prostate‐specific antigen decrease, overall survival, and toxicity (dose‐limiting myelosuppression) increases with higher doses.
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The following is a list of the most cited articles based on citations published in the last three years, according to CrossRef.
more >free accessCongestive heart failure in patients treated with doxorubicin
- Cancer
- 2869-2879
- 19 May 2003
Abstract
This analysis suggests that doxorubicin‐related congestive heart failure (CHF) occurs more frequently and at a lower cumulative dose than previously reported. Left ventricular ejection fraction does not appear to be an accurate predictor of CHF in doxorubicin‐treated patients.
free accessA 5‐decade analysis of 13,715 carcinoid tumors
- Cancer
- 934-959
- 3 February 2003
Abstract
Analysis of the largest known accumulation of carcinoid tumors reveals changing trends in the incidence of these tumors in sites such as the stomach and the appendix. Examination of incidence by race and gender suggests a genetic predisposition for carcinoid tumors at certain sites within certain groups.
free accessAnnual Report to the Nation on the Status of Cancer, 1975‐2012, featuring the increasing incidence of liver cancer
- A. Blythe Ryerson
- Christie R. Eheman
- Sean F. Altekruse
- John W. Ward
- Ahmedin Jemal
- Recinda L. Sherman
- S. Jane Henley
- Deborah Holtzman
- Andrew Lake
- Anne‐Michelle Noone
- Robert N. Anderson
- Jiemin Ma
- Kathleen N. Ly
- Kathleen A. Cronin
- Lynne Penberthy
- Betsy A. Kohler
- Cancer
- 1312-1337
- 9 March 2016
Abstract
The American Cancer Society, the Centers for Disease Control and Prevention, the National Cancer Institute, and the North American Association of Central Cancer Registries collaborate annually to provide updated information about cancer occurrence and trends in the United States. This year's report highlights the increasing burden of liver cancer and emphasizes the importance of public health efforts to prevent, identify, and treat chronic hepatitis B and C viral infections and to promote reductions in other key risk factors for liver cancer.
free accessOsteosarcoma incidence and survival rates from 1973 to 2004
- Cancer
- 1531-1543
- 5 February 2009
Abstract
This comprehensive, population‐based description of osteosarcoma identified important differences in incidence, survival, pathologic subtype, and anatomic site among age groups and quantified the impact of osteosarcoma in Paget disease or as a second cancer on incidence and mortality rates. These findings may have implications for understanding the biology and epidemiology of osteosarcoma.
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Cancer Supplements
Focus on Achievements of the National Center on Reducing Asian American Cancer Health Disparities
Population-Based Cancer Survival in the United States (2001-2009): Findings From the CONCORD-2 Study
European-American Dialogues on Cancer Survivorship: Current Perspectives and Emerging Issues
A Prospective Surveillance Model for Rehabilitation for Women with Breast Cancer
Recent issues
From Dr. Khuri
This commemorative editorial, co-written by Editor-in-Chief Dr. Fadlo Khuri and Dr. Roy S. Herbst, reflects on the transformation that Waun Ki Hong and John Mendelsohn inspired and oversaw as leading allies at the University of Texas MD Anderson Cancer Center.
Read the editorial here:
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More from this Journal
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- Cancer Supplements
- Special Issue: Advances in Melanoma Biology
- 2018 Thank You to Reviewers
- Cancer examines the Affordable Care Act
- Landmarks in History of Cancer
- Survivorship Virtual Issue
- Breast Cancer Awareness Virtual Issue
- CancerScope Articles
- 2015 Top Cited Articles
- Submit to Cancer
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- CME for Reviewers
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