Editor-in-Chief: Douglas S. Clark
Biotechnology and Bioengineering provides an international forum for biotech researchers. As the first biotechnology journal dedicated to the field, our publication has contributed significantly for over sixty years to the advancement of biochemical engineering science.
Biotechnology and Bioengineering publishes Perspectives, Research Articles, Short Communications, and Reviews. Our journal publishes work which has both immediate and future impact on biotechnological processes.
Click here to check out our latest Special Issue on Cell Technologies!
Edited by: Michael J. Betenbaugh and Paula M. Alves
Free to Read for a limited time.
2023 Gaden Award Co-Winners
Each year Biotechnology and Bioengineering sponsors the B&B Gaden Award, highlighting research that reflects exceptional innovation, creativity, and originality. Congratulations to the 2023 co-winners:
J. Christopher Love of the Koch Institute for Integrative Cancer Research at MIT (Top image) and Steven Cramer of Rensselaer Polytechnic Institute (Bottom image).
Read their research here.
Each year Biotechnology and Bioengineering sponsors the B&B Daniel I.C. Wang Award to highlight a younger member of our dynamic community. Congratulations to the 2023 winner Alexander Grünberger of , , Germany.
Click here to read Dr. Grünberger's work at B&B.
To learn more about award eligibility, click here.
Guest Editors:
Matt Croughan, Ph.D.
Tahoe Biotechnology LLC
Reno, Nevada, USA
Gene Schaefer, Sc.D.
The National Institute for Innovation in Manufacturing Biopharmaceuticals (NIIMBL)
Newark, Delaware, USA
Check out the Virtual Issue
Tribute to Daniel I.C. "Danny" Wang
Click here for a retrospective collection honoring Danny Wang, former Editor-in-Chief of Biotechnology & Bioengineering.
Editor's Choice
Biotechnology and Bioengineering honors its Editor's Choice authors. Selected for research excellence, these articles are freely available online for a limited time after publication and are promoted through social media. See the Editor's Choice Article Archive.
Articles
Demonstrating the immunostimulatory and cytokine-augmentation effects of bacterial ghosts on natural killer cells and Caenorhabditis Elegans
- 7 December 2023
Graphical Abstract
Bacterial ghosts (BGs) from Staphylococcus aureus cells were derived through a simple pH-driven culture protocol. In NK-92 cells, the BGs exhibited significant activity as immuno-stimulants and as IL-12 adjuvant, influencing the gene expression of perforin, granzyme-B, Fas-L, and interferon-gamma, signifying heightened NK cell functionality. indicative of enhanced NK cell functionality. Innate response markers viz., lys-2 and ilys-3 were found to be upregulated in Caenorhabditis elegans following the ingestion of BGs, supporting their immuno-modulatory potential in this model organism.
Genomic insights into clostridia in bioenergy production: Comparison of metabolic capabilities and evolutionary relationships
- 4 December 2023
Graphical Abstract
Evolutionary timeline and shared metabolic features of bacteria from diverse genera, including Acetivibrio, Bacillus, Cellulosilyticum, Clostridium, Desulfotomaculum, Lachnoclostridium, Moorella, Ruminiclostridium, and Thermoanaerobacterium, for bioenergy and related applications.
Hypersecretory production of glucose oxidase in Pichia pastoris through combinatorial engineering of protein properties, synthesis, and secretion
- 1 December 2023
Graphical Abstract
Metabolic regulatory network kinetic modeling with multiple isotopic tracers for iPSCs
- 1 December 2023
Hyperthermic shift and cell engineering increase small extracellular vesicle production in HEK293F cells
- 1 December 2023
CFD‐based bioreactor model with proportional–integral–derivative controller functionality for dissolved oxygen and pH
- 30 November 2023
Brain organoids: A revolutionary tool for modeling neurological disorders and development of therapeutics
- 28 November 2023
Genome‐wide CRISPR/Cas9 knockout screening to mitigate cell growth inhibition induced by histone deacetylase inhibitors in recombinant CHO cells
- 28 November 2023
Graphical Abstract
Histone deacetylase inhibitors, such as CI994, enhance therapeutic protein production, but hinder cell proliferation in recombinant CHO cell cultures. Here, knockout target genes conferring CI994 resistance were identified via virus-free genome-wide clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 knockout cell library. These target genes were subsequently validated through knockout experiments.
The following is a list of the most cited articles based on citations published in the last three years, according to CrossRef.
Microalgae for oil: Strain selection, induction of lipid synthesis and outdoor mass cultivation in a low‐cost photobioreactor
- 100-112
- 18 June 2008
Nanocomposite hydrogels for biomedical applications
- 441-453
- 22 November 2013
Recent Issues
IssueVolume 120, Issue 9Advanced Cell Technologies
i, 2379-2770September 2023Michael J. Betenbaugh, Paula M. Alves
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