The Journal of Cellular Physiology examines eukaryotic cell biology and physiology. Our journal focuses on articles that adopt a molecular mechanistic approach to investigate cell structure and function using cellular, biochemical, molecular, genetic, genomic, proteomic and bioinformatic approaches.

All our articles have a clear hypothesis and present novel and significant findings. We offer free format submission making initial submission easy.

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Publishing reports of high biological significance in eukaryotic cell biology and physiology, with focus on a molecular mechanistic approach to investigate cell structure and function, let Journal of Cellular Physiology help you achieve impact.

Read the full Aims and Scope here.

It is strongly recommended to carefully read and follow the Author Guidelines before submitting a manuscript. Access the Author Guidelines here.

 

Articles

RESEARCH ARTICLE
Open access

SMC2 and Condensin II Subunits Are Essential for the Development of Hematopoietic Stem and Progenitor Cells in Zebrafish

Chang-Kyu Oh, Man S. Kim, Unbeom Shin, Ji Wan Kang, Yun Hak Kim, Hwa Soo Ko, Jae Sun Ra, Soyul Ahn, Eun Young Choi, Sanghyeon Yu, Uijeong Nam, Taesoo Choi, Kyungjae Myung, Yoonsung Lee, 
  •  25 March 2025
RESEARCH ARTICLE

Cardiomyocytic FoxP3 Attenuates Expression of β Isoform of Myosin Heavy Chain During Cardiac Hypertrophy and Effects of Triptolide

Jia-Hui Hong, Xi-Chun Pan, Ya-Lan Xiong, Peng Wang, Yao Yuan, Ya Liu, Hai-Gang Zhang, 
  •  24 March 2025

Graphical Abstract

Cardiomyocytic FoxP3 Attenuates Expression of β Isoform of Myosin Heavy Chain During Cardiac Hypertrophy and Effects of Triptolide Issue 3, 2025

Cardiomyocytic FoxP3 exerts protective function during cardiac hypertrophy. By suppressing transcription of β-MHC and interfering with the function of NFATc3, FoxP3 downregulates the expression of hypertrophic-related genes (e.g., ANP, BNP, and β-MHC). The bioactive natural product, triptolide, can reverse cardiac hypertrophy by increasing the expression of cardiomyocytic FoxP3.

ISSUE INFORMATION
free access

Issue Information

  •  11 March 2025
RESEARCH ARTICLE

Daytime-Restricted Feeding Alleviates D-Galactose-Induced Aging in Mice and Regulates the AMPK and mTORC1 Activities

Tiepeng Li, Ning Huang, Honghan Chen, Yu Yang, Jian Zhang, Weitong Xu, Hui Gong, Chuhui Gong, Ming Yang, Tingting Zhao, Fangfang Wang, Hengyi Xiao, 
  •  11 March 2025
RESEARCH ARTICLE

Trophic Factors in Muscle‐Nerve Cross‐Talk Signaling Augment Muscle Fiber and Motor Endplate Development

James T. Redden, Sophie Kothe, David J. Cohen, Zvi Schwartz, Michael J. McClure, 
  •  23 February 2025
RESEARCH ARTICLE

Comparative Single‐Cell Analysis Reveals Tendon Progenitor Dysfunction by Age‐Associated Oxidative Stress and Its Restoration by Antioxidant Treatments

Youngjae Jeong, Dongwook Yang, Jea Giezl Solidum, Laura Ortinau, Dongsu Park, 
  •  23 February 2025
RESEARCH ARTICLE

Role of Metabolic Sensor GPR81/HCAR1 in Diabetic Podocytes: Downregulated Lipolysis Results in the Deterioration of Glomerular Filtration Barrier

Klaudia Grochowalska, Maria Szrejder, Patrycja Rachubik, Irena Audzeyenka, Dorota Rogacka, Magdalena Narajczyk, Agnieszka Piwkowska, 
  •  17 February 2025

Graphical Abstract

Role of Metabolic Sensor GPR81/HCAR1 in Diabetic Podocytes: Downregulated Lipolysis Results in the Deterioration of Glomerular Filtration Barrier Issue 2, 2025

Primary rat podocytes cultured in hyperglycemic conditions showed lipolysis inhibition, which was triggered by GPR81 activation. Lipolysis inhibition resulted in rearrangement of actin cytoskeleton, accumulation of lipid droplets, and enhanced permeability of podocyte monolayer to albumin.

RESEARCH ARTICLE

Single-Cell Transcriptome Decoding Umbilical Cord-Derived Mesenchymal Stem Cell Heterogeneity Reveals a Unique IL1R1HighPDGFRAHigh Ultroser-G-MSC With Osteogenesis and Chondrogenesis Signatures

Shihao Huang, Xinyu Xu, Jiaqi Guo, Zhuolan Li, Yanlin Wu, Yuanyuan Liu, Qinyi Sun, Sihan Wang, Huilin Yan, Yueyan Su, Wei Guo, 
  •  16 February 2025

Graphical Abstract

Single-Cell Transcriptome Decoding Umbilical Cord-Derived Mesenchymal Stem Cell Heterogeneity Reveals a Unique IL1R1HighPDGFRAHigh Ultroser-G-MSC With Osteogenesis and Chondrogenesis Signatures Issue 2, 2025

The heterogeneity of umbilical cord mesenchymal stem cells (UC-MSCs) caused by different culture systems hampers clinical application. The authors map a comprehensive single-cell transcriptome atlas to decipher the heterogeneity of hUC-MSC in different culture systems, revealing a unique IL1R1highPDGFRAhigh Ultroser-G-MSC subgroups that have better efficacy in the treatment of osteoarthritis (OA), providing a more targeted method for the treatment of OA. (Created with BioRender.com)

RESEARCH ARTICLE

Stearoyl‐CoA Desaturase 1 Regulates Metabolism and Inflammation in Mouse Perivascular Adipose Tissue in Response to a High‐Fat Diet

Adrian Sowka, Volodymyr V. Balatskyi, Viktor O. Navrulin, James M. Ntambi, Pawel Dobrzyn, 
  •  12 February 2025
REVIEW ARTICLE

Molecular Mechanisms and Therapeutic Implications of Long Non‐coding RNAs in Cutaneous Biology and Disease

Alessandro Zuccotti, Farah Al-Fatyan, Giulia D. S. Ferretti, Irene Bertolini, David T. Long, Ozgur Sahin, Jezabel Rodriguez-Blanco, Thibaut Barnoud, 
  •  12 February 2025
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