The Journal of Cellular Physiology examines eukaryotic cell biology and physiology. Our journal focuses on articles that adopt a molecular mechanistic approach to investigate cell structure and function using cellular, biochemical, molecular, genetic, genomic, proteomic and bioinformatic approaches.

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RESEARCH ARTICLE

Cardiomyocytic FoxP3 Attenuates Expression of β Isoform of Myosin Heavy Chain During Cardiac Hypertrophy and Effects of Triptolide

  •  24 March 2025

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Cardiomyocytic FoxP3 Attenuates Expression of β Isoform of Myosin Heavy Chain During Cardiac Hypertrophy and Effects of Triptolide Issue 3, 2025

Cardiomyocytic FoxP3 exerts protective function during cardiac hypertrophy. By suppressing transcription of β-MHC and interfering with the function of NFATc3, FoxP3 downregulates the expression of hypertrophic-related genes (e.g., ANP, BNP, and β-MHC). The bioactive natural product, triptolide, can reverse cardiac hypertrophy by increasing the expression of cardiomyocytic FoxP3.

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  •  11 March 2025
RESEARCH ARTICLE

Role of Metabolic Sensor GPR81/HCAR1 in Diabetic Podocytes: Downregulated Lipolysis Results in the Deterioration of Glomerular Filtration Barrier

  •  17 February 2025

Graphical Abstract

Role of Metabolic Sensor GPR81/HCAR1 in Diabetic Podocytes: Downregulated Lipolysis Results in the Deterioration of Glomerular Filtration Barrier Issue 2, 2025

Primary rat podocytes cultured in hyperglycemic conditions showed lipolysis inhibition, which was triggered by GPR81 activation. Lipolysis inhibition resulted in rearrangement of actin cytoskeleton, accumulation of lipid droplets, and enhanced permeability of podocyte monolayer to albumin.

RESEARCH ARTICLE

Single-Cell Transcriptome Decoding Umbilical Cord-Derived Mesenchymal Stem Cell Heterogeneity Reveals a Unique IL1R1HighPDGFRAHigh Ultroser-G-MSC With Osteogenesis and Chondrogenesis Signatures

  •  16 February 2025

Graphical Abstract

Single-Cell Transcriptome Decoding Umbilical Cord-Derived Mesenchymal Stem Cell Heterogeneity Reveals a Unique IL1R1HighPDGFRAHigh Ultroser-G-MSC With Osteogenesis and Chondrogenesis Signatures Issue 2, 2025

The heterogeneity of umbilical cord mesenchymal stem cells (UC-MSCs) caused by different culture systems hampers clinical application. The authors map a comprehensive single-cell transcriptome atlas to decipher the heterogeneity of hUC-MSC in different culture systems, revealing a unique IL1R1highPDGFRAhigh Ultroser-G-MSC subgroups that have better efficacy in the treatment of osteoarthritis (OA), providing a more targeted method for the treatment of OA. (Created with BioRender.com)

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