Edited By: Rong Fu
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Articles
Evaluation of the fully automated urine particle analyzer UF‐1500
- 2 December 2023
Graphical Abstract
The novel and compact model of the fully automated urine particle analyzer UF-1500 was evaluated. The performance of the UF-1500 is comparable to that of the existing UF-5000 analyzer. The UF-1500 was suitable to be introduced in clinical practice, but a manual microscopic examination is necessary for the samples with false-positive or false-negative results.
Performance evaluation of sperm concentration, motility, and morphological analysis for GSA-810 series of sperm quality analysis system
- 27 November 2023
Graphical Abstract
The GSA-810 system can accurately detect sperm concentration in semen samples with sperm concentrations in the range of (2–100) × 106/mL. Semen samples with a sperm concentration between 50 × 106/mL and 100 × 106/mL can be directly detected using the GSA-810 system without dilution. The higher the sperm concentration and PR, the better the repeatability of the detection results.
A novel cuproptosis‐related prognostic gene signature in adrenocortical carcinoma
- 23 November 2023
Graphical Abstract
Validation of independent prognostic factors of the cuproptosis-related risk score (CRRS) using a survival curve and a time-dependent ROC (A). CDKN2A and FDX1 expressions were independent prognostic predictors of ACC patients, and low expression of CDKN2A (B) and FDX1 (C) was associated with better survival outcomes.
Cell-free DNA extraction from urine of lung cancer patients and healthy individuals: Evaluation of a simple method using sample volume up-scaling
- 22 November 2023
Graphical Abstract
Only at alkaline pH levels EDTA is a reliable preservative for cfDNA in urine. Moreover, it was found that urine volume up-scaling (>5 mL) is mandatory if the mutation allele frequency is less than 1%. A similar amount of small-sized cfDNA targets were detected in three different gene sites indicating a non-random distribution pattern across genes.
Application of the cell-based RT-qPCR assay (C-QPA) for potency detection of the novel trivalent rotavirus vaccine in China
- 17 November 2023
Graphical Abstract
The linear range of C-QPA. The correlation coefficients (R2) of the three strains ranged from 0.97 to 0.98, indicating a good linearity between the UIs and the dilutions. According to the linear regression analysis, the linear range of the assay for G2 (LD9, red line), G3 (LS4/9, green line) and G4 (LH9, blue line) was 2.0–6.5, 3.9–8.3 and 3.5–8.1 UI, respectively.
Cryptic exon activation caused by a novel deep‐intronic splice‐altering variant in Becker muscular dystrophy
- 15 November 2023
Graphical Abstract
Our study successfully identified a novel deep-intronic splice-altering variant in DMD via the combined application of dystrophin mRNA analysis, genomic Sanger sequencing, and in silico bioinformatic analyses. The novel deep-intronic variant (c.8217 + 23338A > G) resulted in the activation of a new dystrophin cryptic exon, which confirmed the genetic diagnosis of dystrophinopathy in our patient.
Combinational antibody detection approach increases the clinical validity of colorectal cancer screening
- 14 November 2023
Graphical Abstract
The AUC values increased in the combined ROC analysis compared with the individual ROC analysis. Using a combination antibody detection approach of tumor markers for CRC diagnosis has the potential to be an effective approach. Therefore, the use of serum protein biomarkers holds promise for the development of inexpensive, noninvasive, and inexpensive tests for the detection of CRC.
Expanding phenotype heterogeneity of NARS2 by presenting subdural hematoma and parenchymal hemorrhage
- 10 November 2023
Graphical Abstract
Summarized view of phenotypic and genetic findings of two patients carrying c.500A > G variant in NARS2.
SNHG1/miR‐21 axis mediates the cardioprotective role of aloin in sepsis through modulating cardiac cell viability and inflammatory responses
- 10 November 2023
Graphical Abstract
(A,B) The myocardial damage markers cTnI and BNP were increased by CLP in mice, but was reduced by aloin treatment in CLP-treated mice model. (C,D) CLP treatment had inhibitory effects on LVEF and +dp/dtmax, and had promotion effects on –dp/dtmax, but aloin alleviated these effects. (E,F) CLP treatment increased the levels of IL-1β and TNF-α in mice, and the effects of CLP on mice were alleviated by aloin. **p < 0.01, ***p < 0.001 versus Sham group; ##p < 0.01, ###p < 0.001 versus CLP group. BNP, brain natriuretic peptide; CLP, cecal ligation and puncture; cTnI, cardiac troponin I; IL-1β, interleukin 1β; LVEF, left ventricular ejection fraction; TNF-α, tumor necrosis factor alpha.
Serum creatinine phosphokinase: A potential prognostic marker in assessing clinical severity with organophosphorus poisoning
- 31 October 2023
Graphical Abstract
Serum creatinine phosphokinase (CPK) and its prognostic significance in OPC poisoning.
An overview on inactivated and live‐attenuated SARS‐CoV‐2 vaccines
- Journal of Clinical Laboratory Analysis
- 14 April 2022
Graphical Abstract
SARS-CoV-2 virus enters the body and replicates inside the cells. COVID-19 is ingested by an antigen presenting cells like dendritic cells. Afterward, the antigen is recognized by Th cells that recruit other immune cells for infection control. B cells produce specific antibody against COVID-19 and cytotoxic T cells destroy the cell infected by virus. Finally, some B and T cells remain in the body for immunological memory.
Necroptosis‐related lncRNA to establish novel prognostic signature and predict the immunotherapy response in breast cancer
- Journal of Clinical Laboratory Analysis
- 1 March 2022
Graphical Abstract
Seven necroptosis-related lncRNAs, SH3BP5-AS1, AC012073.1, AC120114.1, LINC00377, AL133467.1, AC036108.3, and AC020663.2 were involved in the risk model. In addition, the forecast performance of this model was verified and accredited. Most notably, the patients of higher risk score were characterized with increased TMB and decreased TIDE score, indicating that these patients showed better immune checkpoint blockade response.
Obesity and gut–microbiota–brain axis: A narrative review
- Journal of Clinical Laboratory Analysis
- 14 April 2022
Graphical Abstract
Gut microbiota is a complex system of organisms, mainly different bacterial species, the gut microbiota interacts with the host, affects host systems and organs (e.g. the brain) and modulates the host physiological functions. The interaction between the gut microbiota and the brain, famously known as gut-brain axis is a bidirectional connection via neural, immune, and endocrine pathways.
Circulating microRNAs as predictive biomarkers of coronary artery diseases in type 2 diabetes patients
- Journal of Clinical Laboratory Analysis
- 29 March 2022
Graphical Abstract
There is a considerable number of miRNAs in T2DM leading to CAD and its complications. Furthermore, miRNAs represent potential novel therapeutic targets for several cardiovascular disorders. This study provided an overview of the alterations in circulatory miRNAs in T2DM and various CADs.
Neurological manifestations in patients with COVID‐19: A systematic review and meta‐analysis
- Journal of Clinical Laboratory Analysis
- 6 April 2022
Graphical Abstract
A total of 4455 studies were collected from PubMed/Medline, Embase, and Web of Science databases. After the removal of duplicates, articles were screened for title and abstract, and 119 papers met the criteria. Thereafter, the full-text of these studies, which all reported the neurological symptoms of COVID-19 infection, were evaluated. Following the exclusion of irrelevant studies, 20 articles were identified as qualified for final extraction and analysis.
Antibiotic resistance: The challenges and some emerging strategies for tackling a global menace
- Journal of Clinical Laboratory Analysis
- 10 August 2022
Graphical Abstract
Immuno-antibiotics inhibit the non-mevalonate or methyl-D-erythritol phosphate (MEP) pathway of isoprenoid biosynthesis and riboflavin biosynthesis pathway in bacteria. This image was created with BioRender (https://biorender.com/).
COVID‐19 in HIV‐positive patients: A systematic review of case reports and case series
- Journal of Clinical Laboratory Analysis
- 20 February 2022
Graphical Abstract
Outcomes of patients with HIV and COVID-19 co-infection.
Comorbidities and mortality rate in COVID‐19 patients with hematological malignancies: A systematic review and meta‐analysis
- Journal of Clinical Laboratory Analysis
- 6 April 2022
Graphical Abstract
Initially, a total of 1169 articles were collected from databases. After removing the duplicates, 704 studies remained. In the screening phase, 548 of them were excluded through the title and abstract evaluation. Out of these studies, 53 met the inclusion pellucid criteria based on the full text screening. At the final stage, 15 eligible articles were included in the meta-analysis.
A novel prognostic model associated with the overall survival in patients with breast cancer based on lipid metabolism‐related long noncoding RNAs
- Journal of Clinical Laboratory Analysis
- 20 April 2022
Graphical Abstract
(A) Kaplan–Meier curve of samples in high-risk group and low-risk groups in validation set. (B) Distribution of risk score in validation set. (C) The relationship between survival status and risk score in validation set. (D) Forest plot of Cox univariate analysis in validation set. (E) Forest plot of Cox multivariate analysis in validation set. (F) ROC curve of risk score and clinical features in validation set.
High serum exosomal long non‐coding RNA DANCR expression confers poor prognosis in patients with breast cancer
- Journal of Clinical Laboratory Analysis
- 11 February 2022
Graphical Abstract
Receiver operating characteristic curves of single and combining three markers with the optimum cut-off values in differentiating BC from controls.
Differential identification of urine crystals with morphologic characteristics and solubility test
- Journal of Clinical Laboratory Analysis
- 26 September 2022
Antibiotic resistance: The challenges and some emerging strategies for tackling a global menace
- Journal of Clinical Laboratory Analysis
- 10 August 2022
Obesity and gut–microbiota–brain axis: A narrative review
- Journal of Clinical Laboratory Analysis
- 14 April 2022
Mechanism of action, resistance, synergism, and clinical implications of azithromycin
- Journal of Clinical Laboratory Analysis
- 21 April 2022
Malaria diagnostic update: From conventional to advanced method
- Journal of Clinical Laboratory Analysis
- 4 March 2022
The correlation of D‐dimer to stroke diagnosis within 24 hours: A meta‐analysis
- Journal of Clinical Laboratory Analysis
- 4 February 2022
Clinical application of low erythrocyte sedimentation rate/high C‐reactive protein to antineutrophil cytoplasmic antibody‐associated vasculitis
- Journal of Clinical Laboratory Analysis
- 8 January 2022
An overview on inactivated and live‐attenuated SARS‐CoV‐2 vaccines
- Journal of Clinical Laboratory Analysis
- 14 April 2022
