In this study, based on the confirmation of ACE2 receptor expression in salivary glands through database analysis, it was assumed and confirmed that RNA of SARS-COV-2 could be detected in saliva samples. At the same time, we also clinically observed that the initial oral-related symptoms of SARS-COV-2 infection may be amblygeustia and dry mouth.

A Lianhua Qingwen capsule (LQC) target and COVID-19 related gene set is established to construct compound-target pharmacology network. Gene ontology and Kyoto Encyclopedia of Genes and Genomes analysis indicate the regulating effect of LQC on apoptosis, antivirus, immune defense, and inflammatory response. Protein-protein interaction network and critical subnetworks are constructed to identify hub gene target. The most significant gene, Akt 1, is selected to perform molecular docking with active compounds of LQC. Six compounds are finally recognized as potential anti-COVID-19 agents.

The potential mechanisms of MSCs therapy for COVID-19. MSCs have great therapeutic potential in immunomodulation and tissue repair through secretion of soluble paracrine protein factors and exosomes. MSCs can regulate the functions of a variety of immune cells, secrete several cytokines, promote tissue repair and regeneration, and may play important therapeutic roles in patients with COVID-19. MSCs: mesenchymal stem cells; HGF, hepatocyte growth factor; VEGF, vascular endothelial growth factor; KGF, keratinocyte growth factor; FGF, fibroblast growth factor; TGF-β, transforming growth factor-β; TNF-α, tumor necrosis factor-α; MSC-exo, exosomes.

We investigated the safety, feasibility and clinical efficacy of Umbilical Cord Mesenchymal Stem Cells (UC-MSCs) transplantation in severe and critically severe COVID-19 patients. The transplantation of UC-MSCs was safe and feasible. The oxygenation index and radiological presentations were improved. Lymphocyte and its subset counts were recovered.

This review describes the mechanisms whereby exosomes (EXOs) derived from adipose-derived stem cells (ADSCs) regulate wound healing and their clinical application. In the wound, ADSCs-EXOs modulate immune responses and inflammation, promote angiogenesis, accelerate proliferation and re-epithelization of skin cells and regulate collagen remodelling, which inhibits scar hyperplasia. ADSCs-EXOs have the potential to be used in the clinic, as they can improve fat grafting, promote wound healing of diabetic patients and act as a carrier and combined scaffold for treatment, leading to scarless cutaneous repair.

Propofol inhibits tumor cell proliferation, metastasis, and promotes cell apoptosis and increases the sensitivity to chemotherapeutic drugs. In addition, in vivo animal models have shown that propofol inhibits tumor growth and metastasis. Furthermore, propofol is associated with better survival outcomes in cancer patients after surgery.

tsRNAs are generated under stress condition which are functional molecules. Due to their regulatory mechanism in regulating mRNA stability, transcription, ribosomal RNA (rRNA) synthesis and RNA reverse transcription, tsRNAs are significantly involved in the cellular function, including cell proliferation, migration, cell cycle and apoptosis, as well as the occurrence and development of a variety of diseases.

This review describes the mechanisms whereby exosomes (EXOs) derived from adipose-derived stem cells (ADSCs) regulate wound healing and their clinical application. In the wound, ADSCs-EXOs modulate immune responses and inflammation, promote angiogenesis, accelerate proliferation and re-epithelization of skin cells and regulate collagen remodelling, which inhibits scar hyperplasia. ADSCs-EXOs have the potential to be used in the clinic, as they can improve fat grafting, promote wound healing of diabetic patients and act as a carrier and combined scaffold for treatment, leading to scarless cutaneous repair.

The potential mechanisms of MSCs therapy for COVID-19. MSCs have great therapeutic potential in immunomodulation and tissue repair through secretion of soluble paracrine protein factors and exosomes. MSCs can regulate the functions of a variety of immune cells, secrete several cytokines, promote tissue repair and regeneration, and may play important therapeutic roles in patients with COVID-19. MSCs: mesenchymal stem cells; HGF, hepatocyte growth factor; VEGF, vascular endothelial growth factor; KGF, keratinocyte growth factor; FGF, fibroblast growth factor; TGF-β, transforming growth factor-β; TNF-α, tumor necrosis factor-α; MSC-exo, exosomes.

Osteoporosis occurs when the orchestrated balance between bone formation by osteoblasts and bone destruction by osteoclasts breaks down, and this process is closely associated with MSCs. Existing preclinical evidences of MSCs derived from different tissues support MSCs-based cell therapy as a possible radical approach to the prevention and treatment of osteoporosis. Clinical trials of MSC transplantation for osteoporosis mainly focus on the application of autologous cells and will fill the gap of clinical data.

A Lianhua Qingwen capsule (LQC) target and COVID-19 related gene set is established to construct compound-target pharmacology network. Gene ontology and Kyoto Encyclopedia of Genes and Genomes analysis indicate the regulating effect of LQC on apoptosis, antivirus, immune defense, and inflammatory response. Protein-protein interaction network and critical subnetworks are constructed to identify hub gene target. The most significant gene, Akt 1, is selected to perform molecular docking with active compounds of LQC. Six compounds are finally recognized as potential anti-COVID-19 agents.

In current review, we accumulated literature to the understanding of lncRNAs biogenesis and function, as well as the latest findings of novel lncRNAs-based therapeutics in TNBC. We also present the current state of knowledge concerning the expression and regulation of lncRNAs in TNBC, and discuss the future development of lncRNA-based strategies for clinical TNBC patients.

Sorafenib triggers hepatic stellate cell ferroptosis by inhibiting the HIF-1α/SLC7A11 pathway to attenuate liver fibrosis. Treatment with sorafenib induces a decrease of HIF-1α, which in turn reduces SLC7A11 expression in HSCs. Then leads to GPX4, GSH depletion and ROS excess, and ultimately induces HSC ferroptosis and ECM reduction.

Signal transducer and activator of transcription 3 (STAT3) is a member of the STAT protein family, vitally important for eukaryotic cells. We review the molecular structure and function of STAT3 and its isoforms, highlighting signalling pathways for the regulation of gene transcription. A critical appraisal of STAT3 in cancers, such as osteosarcoma, is provided emphasizing potential therapeutic approaches targeting STAT3 and its inhibitors

In this study, based on the confirmation of ACE2 receptor expression in salivary glands through database analysis, it was assumed and confirmed that RNA of SARS-COV-2 could be detected in saliva samples. At the same time, we also clinically observed that the initial oral-related symptoms of SARS-COV-2 infection may be amblygeustia and dry mouth.

D-Mannose effectively alleviates osteoarthritis progression by suppressing cartilage degeneration. D-mannose protects osteoarthritic chondrocytes by attenuating sensitivity to ferroptosis. HIF-2α is vital in potentiating the susceptibility of chondrocytes to ferroptosis. HIF-2α is a central mediator in D-mannose-induced ferroptosis resistance.