Cell Proliferation is an open access cell biology journal publishing research in all aspects of cell proliferation and differentiation in normal and abnormal states. We welcome submissions regarding stem cells, regenerative medicine, tissue engineering, cell cycle control, cell senescence, cell death, and mathematical modelling. The journal is considered essential reading for those involved in cancer research and stem cell research.

We publish original research papers and invited review articles and letters commenting on previously published papers and/or topics of general interest.

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  • Open access publishing maximizes your audience, article downloads and citations, and increases the overall impact of your work.
  • Fast first decision within 5 days from submission (median).
  • The flagship journal of the Chinese Society for Stem Cell Research published with the Beijing Institute for Stem Cell and Regenerative Medicine.
  • A global research profile: Indexed by EBSCO, Embase, PubMed, Science Citation Index, BIOSIS, and more!
  • Regular thematic collections make research in specific areas easy to find.
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Articles

ORIGINAL ARTICLE
Open access

PD-L1 Promotes Immunological Tolerance and Enhances Visual Protection of hESC-RPE Grafts in Retinal Degeneration

  •  14 February 2025

Graphical Abstract

PD-L1 Promotes Immunological Tolerance and Enhances Visual Protection of hESC-RPE Grafts in Retinal Degeneration Issue ,

We generated immune-tolerant mature hESC-RPE cells by overexpressing PD-L1. PD-L1-expressing hESC-RPE grafts exhibited significantly higher survival, reduced apoptosis and enhanced visual protection in retinal degeneration models, which presents an alternative target to improve the efficiency of hESC-RPE-based therapy for AMD.

REVIEW
Open access

The Application of Polymeric Nanoparticles as Drug Delivery Carriers to Cells in Neurodegenerative Diseases

  •  11 February 2025

Graphical Abstract

The Application of Polymeric Nanoparticles as Drug Delivery Carriers to Cells in Neurodegenerative Diseases Issue ,

Polymeric nanoparticles represent promising drug (gene) delivery carriers to the brain due to their unique advantages to facilitate the penetration of blood–brain barrier and endocytosis of neuronal cells in neurodegenerative diseases.

ORIGINAL ARTICLE
Open access

Klotho Regulates Club Cell Senescence and Differentiation in Chronic Obstructive Pulmonary Disease

  •  10 February 2025

Graphical Abstract

Klotho Regulates Club Cell Senescence and Differentiation in Chronic Obstructive Pulmonary Disease Issue ,

We speculated lack of Klotho (KL) would aggravate club cell senescence, which contributes to COPD inflammation. In this study, we collected chronic obstructive pulmonary disease (COPD) lung tissue using single-cell RNA sequencing (scRNA-seq), revealing club cell heterogeneity and cellular senescence in COPD. Club cells were divided into four subpopulations, in addition, KL and club cell secretory proteins (CCSP) were downregulated in cigarette smoke (CS)-induced COPD mice, associated with increasing age-related markers. After KL knockout, more ciliated cells appeared where club cells disappeared, and resulting CCSP downregulation. Furthermore, KL deficiency aggravated club cell senescence and CSE-induced pulmonary inflammation. To investigate the specific regulation mechanism, hnRNPA2/B1 was recognised and identified it was the key molecule in KL-regulated club cell senescence, and neddylation of club cell was a crucial factor contributing to hnRNPA2/B1 downregulation. Thus, we concluded that KL could regulate club cell senescence and differentiation. When CS stimulates the small airway epithelium, KL deficiency aggravates lung inflammation, club cell senescence and dysfunctional of ciliated cell. Targeting neddylation might be a promising strategy to reverse lung aging and club cell senescence. This study describes a novel mechanism about COPD-linked lung inflammation.

ORIGINAL ARTICLE
Open access

Large-Scale Production of Expandable Hepatoblast Organoids and Polarised Hepatocyte Organoids From hESCs Under 3D Static and Dynamic Suspension Conditions

  •  8 February 2025

Graphical Abstract

Large-Scale Production of Expandable Hepatoblast Organoids and Polarised Hepatocyte Organoids From hESCs Under 3D Static and Dynamic Suspension Conditions Issue ,

Under 3D suspension culture condition, the expandable hepatoblast organoids and mature polarised hepatocyte organoids were established by low concentration of Matrigel from human embryonic stem cells, which recapitulated the gene expression signatures and functions of primary human hepatoblast and hepatocytes. The dynamic culture system by using bioreactors further enlarged the scale of hepatocyte organoid culture.

ORIGINAL ARTICLE
Open access

Ciliary IFT-B Transportation Plays an Important Role in Human Endometrial Receptivity Establishment and is Disrupted in Recurrent Implantation Failure Patients

  •  6 February 2025

Graphical Abstract

Ciliary IFT-B Transportation Plays an Important Role in Human Endometrial Receptivity Establishment and is Disrupted in Recurrent Implantation Failure Patients Issue ,

Our results suggested that mitochondria-accelerated motile cilia intraflagellar transport may be involved in endometrial microenvironment establishment.

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