Clinical & Experimental Allergy is the official Journal of the British Society for Allergy & Clinical Immunology, publishing clinical and experimental observations in disease in all fields of medicine in which allergic hypersensitivity plays a part. Clinical & Experimental Allergy strikes an excellent balance between clinical and scientific articles and carries regular reviews and editorials written by leading authorities in their field.

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Featured Cover
The cover image is based on the Research Letter Diet diversity in pregnancy and early allergic manifestations in the offspring by Stina Bodén et al., https://doi.org/10.1111/cea.14346.
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The cover image is based on the Review Article Formula milk companies and allergy healthcare professionals in India by Hilary Allen et al., https://doi.org/10.1111/cea.14355.
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The cover image is based on the Original Article Ara h 2-specific IgE epitope-like peptides inhibit the binding of IgE to Ara h 2 and suppress lgE-dependent effector cell activation by Peter Korošec et al., https://doi.org/10.1111/cea.14314.
Featured Cover
The cover image is based on the Original Article Ara h 2-specific IgE epitope-like peptides inhibit the binding of IgE to Ara h 2 and suppress lgE-dependent effector cell activation by Peter Korošec et al., https://doi.org/10.1111/cea.14314.
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Articles

COCHRANE CORNER
free access

Cochrane Corner: Pharmacological Treatment of Gastro‐Oesophageal Reflux in Children

Aahil Damani, Nabeela Bhaloo, 
  •  10 October 2024
RESEARCH LETTER

Cluster Analysis Identifies Patients With Severe Eosinophilic Asthma Who Achieve Super‐Response and Remission With Mepolizumab

Danilo Di Bona, Massimo Bilancia, Claudia Crimi, Michelina Daddato, Alida Benfante, Maria Filomena Caiaffa, Cecilia Calabrese, Raffaele Campisi, Santi Nolasco, Giovanna Elisiana Carpagnano, Maria D'Amato, Corrado Pelaia, Girolamo Pelaia, Angelantonio Maglio, Nicola Scichilone, Giulia Scioscia, Giuseppe Spadaro, Massimo Triggiani, Isabella Carrieri, Giuseppe Valenti, Alessandro Vatrella, Luigi Macchia, Nunzio Crimi, 
  •  10 October 2024

Graphical Abstract

Cluster Analysis Identifies Patients With Severe Eosinophilic Asthma Who Achieve Super-Response and Remission With Mepolizumab Issue ,

This study identifies two distinct subgroups of patients with severe eosinophilic asthma who respond differently to mepolizumab. Cluster analysis reveals that patients with a family history of asthma, positive skin prick tests and higher baseline lung function have better treatment outcomes, highlighting the value of personalised treatment strategies.

REVIEW ARTICLE
Open access

Adrenaline Auto‐Injectors for Preventing Fatal Anaphylaxis

Marcus Sim, Vibha Sharma, Karen Li, Mary H. Gowland, Tomaz Garcez, Cassandra Shilladay, Richard Pumphrey, Nandinee Patel, Paul J. Turner, Robert J. Boyle, 
  •  9 October 2024

Graphical Abstract

Adrenaline Auto-Injectors for Preventing Fatal Anaphylaxis Issue ,

During 35 years of increasing Adrenaline Autoinjector prescribing, there has been no obvious reduction in numbers of fatal anaphylaxis cases. Animal and human studies suggest intravenous adrenaline infusion, with appropriate fluid resuscitation, prevents fatal anaphylaxis. Current Adrenaline Autoinjectors may have little impact on rates of fatal anaphylaxis due to a lack of sustained and sufficient plasma adrenaline concentration.

RESEARCH LETTER
Open access

Anaphylaxis Management in Paediatric Patients Undergoing Milk Oral Immunotherapy

Dimitry Buyansky, Roy Khalaf, Sofianne Gabrielli, Julia Upton, Eyal Grunebaum, Edmond S. Chan, Ingrid Baerg, Liane Beaudette, Danbing Ke, Bruce Mazer, Christine McCusker, Duncan Lejtenyi, Moshe Ben-Shoshan, 
  •  9 October 2024
ABSTRACT

British Society for Allergy and Immunology Abstracts From the 2024 Annual Conference

  •  7 October 2024
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Articles with the most citations published in the Last 2 Years according to CrossRef. The citation counts listed reflect the total number of all citations to date.

Open access

Trends in eczema prevalence in children and adolescents: A Global Asthma Network Phase I Study

Sinéad Máire Langan, Amy R. Mulick, Charlotte E. Rutter, Richard J. Silverwood, Innes Asher, Luis García-Marcos, Eamon Ellwood, Karen Bissell, Chen-Yuan Chiang, Asma El Sony, Philippa Ellwood, Guy B. Marks, Kevin Mortimer, A. Elena Martínez-Torres, Eva Morales, Virginia Perez-Fernandez, Steven Robertson, Hywel C. Williams, David P. Strachan, Neil Pearce, the Global Asthma Network Phase I Study Group, 
Open access

From trained immunity in allergy to trained immunity-based allergen vaccines

Leticia Martín-Cruz, Carmen Sevilla-Ortega, Alba Angelina, Jorge Domínguez-Andrés, Mihai G. Netea, José Luis Subiza, Oscar Palomares, 

The evolving landscape of biologic therapies for atopic dermatitis: Present and future perspective

Eden David, Benjamin Ungar, Yael Renert-Yuval, Paola Facheris, Ester del Duca, Emma Guttman-Yassky, 

Population prevalence of allergic bronchopulmonary aspergillosis in asthma: An epidemiological study of 43,261 participants from North India

Kathirvel Soundappan, Valliappan Muthu, Sahajal Dhooria, Inderpaul Singh Sehgal, Kuruswamy Thurai Prasad, Shivaprakash Mandya Rudramurthy, Arunaloke Chakrabarti, Ashutosh N. Aggarwal, Ritesh Agarwal, 

The impact of prenatal dog keeping on infant gut microbiota development

Ariane R. Panzer, Alexandra R. Sitarik, Doug Fadrosh, Suzanne L. Havstad, Kyra Jones, Brent Davidson, Salvatore Finazzo, Ganesa R. Wegienka, Kimberley Woodcroft, Nicholas W. Lukacs, Albert M. Levin, Dennis R. Ownby, Christine C. Johnson, Susan V. Lynch, Edward M. Zoratti, 
Open access

Switching from dupilumab to tralokinumab in atopic dermatitis patients with ocular surface disease: Preliminary case series

Roselie Achten, Coco Dekkers, Daphne Bakker, Chantal van Luijk, Marlies de Graaf, Femke van Wijk, Joke de Boer, Marjolein de Bruin-Weller, Judith Thijs, 

Oral immunotherapy using boiled peanuts for treating peanut allergy: An open‐label, single‐arm trial

Luke E. Grzeskowiak PhD, Billy Tao PhD, Kamelya Aliakbari, Nusha Chegeni, Scott Morris, Tim Chataway, 
Open access

Epigenome alterations in food allergy: A systematic review of candidate gene and epigenome-wide association studies

Ramia Safar, Abderrahim Oussalah, Lina Mayorga, Stefan Vieths, Domingo Barber, Maria Jose Torres, Jean-Louis Guéant, 
Open access

Safety and effectiveness of a milk ladder for managing children with IgE-mediated milk allergy

Tessa Ah Heng, Caoimhe Cronin, Laura Flores, Francois Meyer, Meg O'Sullivan, Anne Marie McGinley, Sarah Hanley, Anne McKiernan, Yvonne D'Art, Jonathan O' B Hourihane, Roberto Velasco, Juan Trujillo, 

House dust mite components sensitization profile in China, a multi‐centre study

Hui Gan, Wenting Luo, Zhifeng Huang, Teng Zhang, Xiangqing Hou, Yanwen Chen, Zheng Zhu, Baoqing Sun, 
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The most read articles published in the Last 2 Years

Open access

Allergic diseases as risk factors for Long-COVID symptoms: Systematic review of prospective cohort studies

Doreen Wolff, Karl Philipp Drewitz, Angela Ulrich, Doreen Siegels, Stefanie Deckert, Antonia Anabella Sprenger, Paula Ricarda Kuper, Jochen Schmitt, Daniel Munblit, Christian Apfelbacher, 
Open access

BabyBathe study protocol: A randomised controlled feasibility trial to change baby bathing practice during the first months of life

Michael R. Perkin, Michael Ussher, Lucy P. Goldsmith, Carsten Flohr, Amanda Roberts, Victoria Cornelius, Charlotte Wahlich, Kathryn Willis, Robert J. Boyle, 
Open access

Trends in eczema prevalence in children and adolescents: A Global Asthma Network Phase I Study

Sinéad Máire Langan, Amy R. Mulick, Charlotte E. Rutter, Richard J. Silverwood, Innes Asher, Luis García-Marcos, Eamon Ellwood, Karen Bissell, Chen-Yuan Chiang, Asma El Sony, Philippa Ellwood, Guy B. Marks, Kevin Mortimer, A. Elena Martínez-Torres, Eva Morales, Virginia Perez-Fernandez, Steven Robertson, Hywel C. Williams, David P. Strachan, Neil Pearce, the Global Asthma Network Phase I Study Group, 
Open access

Switching from dupilumab to tralokinumab in atopic dermatitis patients with ocular surface disease: Preliminary case series

Roselie Achten, Coco Dekkers, Daphne Bakker, Chantal van Luijk, Marlies de Graaf, Femke van Wijk, Joke de Boer, Marjolein de Bruin-Weller, Judith Thijs, 
Open access

Muscle and joint pain during dupilumab treatment for atopic dermatitis: Lack of association with antinuclear antibodies

Celeste M. Boesjes, Madelon van Emst, Daphne S. Bakker, Lotte S. Spekhorst, Femke van Wijk, Marlies de Graaf, Marjolein S. de Bruin-Weller, 
Open access

Anaphylaxis mortality in the perioperative setting: Epidemiology, elicitors, risk factors and knowledge gaps

Guillaume Pouessel, Charles Tacquard, Luciana Kase Tanno, Paul Michel Mertes, Guillaume Lezmi, 
Open access

Management of Refractory Anaphylaxis: An Overview of Current Guidelines

Guillaume Pouessel, Timothy E. Dribin, Charles Tacquard, Luciana Kase Tanno, Victoria Cardona, Margitta Worm, Antoine Deschildre, Antonella Muraro, Lene H. Garvey, Paul J. Turner, 
Open access

Timing of complementary feeding for early childhood allergy prevention: An overview of systematic reviews

Paula Kuper, Claudia Hasenpusch, Simone Proebstl, Uwe Matterne, Catherine J. Hornung, Esther Grätsch, Mengtong Li, Antonia A. Sprenger, Dawid Pieper, Jennifer J. Koplin, Michael R. Perkin, Jon Genuneit, Christian Apfelbacher, 
Open access

Effectiveness of FeNO-guided treatment in adult asthma patients: A systematic review and meta-analysis

Daniël A. Korevaar, Johanna A. Damen, Pauline Heus, Maaike J. Moen, René Spijker, Ilonka H. van Veen, Els J. Weersink, Geert-Jan van Kemenade, Peter Th. W. van Hal, Lotty Hooft, 
Open access

From trained immunity in allergy to trained immunity-based allergen vaccines

Leticia Martín-Cruz, Carmen Sevilla-Ortega, Alba Angelina, Jorge Domínguez-Andrés, Mihai G. Netea, José Luis Subiza, Oscar Palomares, 
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