Clinical & Experimental Allergy is the official Journal of the British Society for Allergy & Clinical Immunology, publishing clinical and experimental observations in disease in all fields of medicine in which allergic hypersensitivity plays a part. Clinical & Experimental Allergy strikes an excellent balance between clinical and scientific articles and carries regular reviews and editorials written by leading authorities in their field.

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RESEARCH LETTER

Cluster Analysis Identifies Patients With Severe Eosinophilic Asthma Who Achieve Super‐Response and Remission With Mepolizumab

  •  10 October 2024

Graphical Abstract

Cluster Analysis Identifies Patients With Severe Eosinophilic Asthma Who Achieve Super-Response and Remission With Mepolizumab Issue ,

This study identifies two distinct subgroups of patients with severe eosinophilic asthma who respond differently to mepolizumab. Cluster analysis reveals that patients with a family history of asthma, positive skin prick tests and higher baseline lung function have better treatment outcomes, highlighting the value of personalised treatment strategies.

REVIEW ARTICLE
Open access

Adrenaline Auto‐Injectors for Preventing Fatal Anaphylaxis

  •  9 October 2024

Graphical Abstract

Adrenaline Auto-Injectors for Preventing Fatal Anaphylaxis Issue ,

During 35 years of increasing Adrenaline Autoinjector prescribing, there has been no obvious reduction in numbers of fatal anaphylaxis cases. Animal and human studies suggest intravenous adrenaline infusion, with appropriate fluid resuscitation, prevents fatal anaphylaxis. Current Adrenaline Autoinjectors may have little impact on rates of fatal anaphylaxis due to a lack of sustained and sufficient plasma adrenaline concentration.

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