Articles

ORIGINAL ARTICLE
Open access

Isolation of planarian viable cells using fluorescence‐activated cell sorting for advancing single‐cell transcriptome analysis

  •  18 September 2023

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We developed a method to isolate planarian viable cells for single-cell transcriptome analysis. The sorted cells by our method demonstrated high cell viability and high quality in single-cell RNA-seq library construction.

ORIGINAL ARTICLE

Pkd2, mutations linking to autosomal dominant polycystic kidney disease, localizes to the endoplasmic reticulum and regulates calcium signaling in fission yeast

  •  18 September 2023

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A series of truncation analyses of fission yeast Pkd2 revealed that Pkd2 localizes to the ER via transmembrane domains and regulates the cytoplasmic calcium signaling. Human Pkd2 localized to the ER and has some effect on activation of cytoplasmic calcium signaling in fission yeast; however, human PKD2 could not rescue the loss of pkd2 in fission yeast.

ORIGINAL ARTICLE
Open access

Yeast Tor complex 1 phosphorylates eIF4E-binding protein, Caf20

  •  12 September 2023

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Yeast eIF4E-binding protein Caf20 is phosphorylated by Tor complex 1 (TORC1). Caf20 may regulate translation initiation via TORC1.

REVIEW ARTICLE
Open access

Lumicrine signaling: Extracellular regulation of sperm maturation in the male reproductive tract lumen

  •  11 September 2023

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The behaviors of cells, tissues, and organs are controlled by the extracellular environment in addition to their autonomous regulatory system. Lumicrine signaling is a transluminal secreted signal transduction in the male reproductive tract lumen through which sperm functional maturation is regulated.

ORIGINAL ARTICLE

Wnt10b knockdown promotes UCP1 expression in brown adipose tissue in mice

  •  10 September 2023

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Wnt10b, a crucial member of the Wnt gene family, is involved in many physiological processes. However, the impact of Wnt10b knockdown on the function of brown adipose tissue is yet largely unknown. This study indicates that Wnt10b knockdown enhances UCP1 expression and inhibits the adipogenic differentiation of brown adipocytes, providing a novel option for therapeutic interventions in adiposity.

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