CD271, a neurotrophin receptor, contributes to cell proliferation and migration, and CD271 is a poor prognostic factor in bladder cancer.

Suppressor of cancer cell invasion mRNA expression was reduced by brain-derived neurotrophic factor in cortical neurons. Extracellular signal-regulated protein kinase/mitogen-activated protein kinase mediates the downregulation.

We discovered that IMPDH2 forms spot structures in astrocytes. Moreover, the IMPDH2 spots tended to be distributed on distal ends and branching sites of astrocyte processes. This distribution suggests yet-unidentified roles for IMPDH2, specifically at the distinctive nodes of astrocyte branches.

We introduced a novel concept and pipeline for handling the pure shape information of NGS data as probability distributions and quantifying their dissimilarities by information theory. Based on this concept, we demonstrate that the pure shape information of ATAC-seq data is correlated with chromatin openness and some gene characteristics.

The immune-related GTPase Irgb6 is markedly phosphorylated at Thr95 in response to Toxoplasma infection. Phosphorylation of Thr95 not only inactivates the GTPase activity of Irgb6 but also abrogates its binding to the Toxoplasma membrane. Structural studies elucidated the structural basis of Irgb6 inactivation by phosphorylation of Thr95 through allosteric conformational changes from the GTP pocket to the membrane binding interface.