Front Cover: A detailed analysis of PEO-PPO based block copolymers revealed the presence of diblock copolymers, which modify their HLB values. By analyzing the copolymers, the authors mapped the composition-property relationships then an artificial neural network was created providing the properties of polymer solutions for any estimated copolymer composition. More details can be found in article 2400297 by Sándor Kéki and co-workers.

Back Cover: In article 2400242, Saied Nouri Khorasani and co-workers discuss the development of a IPN hydrogel of GelMA and alginate, reinforced with nano silica. The resulted hydrogel exhibits enhanced physical, rheological and mechanical properties, and biocompatibility, making it a promising candidate for cartilage tissue engineering. The incorporation of nano silica improves the structural integrity, injectability, and functionality of the hydrogel, facilitating better integration with biological tissues.

The efficacy of the mTORC1 inhibitor temsirolimus is assessed on CD44+/CD24- CSCs from MDA-MB-231, using a 3D bone-like model with a PLA scaffold. Osteogenic differentiation of BM-MSCs and CSC invasion are induced. After applying IC50 = 5 µM for 6 hours, mTOR protein levels are evaluated, stemness, epthelial-mesenchymal transition (EMT), and drug resistance-related genes via Western Blot and Reverse transciption-quantitative polymerase chain reaction (RT-qPCR). This findings offer insights into breast-to-bone metastasis.

The self-healing property of ATSP vitrimer is demonstrated via micro-scratch repair. This is enabled by interchain transesterification reactions, a type of covalent bond exchange inherent to ester-crosslinked polymers and facilitated by high branching of chains. This healing performance is particularly significant for vitrimer-based composites, as it allows microcracks to be repaired before they merge and lead to catastrophic failure.

This study explores how different vessel orifice heights affect fiber production and morphology in pressurized gyration. Testing three orifice heights, it finds that smaller heights yield higher production rates under the effect of the pressure. These insights provide valuable optimization strategies for enhancing fiber manufacturing efficiency and scalability in industrial applications.