Clinical and Experimental Pharmacology and Physiology is a broad scope pharmacology journal aiming to advance the translation of basic research to clinical practice. The journal covers clinical and experimental pharmacology and physiology, blood pressure, cardiovascular disease, heart failure, pharmacokinetics, toxicology, and more.

 

Articles

Tanshinone IIA ameliorates the development of dermal fibrosis in systemic sclerosis

Ying Jiang, Feifei Hu, Ming Li, Qiao Li, 

Improved cardioprotective effect of 3-nitro-N-methyl salicylamide solution after a prolonged preservation time of rat heart

Shuo Wang, Wenjun Liu, Shan Liu, Jiacong Li, Yi Geng, Yungang Zhao, 

Agomelatine alleviates steroid-induced osteoporosis by targeting SIRT1/RANKL/FOXO1/OPG signalling in rats

Samaa M. El-Mahroky, Mahitab M. Nageeb, Dalia A. Hemead, Enas G. Abd Allah, 
Open access

IL-4/STAT6 axis observed to reverse proliferative defect in SCA3 patient-derived neural progenitor cells

Francis M. Chen, Huixian Li, Dittman Lai-Shun Chung, Angel T. L. Mak, Fung Ping Leung, Ho Yin Edwin Chan, Wing Tak Wong, 

Graphical Abstract

Description unavailable

Pharmacogenomics and adverse effects of anti‐infective drugs in children

Xin Huang, Biwen Hu, Ling Ye, Tong Li, Li He, Wei Tan, Guoping Yang, Jun-Ping Liu, Chengxian Guo, 

Graphical Abstract

Description unavailable

Three possible scenarios for comparing the frequency of an ADR-associated gene with the incidence of ADR in a region.

Application of 3D computed tomography in emphysematous parenchyma patients scheduled for bronchoscopic lung volume reduction

Ping Wei, Ru-Jia Tao, Hai-wen Lu, Jin-Fu Xu, Yi-han Liu, Hai Wang, Ling-Ling Li, Ye Gu, Wei-Jun Cao, 

Growth hormone‐releasing hormone beyond cancer

Nektarios Barabutis, Saikat Fakir, 
No abstract is available for this article.

Pharmacodynamic study of chitosan in combination with salvianolic acid B in the treatment of CC14-induced liver fibrosis in mice

Zhongwei Yao, Minshu Du, Yalu Wang, He Zhu, Luan Shu, Xia You, Jing Wang, 

Hsa_circ_0001204 modulates inflammatory response of macrophages infected by Mycobacterium tuberculosis via TLR4/NF-κB signalling pathway

Xiaoqing Ma, Fang Wang, Libo Zhen, Qingshan Cai, 

Graphical Abstract

Description unavailable

Research trends in ferroptosis since the origin of the concept: A bibliometric analysis

Huimin Deng, Juan Wei, Keting Min, Hao Yang, Sheng Wang, Zhuoran Xiao, Meiyun Liu, Li Zheng, Huanping Zhou, Yuanli Chen, Wanli Zhu, Quanfu Li, Xin Lv, 
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CORRECTION
free access

Correction to “Ginsenoside 20(S)-Rg3 upregulates HIF-1α-targeting miR-519a-5p to inhibit the Warburg effect in ovarian cancer cells”

  •  1005-1005
  •  2 November 2023
ORIGINAL ARTICLE

Circ_0026579 knockdown ameliorates lipopolysaccharide-induced human lung fibroblast cell injury by regulating CXCR1 via miR-370-3p

Yuanhong Zhuang, Yuyun Yang, Lihong Peng, 
  •  992-1004
  •  2 October 2023
ORIGINAL ARTICLE

Monocarboxylate transporter 4 protects against myocardial ischemia/reperfusion injury by inducing oxidative phosphorylation/glycolysis interconversion and inhibiting oxidative stress

Qiao Pan, Xiaobo Xie, Qingxia Yuan, 
  •  954-963
  •  28 September 2023
ORIGINAL ARTICLE
Open access

RAD140 (Testolone) negatively impacts skeletal muscle adaptation, frailty status and mortality risk in female mice

Austin M. Brown, Muni Swamy Ganjayi, Cory W. Baumann, 
  •  973-983
  •  27 September 2023
ORIGINAL ARTICLE

Anti-prolactin treatment alleviates lupus conditions by regulating the JAK2–STAT3 pathway

Ying Jiang, Huyan Chen, Jinran Lin, Jiewen Pan, Yanyun Shen, Qiao Li, 
  •  936-943
  •  20 September 2023
ORIGINAL ARTICLE

Impact of noscapine on halting the progression of pentylenetetrazole induced kindling epilepsy in mice

Rishav Gupta, Divya Soni, Shubham Upadhayay, Maanvi Dhureja, Puneet Kumar, 
  •  984-991
  •  19 September 2023
ORIGINAL ARTICLE

Telocytes protect against lung tissue fibrosis through hexokinase 2‐dependent pathway by secreting hepatocyte growth factor

Shaoyuan Zhang, Linyi Sun, Borong Chen, Siyun Lin, Jianmin Gu, Lijie Tan, Miao Lin, 
  •  964-972
  •  16 September 2023
ORIGINAL ARTICLE

Circ_0002295 facilitated myocardial fibrosis progression through the miR-1287/CXCR2 axis

Guo-Bin Ma, Wen-Xu Chen, Fang-Jie Zhan, Wen-Jing Xie, Rong-Wei Chen, Hong Chen, Wei-Lin Ye, Yu Jiang, Jian-Ping Xu, 
  •  944-953
  •  9 September 2023
ORIGINAL ARTICLE

Rosiglitazone inhibits acyl‐CoA synthetase long‐chain family number 4 and improves secondary brain injury in a rat model of surgical brain injury

Jinchao Shen, Min Qian, Muyao Wu, Jiafeng Tang, Yating Gong, Jie Li, Jinfen Ji, Baoqi Dang, 
  •  927-935
  •  7 September 2023

Graphical Abstract

Description unavailable

CORRECTION
free access

Correction to geldanamycin ameliorates multiple organ dysfunction and microthrombosis in septic mice by inhibiting the formation of the neutrophil extracellular network by activating heat shock factor 1 HSF1

  •  924-924
  •  31 August 2023
More articles

Articles with the most citations published in the Last Year according to CrossRef. The citation counts listed reflect the total number of all citations to date.

Immunoregulation by resveratrol; implications for normal tissue protection and tumour suppression

Armineh Rezagholi Lalani, Fatemeh Fakhari, Shakila Radgoudarzi, Nima Rastegar-Pouyani, Kave Moloudi, Ehsan Khodamoradi, Shahram Taeb, Masoud Najafi, 

A comprehensive review on medicinal plants possessing antioxidant potential

Farah Zafar, Hafiz Muhammad Asif, Ghazala Shaheen, Aymen Owais Ghauri, Sehrish Rana Rajpoot, Muhammad Wasim Tasleem, Tahira Shamim, Faheem Hadi, Raessa Noor, Tanveer Ali, Muhammad Nauman Gulzar, Halima Nazar, 

Dantrolene and ryanodine receptors in COVID-19: The daunting task and neglected warden

Luay Alkazmi, Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Maisra M. El-Bouseary, Eman A. Ahmed, Gaber El-Saber Batiha, 

Therapeutic potential of curcumin in ARDS and COVID-19

Madathilparambil V. Suresh, Sairah Francis, Sinan Aktay, Georgia Kralovich, Krishnan Raghavendran, 

Omega‐3 polyunsaturated fatty acids in the treatment of non‐alcoholic fatty liver disease: An umbrella systematic review and meta‐analysis

Vali Musazadeh, Arash Karimi, Mahsa Malekahmadi, Sana Sedgh Ahrabi, Parvin Dehghan, 
free access

Withdrawn: ‘Downregulation of circPPFIA1 elevates radiosensitivity via miR-1299–mediated TXNRD1 inhibition in oesophageal squamous cell carcinoma’, Weihui Yu, Ke Ning, Jincheng Xiao, Qiwen Bai and Chenyang Guo. (https://onlinelibrary.wiley.com/doi/10.1111/1440-1681.13751).

Weihui Yu, Ke Ning, Qiwen Bai, Chenyang Guo, 

Atractylenolide III suppresses senescence-associated secretome via inhibiting cGAS/NF-κB pathway in hepatic stellate cells

Hongyan Wu, Lixia Wu, Linxia Xiao, Yaqin Gu, Hongxia Liu, Lihu Zhang, Mingguang Zhang, Liang Qi, 

ALKBH5 inhibits the SIRT3/ACC1 axis to regulate fatty acid metabolism via an m6A-IGF2BP1-dependent manner in cervical squamous cell carcinoma

Lan Zhen, Wuyuan Pan, 

Suppressive effects of linzagolix, a novel non‐peptide antagonist of gonadotropin‐releasing hormone receptors, in experimental endometriosis model rats

Motohiro Tezuka, Kumi Tsuchioka, Kaoru Kobayashi, Yu Kuramochi, Sumiyoshi Kiguchi, 
More articles

The most read articles published in the Last Year

Open access

Protective effect of melatonin and ascorbic acid combination on sepsis‐induced lung injury: An Experimental study

Hilal Üstündağ, Özlem Demir, Betül Çiçek, Mehmet Tahir Huyut, Neslihan Yüce, Taha Tavacı, 
Open access

Moxibustion ameliorates cerebral ischemia–reperfusion injury by regulating ferroptosis in rats

JingRuo Zhang, Wa Cai, Xifang Wei, Yanbo Shi, Kun Zhang, Chen Hu, Jie Wan, Kaitao Luo, Weidong Shen, 
Open access

Bufalin reduces myocardial infarction-induced myocardial fibrosis and improves cardiac function by inhibiting the NLRP3/IL-1β signalling pathway

Xiang Wei, Yang Lv, Chenxi Yang, Rifeng Gao, Su Zou, Yingjia Xu, 
Open access

RAD140 (Testolone) negatively impacts skeletal muscle adaptation, frailty status and mortality risk in female mice

Austin M. Brown, Muni Swamy Ganjayi, Cory W. Baumann, 

A comprehensive review on medicinal plants possessing antioxidant potential

Farah Zafar, Hafiz Muhammad Asif, Ghazala Shaheen, Aymen Owais Ghauri, Sehrish Rana Rajpoot, Muhammad Wasim Tasleem, Tahira Shamim, Faheem Hadi, Raessa Noor, Tanveer Ali, Muhammad Nauman Gulzar, Halima Nazar, 
Open access

Intraoperative hemodynamics and risk of cardiac surgery‐associated acute kidney injury: An observation study and a feasibility clinical trial

Khin M. Noe, Andrea Don, Andrew D. Cochrane, Michael Z. L. Zhu, Jennifer P. Ngo, Julian A. Smith, Amanda G. Thrift, Johnny Vogiatjis, Andrew Martin, Rinaldo Bellomo, James McMillan, Roger G. Evans, 
Open access

Bach1 modulates AKT3 transcription to participate in hyperglycaemia-mediated EndMT in vascular endothelial cells

Zhipeng Meng, Wenchao Shen, Lang Yu, Fei Tong, Huanzhong He, Yonghe Hu, Weifei Wu, Jing Liu, 
Open access

Valproic acid reduces muscle susceptibility to contraction‐induced functional loss but increases weakness in two murine models of Duchenne muscular dystrophy

Dylan Moutachi, Mégane Lemaitre, Clément Delacroix, Onnik Agbulut, Denis Furling, Arnaud Ferry, 

Omega‐3 polyunsaturated fatty acids in the treatment of non‐alcoholic fatty liver disease: An umbrella systematic review and meta‐analysis

Vali Musazadeh, Arash Karimi, Mahsa Malekahmadi, Sana Sedgh Ahrabi, Parvin Dehghan, 
Open access

Role of the chloride channel blocker in the formation of filtering tract scars after glaucoma surgery in rats

Yujiao Jin, Weiyi Jin, Qiushuang Sun, Nan Li, Meiling Jiang, Yinfeng Liu, Lixia Sun, 
More articles

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Clinical and Experimental Pharmacology and Physiology now accepts free format submission to further simplify and streamline your submission process. Get to more about this program here.

Emerging Editor Program

Onwards and upwards, to recognize the outstanding contribution of up-and-coming researchers in pharmacology and physiology, we are pleased to announce the “Emerging Editors Program”. This program aims to provide an active, creative, and innovative platform for young scholars to communicate scientific ideas, improve academic impact and develop their career. Clinical and Experimental Pharmacology and Physiology sincerely invites global emerging investigators who have insight, professional foundation, strong interest, and enthusiasm in pharmacology and physiology to join the Editorial Board. Get to know more information here.