The vascular spread of pleomorphic carcinoma, mimicking pulmonary artery intimal sarcoma, represents an extremely rare mode of tumor invasion, which could be termed “arterial carcinomatosis”. Red, adenocarcinoma; Blue, spindle tumor cell spreading along the arteries; Yellow, bronchial trees.

Meflin is a new marker of mesenchymal stromal cells including perineurial cells in BAT. Oxidative stress in perineurial cells could induce sympathetic denervation and subsequent functional decline of BAT. The BAT impairment was accompanied by upregulation of a neurorepulsive factor semaphorin 3A in perineurial cells.

We visualized F. nucleatum using FISH and identified different distribution patterns of F. nucleatum, highlighting the spot density of its presence in tumor tissues. F. nucleatum was identified more frequently in esophageal cancer tissues than in the normal epithelium. As tumor progression advanced, the area occupied by F. nucleatum gradually became larger. F. nucleatum positivity was observed around the deep edge of the tumor nest or identified diffusely in the tumor nest.

Significance of REV7 in gastric adenocarcinoma (GAD) was investigated in 167 resected GAD using immunohistochemistry. Positive expression of REV7 in tumors was significantly associated with tumor undifferentiation, lymphatic invasion, and poor prognosis. REV7-depleted GAD cell lines showed enhanced sensitivity to cisplatin. Additionally, the expression levels of REV7 in the residual tumors after chemotherapy were higher than those without chemotherapy, suggesting that REV7-positive tumors are chemoresistant. These results indicate that REV7 is a predictive biomarker for prognosis and chemosensitivity in GAD.