An Exciting Partnership!

Cellular Microbiology is part of a partnership between Wiley and Hindawi and is now fully open access. Cellular Microbiology will remain a Wiley title but will be published and hosted by Hindawi and will benefit from Hindawi’s experience and expertise in publishing open access titles. Cellular Microbiology will continue to undergo a rigorous peer review process ensuring that quality remains high. Manuscripts published after January 1, 2022 will be published as open access articles, making them immediately free to read, download and share. Authors or their funder will be required to pay an Article Publication Charge upon acceptance. For further information, click here.

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Articles

RESEARCH ARTICLE

Vam6/Vps39/TRAP1-domain proteins influence vacuolar morphology, iron acquisition and virulence in Cryptococcus neoformans

  •  20 November 2021

Graphical Abstract

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The pathogenic fungus Cryptococcus neoformans must overcome iron limitation to cause disease in mammalian hosts. Two Vam6/Vps39/TRAP1 domain-containing proteins, Vps3 and Vam6, are required for robust growth on haem as well as proper regulation of iron homeostasis. Two independent deletion mutants for each gene, or double mutants lacking both genes, are unable to cause disease in a mouse inhalation model of cryptococcosis.

RESEARCH ARTICLE
Open access

Hepatitis B virus envelope proteins can serve as therapeutic targets embedded in the host cell plasma membrane

  •  3 November 2021

Graphical Abstract

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Surface immunoprecipitation of HBS confirmed that membrane-associated HBs remains correctly folded in HBV-replicating cells in cell culture. MoMab coated onto superparamagnetic iron oxide nanoparticles allowed to detect membrane-associated HBs after HBV infection by electron microscopy in distinct stretched of the hepatocyte plasma membrane. Last but not least, we demonstrate that HBs located on the cell surface allow therapeutic targeting of HBV-positive cells by T-cells either engrafted with a chimeric antigen receptor or redirected by bispecific, T-cell engager antibodies.

RESEARCH ARTICLE

Chlamydia and HPV induce centrosome amplification in the host cell through additive mechanisms

  •  30 October 2021

Graphical Abstract

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HPV and Chlamydia have additive effects on the prevalence of centrosome amplification when present in the same host cell. While HPV primarily causes centriole overduplication through expression of the oncoprotein E7, Chlamydia causes cytokinesis defects, which then lead to centrosome amplification and multinucleation in the host cell.

EDITOR'S CHOICE

Entry of the Varicellovirus Canid herpesvirus 1 into Madin–Darby canine kidney epithelial cells is pH-independent and occurs via a macropinocytosis-like mechanism but without increase in fluid uptake

  •  25 October 2021

Graphical Abstract

Description unavailable

The entry pathway of Canid herpesvirus 1 into MDCK cells was shown to be via a macropinocytosis-like mechanism. CHV-1 induces membrane ruffles and internalises within large uncoated endocytic vacuoles. Pharmacological inhibitors targeting the macropinocytic machinery blocked virus entry, while in contrast, inhibiting endosomal acidification had no effect on the ability of the virus to infect MDCK cells.

BREAKING REPORT
Open access

Dengue virus replication enhances labile zinc pools by modulation of ZIP8

  •  7 October 2021

Graphical Abstract

Description unavailable

Dengue virus infection was shown to induce intracellular labile zinc pools which colocalized with ER and Golgi markers. ZIP8 levels were enhanced during early stages of dengue virus replication and silencing ZIP8 blocked increase in labile zinc levels and inhibited viral replication.

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