Editor in Chief: John Kuriyan
Senior Editors: Nir Ben-Tal, Aitziber L. Cortajarena, and Lynn Kamerlin
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Protein Science, the flagship journal of The Protein Society, publishes original reports and review articles that advance fundamental knowledge, in the broadest sense, concerning protein molecules. The journal welcomes papers describing experimental and computational or theoretical studies focused on protein function, including analyses of mechanism, structure, folding, design, and evolution. Additionally, we invite papers discussing the practical applications of protein science in the areas of therapeutics, protein-based biomaterials, bionanotechnology, synthetic biology, and bioelectronics.

We are proud to announce and congratulate the winners of the 2023 Protein Science Best Paper awards: Evan T. Liechty (University of Colorado, USA) and Sophie Rizzo (Lehigh University, USA).
Featured
Articles
A new view of missense mutations in α-mannosidosis using molecular dynamics conformational ensembles
-  24 March 2025
Comparison of enriched charge variants from different anti-CD3 bispecific antibodies reveals differential susceptibility of each bispecific arm to post-translational modification
-  21 March 2025
Computational studies on the functional and structural impact of pathogenic mutations in enzymes
-  21 March 2025
Data‐driven evaluation of suitable immunogens for improved antibody selection
-  21 March 2025
Fibrinogen-binding M-related proteins facilitate the recruitment of plasminogen by Streptococcus pyogenes
-  18 March 2025
The collection consists of our top 10 recent reviews that have been published in 2017 and 2018.
While the revolution will not be crystallized, biochemistry reigns supreme
- Protein Science
-  69-81
-  10.1002/pro.3054
Determination of the ribosome structure to a resolution of 2.5 Å by single‐particle cryo‐EM
- Protein Science
-  82-92
-  10.1002/pro.3068
A cell is more than the sum of its (dilute) parts: A brief history of quinary structure
- Protein Science
-  403-413
-  10.1002/pro.3092
(S)Pinning down protein interactions by NMR
- Protein Science
-  436-451
-  10.1002/pro.3105
Modulating the wnt signaling pathway with small molecules
- Protein Science
-  650-661
-  10.1002/pro.3122
Targeting human SET1/MLL family of proteins
- Protein Science
-  662-676
-  10.1002/pro.3129
Monobodies and other synthetic binding proteins for expanding protein science
- Protein Science
-  910-924
-  10.1002/pro.3148
Global substrate specificity profiling of post‐translational modifying enzymes
- Protein Science
-  584-594
-  10.1002/pro.3352
Recent issues
- Volume 34, Issue 4April 2025
- Volume 34, Issue 3March 2025
- Volume 34, Issue 2February 2025
- Volume 34, Issue 1January 2025