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Edited By: Jörg Schulz
Impact factor:4.609
ISI Journal Citation Reports © Ranking:
2017:56/293 (Biochemistry & Molecular Biology)
ISI Journal Citation Reports © Ranking:
2017:57/261 (Neurosciences)
Online ISSN:1471-4159
© International Society for Neurochemistry
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more >free access
Issue Cover (May 2019)
- Journal of Neurochemistry
- 25 April 2019
Abstract
Front cover:Amyloid precursor protein (APP) is processed to form the amyloid‐β (Aβ) which is a key component in the initiation of Alzheimer‘s disease. Aβ is preferentially produced from the 695 isoform of APP indicating that the different isoforms are differentially processed and may have different interactomes that regulate their processing. Stable isotope labelling of amino acids in cell culture (SILAC) and quantitative proteomics identified different interactomes for the 695 and 751 isoforms of APP. These data identify new proteins that may be important in regulating Aβ production.
Image content: Immunofluorescent microscopy image of APP695‐FLAG (green) and its subcellular localisation in relation to the trans‐Golgi network marker TGN‐46 (red). APP695‐FLAG has punctate staining within the cell and its localisation overlapped with that of TGN‐46 (yellow) indicating that APP is located in the trans‐Golgi network.
Read the full article ‘Quantitative interaction proteomics reveals differences in the interactomes of amyloid precursor protein isoforms’ by R. J. Andrew, K. Fisher, K. J. Heesom, K. A. B. Kellett, N. M. Hooper (J. Neurochem. 2019, vol. 149 (3), pp. 399–412) on doi: 10.1111/jnc.14666
free accessProteomics; applications in familial Parkinson's disease
- Journal of Neurochemistry
- 25 April 2019
α‐synuclein oligomers enhance astrocyte‐induced synapse formation through TGF‐β1 signaling in a Parkinson's disease model
- Luan Pereira Diniz
- Isadora Matias
- Ana Paula Bérgamo Araujo
- Matheus N. Garcia
- Fernanda Barros Aragão
- Soniza Vieira Alves‐Leon
- Jorge Marcondes de Souza
- Débora Foguel
- Cláudia P. Figueiredo
- Carolina Braga
- Luciana Romão
- Flávia Carvalho Alcantara Gomes
- Journal of Neurochemistry
- 22 April 2019
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The following is a list of the most cited articles based on citations published in the last three years, according to CrossRef.
more >free accessOxidative stress and neurodegeneration: where are we now?
- Journal of Neurochemistry
- 1634-1658
- 19 June 2006
THE EFFECT OF AGE ON THE NON‐HAEMIN IRON IN THE HUMAN BRAIN
- Journal of Neurochemistry
- 41-51
- October 1958
Mitochondrial Complex I Deficiency in Parkinson's Disease
- Journal of Neurochemistry
- 823-827
- March 1990
THE [14C]DEOXYGLUCOSE METHOD FOR THE MEASUREMENT OF LOCAL CEREBRAL GLUCOSE UTILIZATION: THEORY, PROCEDURE, AND NORMAL VALUES IN THE CONSCIOUS AND ANESTHETIZED ALBINO RAT1
- L. Sokoloff
- M. Reivich
- C. Kennedy
- M. H. Des Rosiers
- C. S. Patlak
- K. D. Pettigrew
- O. Sakurada
- M. Shinohara
- Journal of Neurochemistry
- 897-916
- May 1977
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