Aging Cell is an open access geroscience journal publishing research addressing the biology of aging. The journal welcomes research that reports the mechanistic, molecular, and cellular aspects of the aging process, as well as the links between aging and age-related disease.

With global readership, Aging Cell is a journal of The Anatomical Society and John Wiley and Sons, Ltd.

  • Rilmenidine extends lifespan and healthspan in Caenorhabditis elegans via a nischarin I1-imidazoline receptor

    Dominic F. Bennett, Anita Goyala, Cyril Statzer, Charles W. Beckett, Alexander Tyshkovskiy, Vadim N. Gladyshev, Collin Y. Ewald, João Pedro de Magalhães

    Aging Cell, Volume 22, Issue 2, February 2023, Pages 1-15

    Accepted Dec 09, 2022. First published: 20 January 2023

    https://doi.org/10.1111/acel.13774

  • A single short reprogramming early in life initiates and propagates an epigenetically related mechanism improving fitness and promoting an increased healthy lifespan

    Quentin Alle, Enora Le Borgne, Paul Bensadoun, Camille Lemey, Nelly Béchir, Mélissa Gabanou, Fanny Estermann, Christelle Bertrand-Gaday, Laurence Pessemesse, Karine Toupet, Romain Desprat, Jérôme Vialaret, Christophe Hirtz, Danièle Noël, Christian Jorgensen, François Casas, Ollivier Milhavet, Jean-Marc Lemaitre

    Aging Cell, Volume 21, Issue 11, November 2022, Pages 1-12

    Accepted Aug 31, 2022. First published: 17 October 2022

    https://doi.org/10.1111/acel.13714

  • NEW RESEARCH STUDENTSHIPS 2023/24 - AWARDED FOR START DATE 01.10.24

    Award of Anatomical Society Studentships

    The Anatomical Society is delighted to announce the award of two new research studentships. These awards are the outcome of the Society’s annual studentship competition open to its members. Studentships will start in October 2024 and each award funds 3 years of postgraduate training and study towards a PhD. Studentships provide funding for research focused on specific projects associated with anatomical science. For details of these funded projects, please click here.

Articles

RESEARCH ARTICLE
Open access

Cellular senescence by loss of Men1 in osteoblasts is critical for age-related osteoporosis

  •  22 June 2024

Graphical Abstract

Description unavailable

Osteoblast-specific inducible Men1 knockout mimics age-related osteoporosis even in young mice. Men1 deletion in osteoblasts promotes replicative stress-induced cellular senescence presumably through mTORC1 activation and AMPK suppression, rescued by metformin treatment.

RESEARCH ARTICLE
Open access

A new gene signature for endothelial senescence identifies self-RNA sensing by retinoic acid-inducible gene I as a molecular facilitator of vascular aging

  •  21 June 2024

Graphical Abstract

Description unavailable

Establishment and validation of a new gene signature EndoSEN to identify senescent endothelial cells. An interferon-stimulated gene signature is a hallmark of senescent endothelial cells. RNA sensor RIG-I is activated in senescent endothelial cells. Human senescent endothelial cells accumulate endogenous self-RNA. Knockdown of RIG-I extended the lifespan and decreased the inflammatory phenotype (SASP) in aged endothelial cells.

RESEARCH ARTICLE
Open access

Single‐cell mitochondrial sequencing reveals low‐frequency mitochondrial mutations in naturally aging mice

  •  21 June 2024

Graphical Abstract

Description unavailable

We focused on optimizing the single-cell ATAC sequencing workflow using the DNBelab C4 platform for mitochondrial analysis. Validating the method on the HEK-293T cell line, we successfully captured mitochondrial content and simultaneous information on open chromatin status. We also applied it to aged spleen and bone marrow tissues from mice, proved its efficiency in profiling mtDNA variations in tissues.

RESEARCH ARTICLE
Open access

Lens capsule advanced glycation end products induce senescence in epithelial cells: Implications for secondary cataracts

  •  21 June 2024

Graphical Abstract

Description unavailable

Advanced glycation end products (AGEs) in the posterior capsule of the lens induce senescence of lens epithelial cells (LECs). The senescent LECs secrete senescence-associated secretory phenotype (SASP) and promote epithelial-to-mesenchymal transition of non-senescent LECs. These events could potentially contribute to fibrosis during the development of posterior capsule opacification after cataract surgery in elderly patients.

COMMENTARY
Open access

Achilles' spear: A new therapeutic target for age-related diseases

  •  21 June 2024

Graphical Abstract

Description unavailable

Following anti-miMOMP treatment, patients with age-related diseases exhibited improvements. However, when these patients were treated with anti-tumour therapy concurrently, the anti-tumour effect diminished and tumour progression ensued. The conjecture about anti-miMOMP treatment proposed in this paper may be an important research direction in this field in the future.

More articles

The following is a list of the most cited articles based on citations published in the last three years, according to CrossRef.

Open access

Oxidative stress in the aging substantia nigra and the etiology of Parkinson's disease

  •  20 August 2019

Graphical Abstract

Description unavailable

Dopamine neurons within the healthy human substantia nigra exhibit mild oxidative stress during aging, resulting from their unique biochemical properties and a number of age-dependent biochemical changes specific to this neuronal population (grey). An exacerbation of these pathways, combined with additional environmental toxins and genetic mutations, worsens redox balance within nigral dopamine neurons in Parkinson's disease, causing excessive oxidative stress and dopamine neuron death (red).

Open access

Measuring biological aging in humans: A quest

  •  12 December 2019

Graphical Abstract

Description unavailable

Finding a reference metric for the rate of biological aging is key to understanding the molecular nature of the aging process. Defining and validating this metric in humans opens the door to a new kind of medicine that will overcome the limitation of current disease definitions. We will then be able to approach health in a global perspective and bring life course preventative measures to the center of attention.

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