Translational Geroscience poses that slowing down the underlying mechanisms of aging will result in prevention of most diseases and disabilities that affect older persons. To facilitate this transformation will require a closer collaboration and wider discussion between gerontologists who study aging in research laboratories (geroscience) and geriatricians who maintain life course records and care for older patients with complex multimorbidity and disability (geriatric care). Figure generated using Office suite and Biorender.

Individuals with a high polygenic risk for schizophrenia seem to display accelerated epigenetic aging at higher (vs. lower) inner drive for social relationships. A rather opposite pattern was found among those with a low polygenic risk for schizophrenia. Thus, frequent social interactions may relate to accelerated epigenetic aging in individuals at risk for psychosis.

Although systemic mTOR inhibition improves age-related physiological dysfunction, the cell types that mediate the beneficial effects remain elusive. Here, we demonstrate that endothelial cell-specific reduction of mTOR ameliorates arterial and metabolic function in old age. These improvements are concomitant with reduced senescence burden, inflammation, and oxidative stress in arteries, lung, adipose tissue, and liver. These results support the exploration of therapeutic strategies targeting endothelial mTOR signaling.