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BioEssays is renowned for its collection of contemporary and forward-looking biology reviews. Our review-and-discussion journal publishes everything molecular, genetic and cellular biology.
We serve the biological community as a discussion forum for new ideas in these areas and encourage transdisciplinary and integrative biological approaches. BioEssays does not consider original research but is open to analyses based on formally published data.
On the Cover
The longevity bottleneck hypothesis: Could dinosaurs have shaped ageing in present‐day mammals?
-  28 November 2023
The longevity bottleneck hypothesis states that early mammals spending over 100 million years as small, short-lived animals led to gene loss or inactivation of traits associated with longevity and left a legacy that is observed in the marked ageing phenotype of modern mammals, in particular long-lived species such as humans.
Lung patterning: Is a distal‐to‐proximal gradient of cell allocation and fate decision a general paradigm?
-  27 November 2023
SOX9+ epithelial progenitors at distal tips of lung branches undergo cell allocation and differentiation sequentially along the distal-to-proximal axis. The proximal progeny becomes the conducting airways while the distal descendants produce alveolar cells. This model represents our current understanding of how cell number and fate decisions contribute to lung patterning.
Environmental factor reversibly determines cellular identity through opposing Integrators that unify epigenetic and transcriptional pathways
-  27 November 2023
Organisms adapt to environmental demands, ensuring their survival and well-being by modifying cellular identities, shaped by chromatin configurations. Here, we propose that environmental signals are sensed by “Integrators”, orchestrating the epigenetic and transcriptional processes governing cellular identity. Adverse environmental factors such as pollution disrupt epigenetic control contributing to disease development.
Origin and development of primary animal epithelia
-  27 November 2023
Epithelia are the first organized structures to appear during animal development and evolution. Although key characteristics are shared among diverse epithelia, the mechanism they form is highly divergent. The challenge for dividing cells in the early embryo to form the primary epithelium has been resolved in unique ways across Metazoa.
Loss of DNA methylation disrupts syncytiotrophoblast development: Proposed consequences of aberrant germline gene activation
-  22 November 2023
DNA methyltransferase 3B (Dnmt3b) knockout conceptuses show embryonic lethality due to impaired placental formation. These placental cells exhibit aberrant DNA methylation and de-repression of germline genes. We propose that germline gene expression disrupts normal placental development through altered transcript regulation, disrupted cell division, and spurious piRNA silencing of endogenous retroviruses.
The following is a list of the most cited articles based on citations published in the last three years, according to CrossRef.
The structure and synthesis of the fungal cell wall
-  22 August 2006
Reactive oxygen species as signals that modulate plant stress responses and programmed cell death
-  13 October 2006
Spatially Resolved Transcriptomes—Next Generation Tools for Tissue Exploration
-  4 May 2020
The PARP superfamily
-  19 July 2004
Phototoxicity in live fluorescence microscopy, and how to avoid it
-  27 July 2017
Phototoxicity during live fluorescence microscopy is a frequent side effect of excess illumination that can influence data quality. Samples can be affected by phototoxicity even before it becomes obvious from their morphology. In this review, we explore how to mitigate and control for phototoxicity to collect reliable quantitative imaging data.