N6-methyladenosine (m6A) modification in eukaryotic RNAs has drawn much attention in breast cancer research recently. It impacts breast cancer's onset, progression, and prognosis via regulating RNA-related processes. m6A regulatory factors play key roles. Also, its interactions with non-coding RNAs and in the tumor microenvironment are of interest. Despite some known dual roles, its mechanisms need further study. This article summarizes the research to aid future research and clinical applications.

This study investigates the role of FOXA3 in esophageal squamous cell carcinoma (ESCC). FOXA3 expression was significantly reduced in ESCC tissues and correlated with poor prognosis. Overexpression of FOXA3 inhibited ESCC cell proliferation, migration, and invasion in vitro and tumor growth in vivo. These findings suggest that FOXA3 acts as a tumor suppressor in ESCC and may serve as a potential diagnostic and therapeutic target.

This review focuses on the relationship between non-coding RNAs and the sirtuin (SIRT1-7) family and summarizes the impact of their interactions on mitochondrial metabolism, oxidative stress, mitochondrial apoptotic pathways, mitochondrial biogenesis, mitochondrial dynamics, and other mitochondria-related pathophysiological processes.

This study investigates the mechanism of Icariin (ICA) in postmenopausal osteoporosis (PMO) rats. ICA increased bone mass and reduced bone marrow fat in ovariectomized (OVX) rats. It promoted osteogenic differentiation and inhibited adipogenic differentiation of bone marrow-derived stem cells (BMSCs). Overexpression of SOST countered ICA’s effects, whereas Wnt pathway activation with TWS119 restored them. ICA reduced SOST expression by diminishing ERα binding to its promoter, with methylation of SOST inhibiting this interaction. Overall, ICA enhances SOST methylation, promoting osteogenic differentiation in BMSCs.

This study used Mendelian randomization to explore the causal relationship between type 1 diabetes (T1D) and idiopathic pulmonary fibrosis (IPF). Analysis of genome-wide association study data revealed that T1D increases the risk of IPF (OR: 1.132, p = 0.005), with results remaining consistent after adjusting for aging. The findings suggest a potential causal link between T1D and IPF, meriting further investigation.

Pericarpium Trichosanthis (PT) alleviates cardiac fibrosis and improves cardiac function in CHF rats. Moreover, PT could inhibit TGF-β1/Smad3 signaling by promoting the expression of miR-29b.