Copper ions induced prostate cell death. In prostate cancer cells (DU145, PC-3, C4-2B and LNCap), excess copper ions caused abnormal aggregation of thioredoxin in the tricarboxylic acid cycle pathway by directly binding to thioredoxin and interfering with iron–sulfur cluster proteins in the respiratory chain complex, causing a proteotoxic stress response that ultimately leads to cell death.

The research identified several genes associated with osteoporosis, such as CASP9, CASP8, CASP3, BAX and TP53. Pathway analysis revealed the involvement of caspase activation through the extrinsic apoptotic signaling pathway. Protein networks and central gene interactions were explored, and the study emphasized the significance of understanding the pathways of osteoporosis apoptosis for predicting susceptibility to the disease.

In the present study, we conducted a comprehensive analysis of differential mRNA and microRNA (miRNA) expression based on silicosis patients and normal people. Many differentially expressed mRNAs and miRNAs between their lung tissues were identified. There was no significant difference for most mRNA or miRNA expression between early stage and advanced stage silicosis lung tissues. In addition, PTEN and GNAI3 expression between lung tissues and blood samples suggested the opposite. PTEN was identified as potential biomarker for silicosis as a result of low methylation in the blood.

The neutrophil extracellular traps (NETs)-related model provides a promising prospect as a prognostic indicator. The nomogram model suggested a favorable classification performance. The immune status of the two risk groups showed a marked difference. Single cell RNA dataset and PCR were performed as validation.

Proline is essential for tumor cell metabolism, and pyrroline-5-carboxylate reductase 1 (PYCR1) is a pivotal enzyme for converting P5C to proline. An antisense lncRNA, RP11-498C9.13 increases PYCR1 in bladder cancer by stabilizing the PYCR1 mRNA. PYCR1 promotes the proliferation and invasiveness of bladder cancer cells and enhances reactive species induced-induced mitophagy.

Workflow of this study. First, the expression of RNA modification factors and characteristics of immune infiltration in RA and normal synovial tissues were compared. Then, the prediction model and drug/TF–RNA modification interaction networks were constructed, followed by molecular subtype analysis. Finally, the biomarker was screened.

The proposed working model of B4GALNT1 functions as a tumor carcinogenesis through regulating epithelial-mesenchymal transition (EMT) in hepatocellular carcinoma (HCC) based on pan-cancer analysis. B4GALNT1 promoted the expression of apoptosis-related or EMT-related proteins and then decreased the expression of Bcl-2 and Bcl-xl in HCC cells, suggesting that B4GALNT1 may serve as a promising predictive biomarker and potential therapeutic target for HCC.

The results demonstrate clear dynamic microRNA (miRNA) expression during palate development. The mesenchymal cell proliferation and apoptosis related miRNAs and genes are important during development of palate in fetal mice, including mmu-miR-6715-5p-Fgf4, mmu-miR-149-3p-Vegfa, mmu-miR-669m-5p/mmu-miR-466m-5p-Bmp7, mmu-miR-504-3p-Hnf1b, mmu-miR-6912-5p-Pax2, etc.

The present study included 726 type 2 diabetes (T2D) cases, divided into 222 with nephropathy and 504 cases without nephropathy, and 310 controls. Demographic data and blood samples were taken from participants. DNA was extracted and genotyped for MMP-2, −1306C/T, −790T/G, −1575G/T and −735C/T by a real-time PCR. The −790G allele and GCGC, GTAC haplotypes are associated with a risk of diabetic nephropathy (DN).