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Angewandte Chemie is a journal of the German Chemical Society (GDCh). It is one of the prime chemistry journals in the world. It is the only journal in the field delivering a stimulating mixture of Review-type articles, Highlights, Communications, and Research Articles. New articles appear online almost every day.

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Cover Picture: Biomimetic Amino Acid Functionalized Phenazine Flow Batteries with Long Lifetime at Near-Neutral pH (Angew. Chem. Int. Ed. 10/2021)
Aqueous organic redox flow batteries (AORFB) are a promising electrochemical technology for large-scale energy storage. In their Research Article on page 5289, Pan Wang, Yunlong Ji et al. report a biomimetic, ultra-stable AORFB utilizing an amino acid functionalized phenazine (AFP), thus demonstrating the importance of molecular engineering of redox-active organics for robust redox-flow batteries.
Inside Cover: Interaction with Ribosomal Proteins Accompanies Stress Induction of the Anticancer Metallodrug BOLD-100/KP1339 in the Endoplasmic Reticulum (Angew. Chem. Int. Ed. 10/2021)
A multi-omics approach including proteomics, transcriptomics, and imaging was applied to comprehensively investigate the mode of action of the anticancer ruthenium(III) drug candidate BOLD-100. In their Communication on page 5063, Samuel M. Meier-Menches, Christopher Gerner, and co-workers found the ribosomal proteins RPL10, RPL24, and the transcription factor GTF2I as probable protein targets. They are functionally connected to endoplasmic reticulum stress, a key drug effect of BOLD-100.
Inside Back Cover: Seven-Step Synthesis of All-Nitrogenated Sugar Derivatives Using Sequential Overman Rearrangements (Angew. Chem. Int. Ed. 10/2021)
All-nitrogenated sugars (ANSs), in which all hydroxy groups in a carbohydrate are replaced with amino groups, are anticipated to be privileged structures with useful biological activities. In their Communication on page 5193, Takaaki Sato, Noritaka Chida, and co-workers report the synthesis, transformation, and biological tests of ANS derivatives. The key to success was a seven-step synthesis of ANSs by a sequential Overman rearrangement enabling formal simultaneous substitution of four or five hydroxy groups in monosaccharides with amino groups.
Back Cover: Potent Trivalent Inhibitors of Thrombin through Hybridization of Salivary Sulfopeptides from Hematophagous Arthropods (Angew. Chem. Int. Ed. 10/2021)
A novel class of trivalent thrombin inhibitor is reported by Pedro José Barbosa Pereira, Richard J. Payne, and co-workers in their Research Article on page 5348. These inhibitors were rationally designed by hybridizing native sulfopeptide thrombin inhibitors from three different invertebrates: variegin from a bont tick, anophelin from the Anopheles mosquito, and TTI from the tsetse fly. When fused using bidirectional peptide synthesis and peptide ligation technologies the resulting hybrid inhibitors exhibited exquisite potency both in vitro, with femtomolar inhibition constants, and in an in vivo model of thrombosis.
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February 23, 2021

Angewandte Chemie 10/2021: A Roadmap for Chemistry

anie.202181061.jpgIn this issue, S. Kaskel et al. review porphyrin-based metal–organic frameworks for biomedical applications. C. Yang et al. summarize performance-enhancing approaches for PEDOT:PSS-Si hybrid solar cells. The Minireviews deal with binary (split) light-up aptameric sensors (D. M. Kolpashchikov, A. A. Spelkov) and activity-based sensing probes for isoform-selective imaging of enzymatic activity (J. Chan et al.). In his Guest Editorial, J. Garcia-Martinez presents a roadmap for chemistry in the new decade.

In the original research section, S. R. Waldvogel et al. describe a metal-free electrochemical synthesis of sulfonamides directly from (hetero)arenes, SO2, and amines (see picture). S. Komaba et al. succeeded in the MgO-template synthesis of extremely high capacity hard carbon for Na-ion batteries. S. Ma et al. developed a MOF-based ultra-strong acetylene nano-trap for highly efficient C2H2/CO2 separation. R. M. Rodriguez Sarmiento et al. found novel β-glucocerebrosidase activators that bind to a new pocket at a dimer interface and induce dimerization. T. H. Ware et al. demonstrate 4D-printing of photoswitchable actuators.

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Editorial

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Chemistry 2030: A Roadmap for a New Decade

  •  4956-4960
  •  1 February 2021

Abstract

This new decade poses many new challenges at many different levels. The SIDE vision for Chemistry 2030 gathers the main recommendations from various organizations and initiatives and provides a roadmap for the advancement of chemistry and to respond to increasingly complex and interconnected challenges.

Press Release

Screening for Macrocyclic Peptides

Dimeric cyclic peptides are potent modulators of ubiquitin, an apoptosis regulator

Screening for Macrocyclic Peptides - Dimeric cyclic peptides are potent modulators of ubiquitin, an apoptosis regulator

Macrocyclic peptides are promising candidates for pharmaceuticals, but their screening is difficult. Scientists have now developed an easy-to-use, high-throughput screening assay for cyclic peptides with affinity to ubiquitin, a protein that helps to degrade proteins and induce cell death. The results could lead to novel drug candidates against cancer, according to the study published in the journal Angewandte Chemie.

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