Edited By: Andrew Holmes
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The Collaborative Study on the Genetics of Alcoholism: Overview
- 22 September 2023
Graphical Abstract
COGA is a family based, diverse (~25% self-identified African American, ~52% female) sample, including data on 17,878 individuals, ages 7–97 years, in 2246 families of which a proportion are densely affected for AUD. This overview provides the framework for the development of COGA as a scientific resource in the past three decades, with individual reviews providing in-depth descriptions of data on and discoveries from behavioral and clinical, brain function, genetic and functional genomics data.
Collaborative study on the genetics of alcoholism: The strength of collaboration, team science, and longitudinal data
- 19 September 2023
The collaborative study on the genetics of alcoholism: Brain function
- 17 August 2023
Graphical Abstract
In this review, we provide an overview of the neurophysiological and neuropsychological measures that have been collected within the COGA sample. We also provide illustrative examples of how these data, in combination with the rich genetic and phenotypic longitudinal data available, have advanced our understanding of the etiology and consequences of alcohol use disorder and related disorders.
The collaborative study on the genetics of alcoholism: Sample and clinical data
- 15 August 2023
Graphical Abstract
The multi-generational, family-based collaborative study on the genetics of alcoholism (COGA) has for over 30 years studied nearly 18,000 individuals from over 2200 families with a rich protocol to better understand alcohol use, problems, and disorder. Participants provide a wide range of information through psychiatric interviews, electrophysiological measures, neuropsychological evaluations, and genomic data. These data are broadly available to other researchers. Here, we provide an overview of COGA's data collection and sample characteristics, along with key research findings, in order to encourage further use of COGA data to help advance the field.
5. Collaborative Study on the Genetics of Alcoholism: Functional genomics
- 2 August 2023
Graphical Abstract
Alcohol Use Disorder is a complex genetic disorder, involving genetic, neural, and environmental factors, and their interactions. The Collaborative Study on the Genetics of Alcoholism (COGA) has been investigating these factors and identified putative alcohol use disorder risk genes through genome-wide association studies. In this review, we describe advances made by COGA in elucidating the functional changes induced by alcohol use disorder risk genes using multimodal approaches with human cell lines and brain tissue.
The following is a list of the most cited articles based on citations published in the last three years, according to CrossRef.
Model of autism: increased ratio of excitation/inhibition in key neural systems
- 255-267
- 16 October 2003
Sociability and preference for social novelty in five inbred strains: an approach to assess autistic‐like behavior in mice
- 287-302
- 29 April 2004
Microbial genes, brain & behaviour – epigenetic regulation of the gut–brain axis
- 69-86
- 28 November 2013
Graphical Abstract
Epigenetics in host–microbe interactions has received little attention. In this review we put forward novel hypotheses.
Impaired reversal learning in the Dlg2+/− rat model of genetic risk for psychiatric disorder: Important questions regarding the neuro‐behavioral mechanisms of reversal learning
- Genes, Brain and Behavior
- 4 December 2023
The polygenic and reactive nature of observed parenting
- Genes, Brain and Behavior
- 29 November 2023
Graphical Abstract
We replicated the Dunedin study on the relation between the polygenic score for educational attainment and observed sensitivity but also showed that the children's genotypic make-up has to be taken into account. Our results point to the role of evocative gene–environment correlation in the dynamic interactions between parents and children.
PAC1 receptor modulation of freezing and flight behavior in periaqueductal gray
- Genes, Brain and Behavior
- 20 November 2023
Graphical Abstract
PAC1 receptors were conditionally deleted from the ventrolateral PAG where PACAP-positive cells are primarily located, performed fear conditioning experiments were conducted. Lacking PAC1 receptors showed defensive responses inappropriate to the situation such as freezing, activity burst and darting. The findings suggested that intact PACAP-PAC1 mechanisms are essential for intact species-specific defensive reactions in ventrolateral PAG.
Association of polygenic scores for depression and neuroticism with perceived stress in daily life during a long‐lasting stress period
- Genes, Brain and Behavior
- 24 October 2023
Graphical Abstract
In the LawSTRESS project, a study with a prospective-longitudinal quasi-experimental design, German law students experiencing (stress group) or not experiencing (control group) a long-lasting stress phase were examined. We analyzed whether polygenic scores (PGS) for depression and neuroticism, respectively, were associated with perceived stress levels in daily life. For the neuroticism PGS we found a significant GxE effect; only in the stress group a higher PGS predicted stronger increases of perceived stress levels over 13 months.
Nature and nurture: Comparing mouse behavior in classic versus revised anxiety‐like and social behavioral assays in genetically or environmentally defined groups
- Genes, Brain and Behavior
- 23 October 2023
Graphical Abstract
Revised anxiety-like assays that introduce continual motivational conflict may improve upon “classic” assays like the elevated plus maze or open field test. Findings suggest that classic assays may sufficiently characterize differences across genetically defined groups, but the revised 3DR may be advantageous for investigating more nuanced behavioral differences such as those stemming from environmental factors.
The developmental impact of sex chromosome trisomies on emerging executive functions in young children: Evidence from neurocognitive tests and daily life skills
- Genes, Brain and Behavior
- 18 May 2022
Graphical Abstract
The current study shows that a sex chromosomal trisomy (SCT) in children is associated with an increased risk for problems with emerging executive functions, from as early as 3 years old, and that those problems appear more pronounced with increasing age. Furthermore, the vulnerability for difficulties with executive functions appears broader than the language domain alone, extending to other areas as well. Preschool executive functions are vital for school readiness, academic success, and psychological functioning, putting children with SCT at a developmental disadvantage compared to peers.
The genetics of human personality
- Genes, Brain and Behavior
- 20 November 2017
Graphical Abstract
Genome-wide association studies hits (log10 transformed) discovered as a function of sample size and personality trait.
Epigenetics at the crossroads between genes, environment and resilience in anxiety disorders
- Genes, Brain and Behavior
- 5 September 2017
Graphical Abstract
This review discusses the current state of knowledge regarding putative risk factors in the etiology of anxiety disorders and the role of epigenetic regulation as a non-canonical mode of genetic influence moderating the complex interplay between genetic, environmental and psychological influences. We place a particular focus on protective factors serving to buffer a risk factor constellation toward a better understanding of the mechanisms at the interface of risk or resilience to anxiety.
A genome‐wide association study identified new variants associated with mathematical abilities in Chinese children
- Genes, Brain and Behavior
- 22 February 2023
Graphical Abstract
We identified seven genome-wide significant single nucleotide polymorphisms (SNPs) with strong linkage disequilibrium among each other associated with mathematical reasoning ability (top SNP: rs34034296, p = 2.01 × 10−8, nearest gene: CUB and Sushi multiple domains 3, CSMD3). We replicated one SNP (rs133885) from 585 SNPs previously reported to be associated with general mathematical ability associated with division ability in our data (p = 1.053 × 10−5). In the gene- and gene-set enrichment analysis by MAGMA, we found three significant enrichments of associations with three mathematical ability categories for three genes (LINGO2, OAS1 and HECTD1). We also observed four significant enrichments of associations with four mathematical ability categories for three gene sets.
Reconsidering animal models used to study autism spectrum disorder: Current state and optimizing future
- Genes, Brain and Behavior
- 14 March 2022
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Published jointly with the International Behavioural and Neural Genetics Society (IBANGS)
