Molecular Nutrition & Food Research is a food science journal devoted to health, safety and all aspects of molecular nutrition, including nutritional biochemistry, nutrigenomics, and metabolomics.

With over 60 years of publishing high quality original research, the journal aims to advance the field in a sustainable manner. Our focus is on food and nutrition at the molecular level, attracting a wide readership of researchers studying bioactivity, immunology, microbiology and chemistry in this field.

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Review

Vitamin D and Atherosclerosis: Unraveling the Impact on Macrophage Function

  •  12 June 2024

Graphical Abstract

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Vitamin D exerts its anti-atherosclerotic effect by regulating macrophage function. It regulates various aspects of macrophage activity, including inhibiting monocyte and macrophage recruitment, impeding macrophage cholesterol uptake and esterification, inducing autophagy of lipid droplets within macrophages, promoting macrophage cholesterol efflux, regulating macrophage polarization, and suppressing the formation, adhesion, and migration of lipid-loaded monocytes, further contributing to its anti-atherosclerotic properties.

Research Article

Kaempferol‐Enhanced Migration and Differentiation of C2C12 Myoblasts via ITG1B/FAK/Paxillin and IGF1R/AKT/mTOR Signaling Pathways

  •  11 June 2024

Graphical Abstract

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Schematic diagram of KMP regulation of C2C12 myoblast migration and myogenic differentiation. AKT, protein kinase B; CDC42, cell division cycle 42; ECM, cell-extracellular matrix; FAK, focal adhesion kinase; IGF1R, insulin-like growth factor 1 receptor; ITGB1, integrin subunit beta 1; MHC, myosin heavy chain; mTOR, mammalian target of rapamycin; P70S6K, ribosomal protein S6 kinase beta-1/p70S6 kinase.

Research Article

Hyperglycemia Inhibits Hepatic SHBG Synthesis Through the NGBR‐AMPK‐HNF4 Pathway in Rats with Polycystic Ovary Syndrome Induced by Letrozole in Combination with a High‐Fat Diet

  •  11 June 2024

Graphical Abstract

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Hypothetical mechanism of NgBR regulating liver SHBG synthesis to mediate polycystic ovary syndrome. NgBR, neurite growth inhibitor-B receptor; SHBG, human sex hormone-binding globulin.

Research Article
Open access

A Shotgun Metagenomics Investigation into Labeling Inaccuracies in Widely Sold Probiotic Supplements in the USA

  •  10 June 2024

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The study analyzes 50 Over-the-Counter (OCT) probiotic supplements using shotgun metagenomics, finding 33% has labeling inaccuracies. Thirteen supplements have unlisted microorganisms, six lacks listed strains and three have both issues. Potential antimicrobial resistance genes are common, particularly in Bacillus-based supplements. Findings underscore the need for quality control and transparency to safeguard public health.

Research Article

Nobiletin Protects Against Alcoholic Liver Disease in Mice via the BMAL1‐AKT‐Lipogenesis Pathway

  •  8 June 2024

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Nobiletin mitigates ethanol-induced liver injury, apoptosis, and lipid accumulation in mice; however, these beneficial effects disappear when liver Bmal1 is depleted. Nobiletin reactivates ethanol-suppressed fatty acid β-oxidation through activating AKT, which improves the transcription of lipogenic genes. Activation of this pathway depends on Bmal1.

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Probiotics, gut microbiota, and their influence on host health and disease

  •  8 August 2016

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Probiotics exert health benefits on the host through interaction with specific components of the host (mostly epithelial and immune cells), notably at the mucosa level, involving different mechanisms of action and biological effects

Safety Aspects of the Use of Quercetin as a Dietary Supplement

  •  11 November 2017

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Identification of possible risk groups for the use of high quercetin doses in dietary supplement.

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