Pigment Cell & Melanoma Research is a dermatology journal publishing up-to-date manuscripts on all aspects of pigment cells and melanoma. From cell and molecular biology, development, genetics, to diseases of pigment cells, everything is comprehensively covered.

We look for papers that provide insights into the causes and progression of melanoma, aiming to advance the field and find ways to prevent this type of skin cancer, with a focus on the process of metastasis and invasion, proliferation, senescence, apoptosis or gene regulation. 

Skip slideshow

Articles

SPECIAL ARTICLE
Open access

Topical antibiotics limit depigmentation in a mouse model of vitiligo

  •  4 March 2024

Graphical Abstract

Description unavailable

Antibiotic ointments were topically applied to vitiligo-prone, pmel-1 mice, evaluating the consequences of short-term antibiotic treatment on the kinetics of depigmentation, microbial composition, infiltrating T-cell subsets, and inflammatory responses in the skin. Resulting findings can serve to guide the development of standalone or adjunct therapies to limit depigmentation in vitiligo patients.

SHORT COMMUNICATION

Genetic insights into Tietz albinism-deafness syndrome: A new dominant-negative mutation in MITF

  •  4 March 2024

Graphical Abstract

Description unavailable

We uncovered a previously unreported c.637G>C (p.Glu213Gln) mutation in the MITF in a patient with Tietz albinism-deafness syndrome (TADS), elucidating its genetic and clinical significance. The combined results from histopathological examination, transmission electron microscopy analysis, and melanin quantification underscored the substantial impairment caused by the p.Glu213Gln variant on melanosome maturation and melanin synthesis. Functional analysis demonstrated the dominant-negative effect of p.Glu213Gln along with other known mutations (p.Glu213Asp and p.Arg217del) within the basic domain of MITF, highlighting their collective impairment of DNA-binding ability. These findings significantly contribute to our comprehension of the fundamental pathogenic mechanisms involved in TADS.

REVIEW
free access

Emerging therapeutic strategies for metastatic uveal melanoma: Targeting driver mutations

  •  27 February 2024

Graphical Abstract

Description unavailable

In this review, we provide an overview of the emerging targeted and epigenetic therapeutic strategies for metastatic uveal melanoma harbouring specific driver mutations, which include GNAQ/11, BAP1 and SF3B1. Furthermore, we highlight the upcoming or ongoing clinical trials regarding these therapeutic strategies.

RESOURCE

The Yucatan miniature swine as a model for post‐inflammatory hyperpigmentation

  •  16 February 2024

Graphical Abstract

Description unavailable

Postinflammatory hyperpigmentation (PIH) is a common sequala following even minor injuries or irritation of the skin, especially in darker skin tones. Research and therapy development in PIH has been hampered by the lack of preclinical models. We have found that the Yucatan miniature pig consistently develops PIH after skin injuries (left). The lesions reproduce key characteristics of PIH in humans, including dermal melanin deposits (middle, arrows) that are associated not with melanocytes but with leukocytes (right, brown = melanin, red = CD45+ leukocytes).

REVIEW
Open access

Review: Are moles senescent?

  •  15 February 2024

Graphical Abstract

Description unavailable

Human melanocytic nevi (skin moles) are often regarded as being senescent lesions in vivo. This senescent state has been queried however based on findings including a quantitative study of induced mouse nevi, with potential diagnostic implications. Here, genetic, biological and molecular data on the issue are reviewed, yielding an updated model of the genetic changes in nevi as shown (TDIS: telomere dysfunction-induced senescence).

More articles

The following is a list of the most cited articles based on citations published in the last three years, according to CrossRef.

More articles

Latest news

Open Access

 

Submit your next research as an Open Access paper

Pigment Cell & Melanoma Research Online Open