Pigment Cell & Melanoma Research is a dermatology journal publishing up-to-date manuscripts on all aspects of pigment cells and melanoma. From cell and molecular biology, development, genetics, to diseases of pigment cells, everything is comprehensively covered.

We look for papers that provide insights into the causes and progression of melanoma, aiming to advance the field and find ways to prevent this type of skin cancer, with a focus on the process of metastasis and invasion, proliferation, senescence, apoptosis or gene regulation. 

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Articles

ORIGINAL ARTICLE

Risk factors for sentinel lymph node metastasis in Korean acral and non‐acral melanoma patients

  •  27 November 2023

Graphical Abstract

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Along with well known risk factors for sentinel lymph node (SLN) metastasis in cutaneous melanoma, heavy pigmentation might independently predict SLN positivity and be associated with poor recurrence-free survival.

ORIGINAL ARTICLE

MitoCur‐1 induces ferroptosis to reverse vemurafenib resistance in melanoma through inhibition of USP14

  •  20 November 2023

Graphical Abstract

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Graphic abstract illustrates that MitoCur-1 induces melanoma cell death and sensitization of vem-resistant melanoma cell through two ways: (1) inhibition of mitochondrial TrxR2, generation of ROS, and induction of the ROS-dependent glycolytic metabolisms (Zheng et al., Journal of Agricultural and Food Chemistry, 70, 2022, 2898–2910); (2) meanwhile, by inhibiting the expression of USP14, MitoCur-1 repressed activity of GPX4. The depletion of anti-oxidative enzyme aggravates the accumulation of lipid ROS and ferrous iron, and then triggers ferroptosis leading to melanoma cell death and overcoming vem resistance in melanoma.

SHORT COMMUNICATION
Open access

CD52 mRNA expression predicts prognosis and response to immune checkpoint blockade in melanoma

  •  17 November 2023

Graphical Abstract

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Expression of the immune-modulating gene CD52 correlates with differentiation, immune checkpoint expression, lymphocyte infiltration, and macrophage polarization and is associated with response to anti-PD-1 immunotherapy in melanoma.

ORIGINAL ARTICLE
Open access

Single-cell profiling of MC1R-inhibited melanocytes

  •  16 November 2023

Research Highlights

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Single-cell RNAseq of MC1R-inhibited melanocytes elucidates a set of differentially expressed genes with no previous ties to pigmentation or melanocyte biology. This list includes Tbx3 which we show binds to T- and E-boxes of candidate target genes, including those with known roles in pigmentation.

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