Pigment Cell & Melanoma Research is a dermatology journal publishing up-to-date manuscripts on all aspects of pigment cells and melanoma. From cell and molecular biology, development, genetics, to diseases of pigment cells, everything is comprehensively covered.

We look for papers that provide insights into the causes and progression of melanoma, aiming to advance the field and find ways to prevent this type of skin cancer, with a focus on the process of metastasis and invasion, proliferation, senescence, apoptosis or gene regulation.

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Articles

ORIGINAL ARTICLE

Age and urban–rural disparities in cutaneous melanoma mortality rates in the United States during the COVID-19 pandemic

  •  13 June 2024

Graphical Abstract

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In this serial population-based study, the National Vital Statistics System dataset was queried for mortality data. Excess CM-related mortality rates were estimated by calculating the difference between observed and projected mortality rates during the pandemic.

REVIEW
Open access

Journey through the spectacular landscape of melanocortin 1 receptor

  •  10 June 2024

Graphical Abstract

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Epidermal keratinocytes synthesize and secrete α-melanocyte stimulating hormone (α-MSH) and adrenocorticotropic hormone (ACTH). These act as agonists of the melanocortin 1 receptor expressed on the cell surface of human melanocytes. Binding of these physiological agonists or synthetic α-MSH analogs to human MC1R activates the cAMP pathway, leading to activation of transcription factors, mainly p53, MITF, and Nrf2. The downstream targets of these transcription factors enhance DNA repair and antioxidant capacities, promote melanocyte survival, and increase eumelanin synthesis. These pleotropic effects confer photoprotection and prevent vitiligo.

REVIEW
Open access

Xenopus as a model system for studying pigmentation and pigmentary disorders

  •  7 June 2024

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The amphibian Xenopus is a vertebrate animal model ideal for studying pigmentation changes in vivo due to its numerous advantages. These include shared evolutionary ancestry with mammals, high offspring production, cost-effective housing, the ability to perform live cell imaging, and well-developed genetic techniques, including gain- and loss-of-function tools for creating transgenic models. Additionally, Xenopus is valuable for investigating DNA repair efficiency and its impact on skin responses to ultraviolet radiation. Thus, Xenopus is a suitable model for studying melanocyte cell biology and related diseases.

ORIGINAL ARTICLE

Two-pore channel 2 is required for soluble adenylyl cyclase-dependent regulation of melanosomal pH and melanin synthesis

  •  6 June 2024

Graphical Abstract

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Model of mechanisms of cAMP-dependent regulation of pigmentation. Diagram depicts the distinct tmAC and sAC signaling cascades including all known downstream effector proteins and mechanisms that regulate pigmentation. Our data suggests that NAADP-induced, TPC2 activity is required for sAC-dependent regulation of melanosomal pH and pigmentation.

ORIGINAL ARTICLE

The effect of oxidative degradation of Dopa‐melanin on its basic physicochemical properties and photoreactivity

  •  27 May 2024

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Oxidative degradation of Dopa-melanin increases their photoreactivity and decrease the antioxidative potential.

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