As the official journal of Japanese Society for Neuroimmunology, Clinical and Experimental Neuroimmunology encourages authors from across the globe to exchange research on all areas of clinical and experimental neuroimmunology, covering neuroscience, basic immunology, clinical neurology, and neurovirology. Our focus is on research that optimize the treatment of neuroimmunological disorders such as multiple sclerosis and Guillain-Barré syndrome.

Articles

ORIGINAL ARTICLE
Open access

Real-world safety and treatment patterns of subcutaneous IgPro20 for chronic inflammatory demyelinating polyneuropathy: Post-marketing surveillance in Japan

Naoki Terasaka, Takanori Mizushima, Yuki Niwa, Tetsushi Akasaki, Hideo Usui, 
  •  3 October 2024
REVIEW ARTICLE
Open access

Human monocyte-derived microglia-like (iMG) cells: A tool to explore microglial dynamics

Sota Kyuragi, Shogo Inamine, Masahiro Ohgidani, Takahiro A. Kato, 
  •  29 September 2024
INVITED REVIEW

Common principles of macrophage biology in blood–tissue barriers

Shin-ichiro Hiraga, Takahiro Masuda, 
  •  23 September 2024
ORIGINAL ARTICLE
Open access

Safety and effectiveness of fingolimod in Japanese patients with multiple sclerosis: Results of a post-marketing surveillance study

Noriko Sato, Koji Wakimoto, Kyoko Kato, Yutaka Susuta, Kengo Ueda, Yoshihisa Satou, Takayoshi Sasajima, Jun-ichi Kira, 
  •  19 September 2024
ORIGINAL ARTICLE
Open access

Diagnostic testing and treatment in Japanese patients with a diagnosis code for chronic inflammatory demyelinating polyradiculoneuropathy: A claims database analysis

Motoi Kuwahara, Susumu Kusunoki, Ataru Igarashi, Satoshi Akiyama, Taku Fukushima, Mamoru Doi, 
  •  18 September 2024
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Articles with the most citations published in the Last 2 Years according to CrossRef. The citation counts listed reflect the total number of all citations to date.

Open access

The Japanese clinical guidelines 2022 for myasthenia gravis and Lambert–Eaton myasthenic syndrome

Hiroyuki Murai, Kimiaki Utsugisawa, Masakatsu Motomura, Tomihiro Imai, Akiyuki Uzawa, Shigeaki Suzuki, 

Role of sex hormones in neuroinflammation in Alzheimer's disease

Kasumi Maekawa, Koji Yamanaka, 

Eculizumab use throughout pregnancy in two patients with aquaporin‐4‐positive neuromyelitis optica spectrum disorder

Takeshi Fujimoto, Yasuhiro Maeda, 

Epidemiological study of myasthenia gravis in Japan

Hiroaki Yoshikawa, 
free access

The 34th Annual Meeting of the Japanese Society for Neuroimmunology (JSNI)

Multifactorial glial responses and their contributions to Alzheimer's disease continuum

Masanori Hijioka, Tatsuya Manabe, Takashi Saito, 

Neuroinflammation and neuroimmunology in Alzheimer's disease: The role of T-lymphocytes in Alzheimer's disease

Norio Chihara, Asato Tsuji, Riki Matsumoto, 
Open access

Bilateral longitudinally extensive optic perineuritis post-COVID-19 presenting as “idiopathic” intracranial hypertension: A case report

Mohammad Aladawi, Daniel Crespo, Renfeng Xu, Rana Zabad, Amrita-Amanda Vuppala, 

Autoimmune cerebellar ataxia

Hiroaki Yaguchi, Akihiko Kudo, Ichiro Yabe, 

Pathogenesis, clinical features and treatment of anti‐IgLON5 disease

Yoya Ono, Akio Kimura, Takayoshi Shimohata, 

Graphical Abstract

Pathogenesis, clinical features and treatment of anti-IgLON5 disease Issue 4, 2023

Anti-immunoglobulin-like cell adhesion molecule 5 (IgLON5) disease is an autoimmune encephalitis that presents with various symptoms, including sleep disorders, bulbar palsy, movement disorders, cognitive dysfunction and neuromuscular manifestations. Some patients have features mimicking neurodegenerative diseases, such as progressive supranuclear palsy and amyotrophic lateral sclerosis. In this review, we summarize the pathogenesis, clinical manifestations, diagnostic examination and treatment of anti-immunoglobulin-like cell adhesion molecule 5 disease.

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The most read articles published in the Last 2 Years

Open access

The Japanese clinical guidelines 2022 for myasthenia gravis and Lambert–Eaton myasthenic syndrome

Hiroyuki Murai, Kimiaki Utsugisawa, Masakatsu Motomura, Tomihiro Imai, Akiyuki Uzawa, Shigeaki Suzuki, 
Open access

Efficacy and safety of zilucoplan in Japanese patients with generalized myasthenia gravis: A subgroup analysis of the phase III randomized RAISE study

Kimiaki Utsugisawa, Kazushi Deguchi, Shingo Konno, Masayuki Masuda, Naoya Minami, Hiroyuki Murai, Shigeaki Suzuki, Yasushi Suzuki, Akira Tsujino, Akiyuki Uzawa, Babak Boroojerdi, Guillemette de la Borderie, Melissa Brock, Petra W. Duda, Mark Vanderkelen, James F. Howard, 
Open access

Myelin oligodendrocyte glycoprotein antibody‐associated disorders: An overview

Tatsuro Misu, Yuki Matsumoto, Kimihiko Kaneko, Toshiyuki Takahashi, Yoshiki Takai, Hirohiko Ono, Chihiro Namatame, Shuhei Nishiyama, Juichi Fujimori, Hiroshi Kuroda, Ichiro Nakashima, Kazuo Fujihara, Masashi Aoki, 
Open access

Expanding clinical spectrum from Hashimoto's encephalopathy to anti-NAE antibody-associated disorders (NAEAD)

Akiko Matsunaga, Masamichi Ikawa, Makoto Yoneda, 
Open access

Childhood myasthenia gravis in Japan: Pathophysiology and treatment options

Masatoshi Hayashi, 

Pathogenesis, clinical features and treatment of anti‐IgLON5 disease

Yoya Ono, Akio Kimura, Takayoshi Shimohata, 

Graphical Abstract

Pathogenesis, clinical features and treatment of anti-IgLON5 disease Issue 4, 2023

Anti-immunoglobulin-like cell adhesion molecule 5 (IgLON5) disease is an autoimmune encephalitis that presents with various symptoms, including sleep disorders, bulbar palsy, movement disorders, cognitive dysfunction and neuromuscular manifestations. Some patients have features mimicking neurodegenerative diseases, such as progressive supranuclear palsy and amyotrophic lateral sclerosis. In this review, we summarize the pathogenesis, clinical manifestations, diagnostic examination and treatment of anti-immunoglobulin-like cell adhesion molecule 5 disease.

Open access

Bilateral longitudinally extensive optic perineuritis post-COVID-19 presenting as “idiopathic” intracranial hypertension: A case report

Mohammad Aladawi, Daniel Crespo, Renfeng Xu, Rana Zabad, Amrita-Amanda Vuppala, 
Open access

Longitudinal imaging for monitoring disease activity in late-onset Rasmussen's encephalitis during multimodal rehabilitation and immune therapy

Lucas C. Adam, Lana Gilly, Joerg Mueller, Joerg Wissel, Anatol Kivi, 

Graphical Abstract

Longitudinal imaging for monitoring disease activity in late-onset Rasmussen's encephalitis during multimodal rehabilitation and immune therapy Issue ,

Multimodal immune therapy and supportive rehabilitation in late-onset Rasmussen's encephalitis patients result in clinical and imaging-based disease stabilization. Longitudinal magnetic resonance imaging is a feasible tool to monitor therapy response during immune therapy in late-onset Rasmussen's encephalitis patients.

free access

The 34th Annual Meeting of the Japanese Society for Neuroimmunology (JSNI)

Impact of early introduction of biologics on internal medications for neuromyelitis optica spectrum disorder

Kenzo Sakurai, Kenji Isahaya, Takeshi Imai, Yoshihisa Yamano, 
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