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Can single cell RNA sequencing reshape the clinical biochemistry of hematology: New clusters of circulating blood cells

Multiregion single-cell sequencing reveals the transcriptional landscape of the immune microenvironment of colorectal cancer

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Altered lipidomic profiles in patients with and without osteonecrosis of the femoral head after 1-month glucocorticoid treatment

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Clinical and Translational Medicine open access

Articles

RESEARCH ARTICLE
Open access

Elucidating epigenetic landscape of gastric premalignant lesions through genome‐wide mapping of 5‐hydroxymethylcytosines: A 12‐year median follow‐up study

Zhongguang Luo, Wenshuai Li, Wanwei Zheng, Yixiang Shi, Maolin Ye, Xiangyu Guo, Kaiyi Fu, Changsheng Yan, Bowen Wang, Bin Lv, Shaocong Mo, Hongyang Zhang, Jun Zhang, Chuan He, Feifei Luo, Wei Zhang, Jie Liu, 
  •  3 December 2024

Graphical Abstract

Elucidating epigenetic landscape of gastric premalignant lesions through genome-wide mapping of 5-hydroxymethylcytosines: A 12-year median follow-up study Issue 12, 2024

  • A largest longitudinal follow-up study of gastric precursor lesions in Chinese patients.
  • Revealing novel 5hmC molecular landscape linked to gastric premalignant lesions.
  • The feasibility of an innovative 5hmC-based predictive model for assessing gastric cancer progression risk.

RESEARCH ARTICLE
Open access

Glucose‐induced LINC01419 reprograms the glycolytic pathway by recruiting YBX1 to enhance PDK1 mRNA stability in hepatocellular carcinoma

Yanfang Liu, Junjiao Song, Qili Shi, Bing Chen, Wenying Qiu, Yizhe Liu, Shenglin Huang, Xianghuo He, 
  •  3 December 2024

Graphical Abstract

Glucose-induced LINC01419 reprograms the glycolytic pathway by recruiting YBX1 to enhance PDK1 mRNA stability in hepatocellular carcinoma Issue 12, 2024

  • This study highlights the considerable regulatory role of LINC01419 in the metabolism of HCC.
  • The newly identified LINC01419/YBX1-PDK1 axis constitutes a valuable target.
  • Hepatic-specific delivery of GalNAc-siLINC01419 presents a promising therapeutic strategy for HCC.
.

RESEARCH ARTICLE
Open access

Extracellular vesicles derived from creeping fat stem cells promote lymphatic function and restrain inflammation of Crohn's disease

Weigang Shu, Yongheng Wang, Mengfan Chen, Xiaoli Zhu, Fangtao Wang, Chunqiu Chen, Peng Du, Alexandra Bartolomucci, Xin Su, Xiaolei Wang, 
  •  2 December 2024

Graphical Abstract

Extracellular vesicles derived from creeping fat stem cells promote lymphatic function and restrain inflammation of Crohn's disease Issue 12, 2024

1. Extracellular vesicles (EVs) derived from adipose tissue-derived stem cells in creeping fat (CrF) improve lymphatic functions and increase mesenteric lymphatic vessel density of Il-10-/– mice, leading to decreased colitis and mesenteritis through the miR-132-3p/RASA1 /ERK1/2 axis.

2. Co-culturing human lymphatic endothelial cells with CrF-EVs promotes proliferation, migration and tube function in vitro.

3. Upregulated miR-132-3p in CrF was negatively correlated with proinflammatory cytokines. Moreover, serum miR-132-3p was positively correlated with disease activity.

REVIEW
Open access

The role of the interplay between macrophage glycolytic reprogramming and NLRP3 inflammasome activation in acute lung injury/acute respiratory distress syndrome

Lan Luo, Xiaoli Zhuang, Lin Fu, Ziyuan Dong, Shuyuan Yi, Kan Wang, Yu Jiang, Ju Zhao, Xiaofang Yang, Feilong Hei, 
  •  2 December 2024

Graphical Abstract

The role of the interplay between macrophage glycolytic reprogramming and NLRP3 inflammasome activation in acute lung injury/acute respiratory distress syndrome Issue 12, 2024

  • NLRP3 inflammasome activation is pivotal in mediating the excessive inflammatory response in ALI/ARDS.
  • Glycolytic reprogramming regulates NLRP3 inflammasome activation.
  • Therapeutic potential of targeting glycolytic reprogramming to inhibit NLRP3 inflammasome activation in ALI/ARDS.

LETTER TO THE JOURNAL
Open access

Integration of single‐cell and bulk RNA sequencing unravels metalloendopeptidase+ neutrophils as key inflammatory drivers in abdominal aortic aneurysm

Lushun Yuan, Chuan Liang, Shuzhen Cheng, Jianliang Zhou, Song Chen, 
  •  2 December 2024
COMMENTARY
Open access

Importance of integrating epidemiological and genomic surveillance of seasonal influenza viruses to monitor global circulation

Zhiyuan Chen, Hongjie Yu, 
  •  2 December 2024
COMMENTARY
Open access

Are we any closer to optimising amblyopia treatment?

Frank Antony Proudlock, Irene Gottlob, 
  •  1 December 2024
LETTER TO THE JOURNAL
Open access

Spatial transcriptomics deciphers the immunosuppressive microenvironment in colorectal cancer with tumour thrombus

Heming Ge, Zhengda Pei, Zhongyi Zhou, Qian Pei, Cenap Güngör, Linyi Zheng, Wei Liu, Fengyuan Li, Jingxuan Zhou, Yao Xiang, Haiping Pei, Yuqiang Li, Wenxue Liu, 
  •  1 December 2024
COMMENTARY
Open access

A symbiotic mosquito‐gut bacterium for flavivirus control

Jinglin Wang, Yibin Zhu, Jun Leng, Yulin Yuan, Yingyi Cao, Gong Cheng, Xueshan Xia, 
  •  29 November 2024

Graphical Abstract

A symbiotic mosquito-gut bacterium for flavivirus control Issue 12, 2024

RESEARCH ARTICLE
Open access

The gut microbiota‐derived metabolite indole‐3‐propionic acid enhances leptin sensitivity by targeting STAT3 against diet‐induced obesity

Zhiwei Wang, Shaying Yang, Liangju Liu, Aiqin Mao, Hao Kan, Fan Yu, Xin Ma, Lei Feng, Tingting Zhou, 
  •  28 November 2024

Graphical Abstract

The gut microbiota-derived metabolite indole-3-propionic acid enhances leptin sensitivity by targeting STAT3 against diet-induced obesity Issue 12, 2024

  • IPA-based gut-brain axis regulates host metabolism.

  • IPA is a leptin sensitiser.

  • STAT3 protein is the target of IPA.

  • The circulating levels of IPA are affected by a high-fat diet.

More articles

Articles with the most citations published in the Last 2 Years according to CrossRef. The citation counts listed reflect the total number of all citations to date.

REVIEW
Open access

Neutrophil, neutrophil extracellular traps and endothelial cell dysfunction in sepsis

Hao Zhang, Yanghanzhao Wang, Mengdi Qu, Wenqian Li, Dan Wu, Juan P. Cata, Changhong Miao, 

Graphical Abstract

Neutrophil, neutrophil extracellular traps and endothelial cell dysfunction in sepsis Issue 1, 2023

1. Neutrophils show increased lifespan and impaired migration, both of which promote organ damage.

2. Neutrophils and neutrophil extracellular traps (NETs) induce pro-inflammatory and pro-angiogenic responses in endothelial cells.

3. Neutrophils and NETs degrade glycocalyx and increase endothelial permeability.

4. Neutrophils and NETs induce a pro-coagulant endothelial cell phenotype via degradation of the anti-coagulation system and up-regulation of tissue factors.

RESEARCH ARTICLE
Open access

Multiplex immunofluorescence and single‐cell transcriptomic profiling reveal the spatial cell interaction networks in the non‐small cell lung cancer microenvironment

Haoxin Peng, Xiangrong Wu, Shaopeng Liu, Miao He, Chao Xie, Ran Zhong, Jun Liu, Chenshuo Tang, Caichen Li, Shan Xiong, Hongbo Zheng, Jianxing He, Xu Lu, Wenhua Liang, 

Graphical Abstract

Multiplex immunofluorescence and single-cell transcriptomic profiling reveal the spatial cell interaction networks in the non-small cell lung cancer microenvironment Issue 1, 2023

  • Deep learning algorithm on multiplex immunofluorescence images identified cell spatial patterns with prognostic effects in the lung cancer microenvironment.
  • Single-cell RNA-sequencing revealed the cell interaction networks suggested by spatial paradigm analyses.
  • Proximity among CD4+ T cells, CD20+ B cells and N1-like neutrophils, and spatial compartmentalisation between cancer stem cells and CD8+ T cells, were associated with significantly longer disease-free survival.

RESEARCH ARTICLE
Open access

Exosome‐derived circTFDP2 promotes prostate cancer progression by preventing PARP1 from caspase‐3‐dependent cleavage

Lifeng Ding, Qiming Zheng, Yudong Lin, Ruyue Wang, Huan Wang, Wenqin Luo, Zeyi Lu, Haiyun Xie, Liangliang Ren, Haohua Lu, Chenhao Yu, Jixuan Zhang, Danyang Shen, Sheng Cheng, Liqun Xia, Gonghui Li, Dingwei Xue, 

Graphical Abstract

Exosome-derived circTFDP2 promotes prostate cancer progression by preventing PARP1 from caspase-3-dependent cleavage Issue 1, 2023

1. circTFDP2 is upregulated in prostate cancer tissues and positively correlated with the Gleason score, metastasis status and T stage of prostate cancer patients.

2. circTFDP2 promotes prostate cancer progression via directly binding to PARP1.

3. circTFDP2 could be secreted to the cell culture by exosomes.

COMMENTARY
Open access

The potential impact of ChatGPT in clinical and translational medicine

Vivian Weiwen Xue, Pinggui Lei, William C. Cho, 
REVIEW
Open access

Keeping an eye on circadian time in clinical research and medicine

Elizabeth B. Klerman, Allison Brager, Mary A. Carskadon, Christopher M. Depner, Russell Foster, Namni Goel, Mary Harrington, Paul M. Holloway, Melissa P. Knauert, Monique K. LeBourgeois, Jonathan Lipton, Martha Merrow, Sara Montagnese, Mingming Ning, David Ray, Frank A. J. L. Scheer, Steven A. Shea, Debra J. Skene, Claudia Spies, Bart Staels, Marie-Pierre St-Onge, Steffen Tiedt, Phyllis C. Zee, Helen J. Burgess, 

Graphical Abstract

Keeping an eye on circadian time in clinical research and medicine Issue 12, 2022

Understanding the contribution of the endogenous circadian system to observed time-of-day rhythms can yield insights that further health-related research and optimize clinical treatments and increase life expectancy. This manuscript provides guidance on best practices in measuring and distinguishing endogenous circadian rhythms from time-of-day rhythms in a variety of settings.

RESEARCH ARTICLE
Open access

Dissecting the role of cancer‐associated fibroblast‐derived biglycan as a potential therapeutic target in immunotherapy resistance: A tumor bulk and single‐cell transcriptomic study

Shaoquan Zheng, Jie-Ying Liang, Yuhui Tang, Jindong Xie, Yutian Zou, Anli Yang, Nan Shao, Xiaying Kuang, Fei Ji, Xuefeng Liu, Wenwen Tian, Weikai Xiao, Ying Lin, 

Graphical Abstract

Dissecting the role of cancer-associated fibroblast-derived biglycan as a potential therapeutic target in immunotherapy resistance: A tumor bulk and single-cell transcriptomic study Issue 2, 2023

  • There are tight correlations between CAFs and immune cells in pan-cancer bulk cohort.
  • Single-cell data reveals regulators for CAFs and frequent crosstalk with other cells.
  • In various cancers, stromal biglycan is dominantly derived from CAFs.
  • Biglycan is an unfavourable indicator for survival and immunotherapy response in cancer.

COMMENTARY
Open access

The opportunities and pitfalls of ChatGPT in clinical and translational medicine

Christian Baumgartner, 
LETTER TO THE JOURNAL
Open access

Deciphering the suppressive immune microenvironment of prostate cancer based on CD4+ regulatory T cells: Implications for prognosis and therapy prediction

Qintao Ge, Zhijie Zhao, Xiao Li, Feixiang Yang, Meng Zhang, Zongyao Hao, Chaozhao Liang, Jialin Meng, 
REVIEW
Open access

Geranylgeranyl diphosphate synthase: Role in human health, disease and potential therapeutic target

Molly E. Muehlebach, Sarah A. Holstein, 

Graphical Abstract

Geranylgeranyl diphosphate synthase: Role in human health, disease and potential therapeutic target Issue 1, 2023

  • Geranylgeranyl diphosphate synthase (GGDPS), an enzyme in the isoprenoid biosynthesis pathway, is responsible for the production of geranylgeranyl pyrophosphate (GGPP) used for protein geranylgeranylation.
  • Dysregulation of GGDPS expression and/or activity is implicated in the pathophysiology of type 2 diabetes, liver disease, pulmonary disease and several malignancies.
  • GGDPS inhibitors have promising efficacy in preclinical models of malignancy and pulmonary fibrosis.

EDITORIAL
Open access

Initiative of clinical single‐cell biomedicine in clinical and translational medicine

Fangming Liu, Xuanqi Liu, Charles A Powell, Chengshui Chen, Yiming Zeng, Hao Fang, Xiangdong Wang, 
More articles

The most read articles published in the Last 2 Years

Open access

Neutrophil, neutrophil extracellular traps and endothelial cell dysfunction in sepsis

Hao Zhang, Yanghanzhao Wang, Mengdi Qu, Wenqian Li, Dan Wu, Juan P. Cata, Changhong Miao, 
Open access

Single-cell and spatial transcriptomics reveal POSTN+ cancer-associated fibroblasts correlated with immune suppression and tumour progression in non-small cell lung cancer

Chao Chen, Qiang Guo, Yang Liu, Qinghua Hou, Mengying Liao, Yanying Guo, Yupeng Zang, Fei Wang, Huanyu Liu, Xinyu Luan, Yanling Liang, Zhuojue Guan, Yanling Li, Haozhen Liu, Xuan Dong, Xiuqing Zhang, Jixian Liu, Qumiao Xu, 
Open access

mRNA vaccine in cancer therapy: Current advance and future outlook

Youhuai Li, Mina Wang, Xueqiang Peng, Yingying Yang, Qishuang Chen, Jiaxing Liu, Qing She, Jichao Tan, Chuyuan Lou, Zehuan Liao, Xuexin Li, 
Open access

The molecular classification of cancer‐associated fibroblasts on a pan‐cancer single‐cell transcriptional atlas

Bonan Chen, Wai Nok Chan, Fuda Xie, Chun Wai Mui, Xiaoli Liu, Alvin H. K. Cheung, Raymond W. M. Lung, Chit Chow, Zhenhua Zhang, Canbin Fang, Peiyao Yu, Shihua Shi, Shikun Zhou, Guoming Chen, Zhangding Wang, Shouyu Wang, Xiaofan Ding, Bing Huang, Li Liang, Yujuan Dong, Chi Chun Wong, William K. K. Wu, Alfred S. L. Cheng, Nathalie Wong, Jun Yu, Kwok Wai Lo, Gary M. K. Tse, Wei Kang, Ka Fai To, 
Open access

METTL3‐mediated N6‐methyladenosine exacerbates ferroptosis via m6A‐IGF2BP2‐dependent mitochondrial metabolic reprogramming in sepsis‐induced acute lung injury

Hao Zhang, Dan Wu, Yanghanzhao Wang, Kefang Guo, Charles B. Spencer, Lilibeth Ortoga, Mengdi Qu, Yuxin Shi, Yuwen Shao, Zhiping Wang, Juan P. Cata, Changhong Miao, 
Open access

Multiplex immunofluorescence and single‐cell transcriptomic profiling reveal the spatial cell interaction networks in the non‐small cell lung cancer microenvironment

Haoxin Peng, Xiangrong Wu, Shaopeng Liu, Miao He, Chao Xie, Ran Zhong, Jun Liu, Chenshuo Tang, Caichen Li, Shan Xiong, Hongbo Zheng, Jianxing He, Xu Lu, Wenhua Liang, 
Open access

Single‐cell transcriptome sequencing of B‐cell heterogeneity and tertiary lymphoid structure predicts breast cancer prognosis and neoadjuvant therapy efficacy

Qing Wang, Ke Sun, Rui Liu, Ying Song, Yafeng Lv, Pingping Bi, Fuying Yang, Sijia Li, Jiawen Zhao, Xiuqin Li, Dong Chen, Jialin Mei, Rirong Yang, Kai Chen, Dequan Liu, Shicong Tang, 
Open access

H. pylori-induced NF-κB-PIEZO1-YAP1-CTGF axis drives gastric cancer progression and cancer-associated fibroblast-mediated tumour microenvironment remodelling

Bonan Chen, Xiaoli Liu, Peiyao Yu, Fuda Xie, Johnny S. H. Kwan, Wai Nok Chan, Canbin Fang, Jinglin Zhang, Alvin H. K. Cheung, Chit Chow, Gloria W. M. Leung, Kam Tong Leung, Shihua Shi, Bin Zhang, Shouyu Wang, Dazhi Xu, Kaili Fu, Chi Chun Wong, William K. K. Wu, Michael W. Y. Chan, Patrick M. K. Tang, Chi Man Tsang, Kwok Wai Lo, Gary M. K. Tse, Jun Yu, Ka Fai To, Wei Kang, 
Open access

Spatiotemporally deciphering the mysterious mechanism of persistent HPV‐induced malignant transition and immune remodelling from HPV‐infected normal cervix, precancer to cervical cancer: Integrating single‐cell RNA‐sequencing and spatial transcriptome

Chenyan Guo, Xinyu Qu, Xiaoyan Tang, Yu Song, Jue Wang, Keqin Hua, Junjun Qiu, 
Open access

Integrated single‐cell and spatial transcriptomic profiling reveals higher intratumour heterogeneity and epithelial–fibroblast interactions in recurrent bladder cancer

Zhen-Duo Shi, Zhuo Sun, Zuo-Bin Zhu, Xing Liu, Jun-Zhi Chen, Lin Hao, Jie-Fei Zhu, Kun Pang, Di Wu, Yang Dong, Yu-Fei Liu, Wei-Hua Chen, Qing Liang, Shi-Chao Zhuo, Cong-Hui Han, 
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