As the official journal of the Asian Association for the Study of Diabetes (AASD), Journal of Diabetes Investigation is a clinical and experimental diabetes research journal encompassing basic science, clinical practice, and epidemiology in diabetes. Our scope also covers related areas including prevention and treatment, as well as molecular aspects and pathophysiology.

We publish translational research, providing a forum for clinicians and researchers to exchange ideas.

Articles

“JDI Updates” are at-a-glance articles to stay up-to-date on hot topics in diabetes.


Please read the virtual issue on Insulin Secretion/β-cell

Open access

Coexistence of type 2 diabetes mellitus, arginine vasopressin deficiency, and Marfan syndrome: A case report

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For those patients with type 2 diabetes mellitus, the existence of arginine vasopressin deficiency should be considered when polyuria is not in accordance with the blood glucose levels, especially for those with a low urine specific gravity. Specific symptoms or signs help to identify Marfan syndrome early, and genetic testing of the FBN1 pathogenetic variant helps to make a definitive diagnosis.

Open access

Modification effect of receipt of diabetes care on the association between COVID-19 infection and HbA1c level during the first year of the coronavirus pandemic using a nationwide population-based database

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Untreated diabetes was reportedly a risk factor for severe COVID-19 disease, but its association with an increased risk of COVID-19 infection is unclear. Individuals without diabetes care in 2019 had a risk of COVID-19 infection in 2020 that was proportional to their HbA1c levels, whereas those receiving diabetes care had a similar risk across various HbA1c levels. This population-based study revealed that adherence to diabetes care may have reduced COVID-19 infection risk in Japan among individuals with diabetes and HbA1c levels ≥8%.

Open access

Diabetes treatment by conversion of gut epithelial cells to insulin‐producing cells

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Converting gut cells into insulin-producing cells has emerged as an attractive therapeutic option to treat diabetes. Here, we summarize this field and review its clinical potential.

Open access

An exploratory study of factors in disordered eating behavior in diabetes self‐management in Japan

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Negative mood especially anger and hostility is an important factor in appetite control and increased cortisol secretion, and can be an impediment to successful dietary self-management in patients with type 2 diabetes.

Open access

Interaction effect between low birthweight and resistin gene rs1862513 variant on insulin resistance and type 2 diabetes mellitus in adulthood: Toon Genome Study

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Interaction between low birthweight influenced by intrauterine environment and resistin gene rs1862513 variant is potentially associated with insulin resistance and type 2 diabetes mellitus in adulthood.

Open access

Simplified electrophysiological approach combining a point‐of‐care nerve conduction device and an electrocardiogram produces an accurate diagnosis of diabetic polyneuropathy

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The gold standard electromyography system diagnosis of diabetic polyneuropathy can be replicated using two simple quantitative tests: DPNCheck™ and coefficient of variation of R-R intervals. By combining these tests, we have developed an estimation formula with excellent diagnostic performance. The use of DPNCheck and electrocardiogram would simplify the diagnosis of diabetic polyneuropathy, making it more accessible, reproducible and reliable.

Open access

High‐density lipoprotein in diabetes: Structural and functional relevance

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HDL particles are highly heterogeneous, and there are quantitative and qualitative changes as well as functional abnormalities of HDL particles in both type 1 and type 2 diabetes. HDL dysfunction is common in diabetes and contributes to the increased cardiovascular risk in people with diabetes.

Open access

Association between serum uric acid‐to‐high‐density lipoprotein cholesterol ratio and insulin resistance in an American population: A population‐based analysis

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Elevated UHR demonstrates a significant association with insulin resistance within the American population. UHR is more effective in detecting IR compared with the use of HDL-C or UA alone. A non-linear association between IR risk and UHR was discovered.

Open access

Maternal birth weight as an indicator of early and late gestational diabetes mellitus: The Japan Environment and Children's Study

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This is the first study to investigate the association between maternal birth weight (MBW) and gestational diabetes mellitus (GDM) according to gestational age when gestational diabetes mellitus was diagnosed. Lower maternal birth weight was associated with an increased risk of developing both early and late gestational diabetes mellitus.

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Welcome to Journal of Diabetes Investigation Special Issue page

All articles published in the journal is open access - immediately free to read, download and share.

Special Issue: Diabetes and Big Data
January 2024

Issue Edited by:
Weiping Jia


Open access

Glycemic variability: Measurement, target, impact on complications of diabetes and does it really matter?

Abstract

The role of glycemic variability (GV) in the development of diabetes complications remains uncertain. In this literature review, we aimed to summarize the existing evidence regarding the measurement, target level, pathophysiological mechanisms relating GV and tissue damage, and population-based studies of GV and diabetes complications. Additionally, we introduce novel methods for measuring GV, and discuss several unresolved issues of GV.

Open access

The role of lipid dysregulation in gestational diabetes mellitus: Early prediction and postpartum prognosis

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Lipid dysregulation exhibits a robust association with gestational diabetes (GDM), and the identification of lipid biomarkers has enabled their application in the early prediction of both GDM and the subsequent onset of type 2 diabetes following delivery.

Open access

Decline in measured glomerular filtration rate is associated with simple renal cyst in Chinese patients with type 2 diabetes

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This study aimed to investigate the relationship between simple renal cysts (SRC) and measured GFR (mGFR) in 3,552 diabetes patients in China. The isotope dynamic renal scintigraphy, which is able to reflect the function of both kidneys separately, was used for GFR measurement in this cross-sectional study. Participants with SRC had significantly lower mGFR values than those without SRC, and the prevalence of SRC gradually increased with decreasing mGFR level (Figure 2a). In 478 participants with unilateral renal cyst, the mGFR of the kidney affected by SRC was significantly lower than that of the unaffected kidney (Figure 3b).

Open access

Association of RPS26 gene polymorphism with different types of diabetes in Chinese individuals

Abstract

In this manuscript, we explored whether RPS26 gene polymorphisms conferred susceptibility to type 1 diabetes mellitus, latent autoimmune diabetes in adults and type 2 diabetes mellitus in a considerably large collection of Chinese participants. The effects of this gene on clinical features of patients, including age at diagnosis, β-cell function, and islet autoantibodies were also comprehensively investigated. We have found that the SNP, rs1131017, of the RPS26 gene is a genetic susceptibility locus for type 1 diabetes mellitus and latent autoimmune diabetes in adults in the Chinese Han population, but it has no impact on susceptibility to type 2 diabetes mellitus. Our research provides evidence for the important role of RPS26 in the genetic susceptibility of type 1 diabetes mellitus, offering a new biomarker for risk assessment and precise diagnosis of diabetes.

Open access

Association of serum amyloid A and prognosis in people with diabetes and COVID-19: A retrospective cohort study

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We aimed to analyze the association between SAA and the prognosis of patients with COVID-19 and diabetes. SAA levels are strongly associated with poor prognosis in COVID-19 and diabetes patients.

Open access

Identification of eight genomic protective alleles for mitochondrial diabetes by Kinship‐graph convolutional network

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We analyzed a whole genome sequencing dataset from blood samples of 38 maternally inherited diabetes and deafness patients with m.3243A > G belonging to 10 pedigrees, by developing a Kinship-graph convolutional network approach integrated with conventional GWAS methods. In this way, we identified eight nuclear genome alleles, which showed three protective effects involved in the onset of MIDD, related deafness, and prevention of type 2 diabetes.

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